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A kind of fermentation extraction method of American ginseng/ginseng extract with auxiliary blood pressure lowering effect

A technology of ginseng extraction and extraction method, which is applied in the extraction field of American ginseng/ginseng extract, can solve the problems of renal function damage, side effects of patients, etc., and achieve the effect of good blood pressure lowering effect, simple operation, and good blood pressure lowering effect

Active Publication Date: 2018-04-06
东方红西洋参药业(通化)股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used drugs that inhibit ACEI, such as captopril, enalapril, delapril and other drugs, these drugs are effective, but long-term use will cause a series of side effects in patients, which will greatly damage the renal function

Method used

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  • A kind of fermentation extraction method of American ginseng/ginseng extract with auxiliary blood pressure lowering effect
  • A kind of fermentation extraction method of American ginseng/ginseng extract with auxiliary blood pressure lowering effect

Examples

Experimental program
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Effect test

Embodiment 1

[0036] (1) Raw material processing: American ginseng is used as raw material, pulverized, puffed at 120°C, and set aside.

[0037] (2) Primary fermentation: Add 60u / g (based on the total mass of American ginseng) cellulase to the puffed American ginseng, then heat to 50°C and keep constant temperature, stir at 150r / min, decompose and ferment for 5 hours. After the fermentation is finished, filter with a 16-mesh centrifugal filter to obtain the enzymatic hydrolyzate of American ginseng. Heat the enzymatic hydrolyzate of American ginseng to 90°C, inactivate it for 30 minutes, and set it aside.

[0038] (3) Secondary fermentation: use flour as a carbon source and casein as a nitrogen source to prepare a culture medium, inoculate the Aspergillus oryzae liquid into the culture medium at a ratio of 1:100, and culture it on a shaking table at 35°C for 6 hours, that is, Aspergillus oryzae culture solution can be obtained, and the Aspergillus oryzae culture solution has a concentratio...

Embodiment 2

[0042] (1) Raw material processing: American ginseng is used as raw material, pulverized, puffed at 120°C, and set aside.

[0043] (2) Primary fermentation: Add 60u / g (based on the total mass of American ginseng) cellulase to the puffed American ginseng, then heat to 50°C and keep constant temperature, stir at 150r / min, decompose and ferment for 5 hours. After the fermentation is finished, filter with a 16-mesh centrifugal filter to obtain the enzymatic hydrolyzate of American ginseng. Heat the enzymatic hydrolyzate of American ginseng to 90°C, inactivate it for 30 minutes, and set it aside.

[0044] (3) Secondary fermentation: use flour as a carbon source and casein as a nitrogen source to prepare a culture medium, inoculate the Aspergillus oryzae liquid into the culture medium at a ratio of 1:100, and culture it on a shaking table at 35°C for 6 hours, that is, Aspergillus oryzae culture solution can be obtained, and the Aspergillus oryzae culture solution has a concentratio...

Embodiment 3

[0048] (1) Raw material processing: American ginseng is used as raw material, pulverized, puffed at 120°C, and set aside.

[0049] (2) Primary fermentation: Add 60u / g (based on the total mass of American ginseng) cellulase to the puffed American ginseng, then heat to 50°C and keep constant temperature, stir at 150r / min, decompose and ferment for 5 hours. After the fermentation is finished, filter with a 16-mesh centrifugal filter to obtain the enzymatic hydrolyzate of American ginseng. Heat the enzymatic hydrolyzate of American ginseng to 90°C, inactivate it for 30 minutes, and set it aside.

[0050] (3) Secondary fermentation: use flour as a carbon source and casein as a nitrogen source to prepare a culture medium, inoculate the Aspergillus oryzae liquid into the culture medium at a ratio of 1:100, and culture it on a shaking table at 35°C for 6 hours, that is, Aspergillus oryzae culture solution can be obtained, and the Aspergillus oryzae culture solution has a concentratio...

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Abstract

The invention discloses a method for fermenting and extracting American ginseng / ginseng extract which has the effect of assisting in lowering blood pressure. Primary fermentation: Use cellulase to enzymatically hydrolyze the puffed American ginseng / ginseng to obtain the American ginseng / ginseng enzymatic hydrolyzate, then inactivate the American ginseng / ginseng enzymatically hydrolyzate, and sieve it for later use; (3) Secondary Fermentation: Prepare fermentation medium with American ginseng / ginseng enzymatic hydrolyzate, carbon source, nitrogen source and water, then inoculate Aspergillus oryzae liquid, and ferment at 40-50°C for 2-3 days to obtain enzyme liquid; (4) Concentration: The obtained enzyme solution is filtered, and the obtained supernatant is concentrated to obtain American ginseng / ginseng extract. The American ginseng / ginseng extract obtained by the method has better antihypertensive effect and high safety.

Description

technical field [0001] The invention relates to a method for extracting American ginseng / ginseng extract, in particular to a method for fermenting and extracting American ginseng / ginseng extract which has the effect of assisting in lowering blood pressure. Background technique [0002] Hypertension is a common cardiovascular disease with a genetic predisposition. Taking medicine can only be controlled temporarily, and long-term taking also has the side effect of impairing liver and kidney function. Therefore, there have been many functional foods that can assist in lowering blood pressure. Such as: CN20131021150.6 "An instant powder with auxiliary blood pressure lowering effect and its preparation method" is made of tartary buckwheat flour, kudzu root extract, cassia seed extract, hawthorn extract, wolfberry extract, earthworm extract, Prunella vulgaris Made from extract, soybean lecithin, non-dairy creamer, etc. CN20081023576.7 "Preparation method and application of corn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/14C07K1/12C12P1/00C12P21/02A23L33/105A23L29/00A61K36/258A61P9/12C12R1/69
CPCA23V2002/00A61K36/258A61K2236/19A23L29/06A23L33/105C12P1/00C12P21/02C12N1/145C12R2001/69A23V2200/326A23V2250/21A23V2250/2124
Inventor 陈云行胡道钜杨静雯
Owner 东方红西洋参药业(通化)股份有限公司