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Nano biological active glass material and preparation method thereof

A kind of bioactive glass and nanotechnology, applied in medical science, prosthesis, etc., can solve the problems of poor dispersion, uneven size, and uncontrollable shape of bioactive glass particles, so as to support bone cell growth, inhibit agglomeration, and promote bone cell growth. The effect of calcium deposition

Inactive Publication Date: 2017-10-20
常州杰轩纺织科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main technical problem to be solved by the present invention is to provide a nano-bioactive glass material and its preparation method in view of the defects of poor particle dispersion, uneven size and uncontrollable shape in the bioactive glass prepared by the existing sol-gel method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Take 0.6mol tetraethyl orthosilicate, add 2.4L mass fraction of 25% ethanol solution, stir at 300r / min for 10min, and adjust the pH to 0.8 with nitric acid, then add 0.08mol triethyl phosphate, 0.01mol zinc nitrate, 60g Chitosan, continue to stir for 20min to obtain a sol, take 0.16mol of calcium nitrate, add it to 1.8L deionized water, stir at 300r / min for 20min, then add 240g of polyvinyl alcohol P6000, continue to stir for 20min to obtain a dispersion, and dissolve the sol The solution was dropped into the dispersion liquid at 5mL / min, and continuously stirred at 300r / min until the dropwise addition was completed, then ammonia water was added to adjust the pH to 12.0, and after standing for 1h, the precipitate was separated by centrifugation, and the precipitate was placed in a vacuum freeze-drying box. Dry at -30°C for 20 hours to obtain freeze-dried powder, place the freeze-dried powder in a muffle furnace, heat to 600°C at 1°C / min, calcinate for 4 hours, and discha...

example 2

[0026] Take 0.7mol ethyl orthosilicate, add 3.0L mass fraction of 25% ethanol solution, stir at 350r / min for 15min, and adjust the pH to 0.9 with nitric acid, then add 0.09mol triethyl phosphate, 0.01mol zinc nitrate, 75g Gelatin, continue to stir for 25min to obtain a sol, take 0.26mol calcium nitrate, add it to 2.1L deionized water, stir at 350r / min for 25min, then add 300g of polyvinyl alcohol P10000, and continue to stir for 25min to obtain a dispersion, mix the sol with Drop into the dispersion liquid at 8mL / min, and continue to stir at 350r / min until the dropwise addition is complete, then add ammonia water to adjust the pH to 12.3, and after standing for 1h, centrifuge to obtain a precipitate, put the precipitate in a vacuum freeze-drying box, and put it in a - Dry at 25°C for 22 hours to obtain freeze-dried powder. Place the freeze-dried powder in a muffle furnace, heat to 625°C at 3°C / min, calcinate for 5 hours, and discharge after cooling to room temperature to obtain...

example 3

[0028] Take 0.8mol ethyl orthosilicate, add 3.6L mass fraction of 25% ethanol solution, stir at 400r / min for 20min, and adjust the pH to 1.0 with nitric acid, then add 0.10mol triethyl phosphate, 0.02mol zinc nitrate, 90g Glucose, continue to stir for 30min to obtain a sol, take 0.36mol of calcium nitrate, add it to 2.4L of deionized water, stir at 400r / min for 30min, then add 360g of polyvinyl alcohol P20000, and continue to stir for 30min to obtain a dispersion. Drop into the dispersion liquid at 10mL / min, and continue to stir at 400r / min until the dropwise addition is complete, then add ammonia water to adjust the pH to 12.5, and after standing for 2 hours, centrifuge to obtain a precipitate, put the precipitate in a vacuum freeze-drying box, and place it in the - Dry at 20°C for 24 hours to obtain freeze-dried powder. Place the freeze-dried powder in a muffle furnace, heat to 650°C at 5°C / min, calcinate for 6 hours, and discharge after cooling to room temperature to obtain ...

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Abstract

The invention discloses a nano biological active glass material and a preparation method thereof, which belongs to the technical field of preparation of medical materials. The preparation method comprises the following steps: dissolving tetraethoxysilane in an ethanol solution, adjusting the pH by using nitric acid, adding triethyl phosphate, zinc nitrate and a template agent, mixing to obtain a sol solution, mixing calcium nitrate and deionized water, adding a dispersing agent, obtaining a dispersion, mixing the sol solution and the dispersion, adjusting the pH by using ammonia water, standing, centrifuging to obtain precipitates, finally freeze drying the precipitates, calcining, cooling, and discharging the material, thus obtaining the nano biological active glass material. The biological active glass prepared by the invention has the characteristics of uniform particle size, good dispersity, high porosity and large specific area, can effectively improve the biological activity of the material, has relatively good drug loading capacity and is an ideal medical material.

Description

technical field [0001] The invention discloses a nano bioactive glass material and a preparation method thereof, belonging to the technical field of medical material preparation. Background technique [0002] Bioactive glass is one of the hot spots in the research of bone tissue repair materials at present, and it has good bioactivity and biocompatibility. It is mainly composed of SiO 2 、Na 2 O, CaO and P 2 o 5 Composition, after implanted in the human body, through the circulation of body fluids, ion exchange between the bioactive glass and soft tissue and bone can occur, so that a chemical bond is formed between the material interface and human bone tissue. This ion exchange plays a role in mineralization, and finally Forms a layer of hydroxyapatite that mimics the mineral form of normal bone tissue, thereby inducing more rapid bone repair and regeneration. Therefore, bioactive glass has a good prospect for clinical application. [0003] Currently, bioactive glasses ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/10A61L27/56A61L27/50C03C12/00
Inventor 王海霞王之霖潘宏梅
Owner 常州杰轩纺织科技有限公司
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