Nanostructure lipid carrier coated with sun-screening agent and preparation method and application thereof

A nano-lipid carrier and sunscreen technology, which is applied in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve problems such as unsuitable for large-scale production, uneven particle size distribution, and large particle size , to achieve the effects of easy large-scale production, good storage stability, and uniform particle size

Active Publication Date: 2017-11-17
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ultrasonic equipment is common and easy to operate, but the metal probe of the ultrasonic equipment will leave metal on the product and contaminate the product
The second point is that this method is not suitable for large-scale production and the prepared particles have large particle size and uneven particle size distribution.
However, at the technical level of NLC, there is a lot of room for development in the depth and breadth of research on coated sunscreens
There are not many experiments on the encapsulation of different sunscreen agents commonly used in China, and what lipid materials, surfactants, and methods to choose to achieve high encapsulation efficiency and good sunscreen performance

Method used

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  • Nanostructure lipid carrier coated with sun-screening agent and preparation method and application thereof
  • Nanostructure lipid carrier coated with sun-screening agent and preparation method and application thereof
  • Nanostructure lipid carrier coated with sun-screening agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A nano-lipid carrier for coating a sunscreen, comprising the following components by mass percentage:

[0057]

[0058] Wherein, the content of the liquid lipid caprylic capric triglyceride is 25% of the total oil content, and the content of the solid lipid cetyl palmitate is 75% of the total oil content;

[0059] The preparation method of the nano-lipid carrier of the coating sunscreen agent comprises the following steps:

[0060] (1) mixing solid lipid cetyl palmitate, liquid lipid caprylic capric triglyceride, sunscreen (UVA sunscreen BP-3 and UVB sunscreen OMC mass ratio 1:4) to obtain an oil phase; The emulsifier (A165, poloxamer and soybean lecithin mass ratio 3:3:1) is mixed with water to obtain an aqueous phase;

[0061] (2) Heat the water phase and oil phase prepared in step (1) through a water bath for 20 minutes to the same emulsification temperature of 80°C; add the oil phase to the water phase at the same temperature, and use Ultra-Turrax T25 high-shear...

Embodiment 2

[0063] A nano-lipid carrier for coating a sunscreen, comprising the following components by mass percentage:

[0064]

[0065] Wherein, the content of the liquid lipid caprylic capric triglyceride is 30% of the total oil content, and the content of the solid lipid cetyl palmitate is 70% of the total oil content;

[0066] The preparation method of the nano-lipid carrier of the coating sunscreen agent comprises the following steps:

[0067] (1) mixing solid lipid cetyl palmitate, liquid lipid caprylic capric triglyceride, sunscreen (UVA sunscreen BP-3 and UVB sunscreen OMC mass ratio 1:4) to obtain an oil phase; The emulsifier (A165, poloxamer and soybean lecithin mass ratio 3:3:1) is mixed with water to obtain an aqueous phase;

[0068] (2) Heat the water phase and oil phase prepared in step (1) through a water bath for 20 minutes to the same emulsification temperature of 80°C; add the oil phase to the water phase at the same temperature, and use Ultra-Turrax T25 high-shear...

Embodiment 3

[0070] A nano-lipid carrier for coating a sunscreen, comprising the following components by mass percentage:

[0071]

[0072] Wherein, the content of the liquid lipid caprylic capric triglyceride is 35% of the total oil content, and the content of the solid lipid cetyl palmitate is 65% of the total oil content;

[0073] The preparation method of the nano-lipid carrier of the coating sunscreen agent comprises the following steps:

[0074] (1) mixing solid lipid cetyl palmitate, liquid lipid caprylic capric triglyceride, sunscreen (UVA sunscreen BP-3 and UVB sunscreen OMC mass ratio 1:4) to obtain an oil phase; The emulsifier (A165, poloxamer and soybean lecithin mass ratio 3:3:1) is mixed with water to obtain an aqueous phase;

[0075] (2) Heat the water phase and oil phase prepared in step (1) through a water bath for 20 minutes to the same emulsification temperature of 80°C; add the oil phase to the water phase at the same temperature, and use Ultra-Turrax T25 high-shear...

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Abstract

The invention belongs to the field of cosmetics and particularly relates to a nanostructure lipid carrier coated with a sun-screening agent and a preparation method and application thereof. The nanostructure lipid carrier coated with the sun-screening agent includes the following components of solid lipids, liquid lipids, the sun-screening agent, emulsifiers and water. The high-pressure homogenization method is adopted, the solid lipids, the liquid lipids and the emulsifiers are selected, the nanostructure lipid carrier is coated with benzophenone-3 and iso-octyl p-methoxycinnamate simultaneously, and thus the nanostructure lipid carrier coated with the sun-screening agent is obtained. The prepared nanostructure lipid carrier coated with the sun-screening agent is small in particle size, low in distribution coefficient, high in Zeta potential, stable in NLC system, good in dispersity and not liable to agglomerate and has properties of good storage stability, good ultraviolet absorbency, good illumination stability and the like.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to a nano-lipid carrier coated with a sunscreen agent and a preparation method and application thereof. Background technique [0002] With the abundance of social material resources, people pay more and more attention to the protection of sun protection. Therefore, the characteristics and safety issues of sunscreen products have become one of the daily focuses of people. The safety, stability, low irritation and hypoallergenicity of sunscreen products have always been the direction of the world. [0003] Coating technology can improve the stability, safety and performance of sunscreens in the research and application of sunscreens. And finding a suitable carrier to coat and improve sunscreens has always been a hot spot. In the 20th century, with the application and promotion of nanotechnology, it brought many new carrier systems. Such as liposomes, solid lipid nanoparticles ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61Q17/04A61K8/35A61K8/37A61K8/92
CPCA61K8/14A61K8/35A61K8/37A61K8/375A61K8/922A61K8/927A61K2800/412A61K2800/596A61Q17/04
Inventor 郑成凌慧钟景明毛桃嫣
Owner GUANGZHOU UNIVERSITY
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