Synthetic method for xylonic acid

A synthesis method and technology of xylonic acid, applied in chemical instruments and methods, separation/purification of carboxylic acid compounds, preparation of carboxylate salts, etc., can solve problems such as large environmental pollution, harsh culture conditions, harsh reaction conditions, etc. Improve product quality, reduce production costs, and respond quickly

Inactive Publication Date: 2017-11-10
JINAN SHENGQUAN GROUP SHARE HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The literature of The Development of Cement and Concrete Additive focuses on the palladium oxidation method and microbial oxidation method. Due to the high price of heavy metals, high environmental pollution, harsh reaction conditions, long culture period and harsh culture conditions of natural strains, their large-scale commercialization is limited. application
[0005] The application number is 201210191920.7 which discloses a method for producing xylose acid (salt) by whole-cell efficient catalysis of xylose conversion, and the application number is 201210539717.4 which discloses a method for biologically synthesizing xylose acid. The key points of these two patent documents are It describes the construction of engineering bacteria by genetic engineering methods to biosynthesize xylonic acid. Due to some uncertainties in molecular experiments and high costs, it cannot be produced on a large scale

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A synthetic method for xylonic acid, comprising the following steps:

[0037] Add 30.51g of D-xylose to a 250ml four-neck flask, and dilute to 150g with water;

[0038] After mixing, add 45.76 g of activated carbon, feed oxygen under stirring, control the temperature of the oil bath at 48-50°C, and adjust the pH of the solution to 9.5-9.8 with a sodium hydroxide solution with a mass concentration of 25%.

[0039] After reacting for 6 hours, filter the activated carbon, and measure the xylose content in the obtained liquid by high performance liquid chromatography, the xylose content in the solution is 3.8%, and the calculated xylose conversion rate is 81.32%;

[0040] The sodium xylose solution obtained by filtering is passed through 732 cation exchange resins to obtain a xylose acid solution;

[0041] A chromatographic column AIltech C18 was used to detect the xylonic acid solution, and the peak appeared at about 10 minutes. Compared with the standard product, the con...

Embodiment 2

[0043] A synthetic method for xylonic acid, comprising the following steps:

[0044] Add 30.30g of D-xylose to a 250ml four-neck flask, and dilute to 150g with water;

[0045] After mixing, add 30.30 g of granular activated carbon, introduce oxygen under stirring, control the temperature of the oil bath at 45-48 ° C, and adjust the pH of the solution to 9.5-9.8 with a sodium hydroxide solution with a mass concentration of 25%;

[0046] After reacting for 6 hours, the activated carbon was filtered, and the xylose content in the obtained liquid was measured by high performance liquid chromatography. The xylose content in the solution was measured to be 5.8%, and the xylose conversion rate was calculated to be 71.29%;

[0047] The sodium xylose solution obtained by filtering is passed through 732 cation exchange resins to obtain a xylose acid solution;

[0048] Detected by chromatographic column Altech C18, the peak appeared at about 10min, compared with the standard, the conten...

Embodiment 3

[0050] A synthetic method for xylonic acid, comprising the following steps:

[0051] Add 46.05g of D-xylose to a 250ml four-neck flask, and dilute to 150g with water;

[0052] After mixing, add 69.08g of granular activated carbon, feed oxygen under stirring, control the temperature of the oil bath at 48-50°C, and adjust the pH to 9.2-9.5 with a sodium hydroxide solution with a mass concentration of 25%.

[0053] After reacting for 6 hours, the activated carbon was filtered, and the xylose content in the obtained liquid was measured by high performance liquid chromatography. The xylose content in the solution was measured to be 4.3%, and the calculated xylose conversion rate was 85.99%;

[0054] The sodium xylose solution obtained by filtering is passed through 732 cation exchange resins to obtain a xylose acid solution;

[0055]Detected with chromatographic column AIltech C18, the peak appeared at about 10min, compared with the standard product, the content of xylonic acid wa...

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Abstract

The invention relates to the field of xylonic acid production, and especially relates to a synthetic method for xylonic acid. The xylonic acid is obtained by using a d-xylose solution as a reaction liquid and activated carbon as a catalyst, introducing oxygen, adjusting the pH of the reaction liquid to 8-10, performing reaction, and performing separation and purification after the reaction is finished. According to the synthetic method for the xylonic acid provided in the invention, xylose is taken as a raw material, the activated carbon is taken as the catalyst, when the pH is 8-10, oxidation is conducted by the oxygen, and separation and purification are conducted after the oxidation is finished, so that the xylonic acid is obtained. According to the invention, the activated carbon is used as the catalyst of the synthetic method, so that the catalyst costs are lower than that of conventional heavy metals and the catalyst cannot be inactivated, and the catalyst can be used repeatedly; the speed of an oxidation reaction by using the oxygen is rapid, and the efficiency is high, so that the production costs are effectively reduced; and the purity of the xylonic acid crystal is equal to or more than 99%, the product quality is improved, resources are saved, and the effects are improved.

Description

technical field [0001] The invention relates to the field of xylonic acid production, in particular to a method for synthesizing xylonic acid. Background technique [0002] Xylose acid is a new chemical product that has emerged in recent years. It can effectively regulate the effective circulation and metabolism of vitamin C in the body. It can be used as a plant growth regulator and aquaculture additive, and can also be used as a cement binder. [0003] At present, the synthesis of xylonic acid is obtained by oxidation of xylose, and the main methods include iodine oxidation, palladium oxidation, and biocatalytic oxidation. [0004] The literature of The Development of Cement and Concrete Additive focuses on the palladium oxidation method and microbial oxidation method. Due to the high price of heavy metals, high environmental pollution, harsh reaction conditions, long culture period and harsh culture conditions of natural strains, their large-scale commercialization is lim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/105C07C51/235C07C51/42
CPCC07C51/235C07C51/42C07C59/105
Inventor 唐一林江成真高绍丰韩文彬靳丛丛
Owner JINAN SHENGQUAN GROUP SHARE HLDG
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