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Chinese medicine compound rectal administration temperature-sensitive gel and preparing method thereof

A technology of temperature-sensitive gel and rectal administration, which is applied in the directions of medical formula, drug combination, drug delivery, etc. It can solve the problems of unfavorable clinical application, large dosage of patients, waste of drug resources, etc., and achieves no toxic side effects and long retention time , Accelerate dredging effect

Inactive Publication Date: 2017-11-24
江西医学高等专科学校
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the original medicinal materials are directly used in medicine, it is not conducive to absorption and affects the curative effect, and at the same time it causes a waste of drug resources. In addition, the dosage of patients is also large, which is not conducive to clinical application.

Method used

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  • Chinese medicine compound rectal administration temperature-sensitive gel and preparing method thereof
  • Chinese medicine compound rectal administration temperature-sensitive gel and preparing method thereof
  • Chinese medicine compound rectal administration temperature-sensitive gel and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The traditional Chinese medicine compound rectal administration temperature-sensitive gel for the treatment of chronic non-bacterial prostatitis of the present embodiment is made by adding an appropriate amount of auxiliary materials from the main drug extract. Calamus 15g, licorice 40g, black medicine 20g and Yizhiren 10g. The technological process of the main drug extract is as follows: crush the above-mentioned fennel, calamus, licorice, black medicine, and Yizhiren into coarse powder, add 40g of water to soak for 30 minutes, and then use water to decoct for extraction; the number of extractions is 3 times, and the extraction The time is 1 hour each time, and the amount of water for extraction is 8 times of each time (that is, equivalent to 8 times of the total weight of the extracted medicinal materials). The three extracts are combined, concentrated and dried to obtain the extract powder, that is, the main drug extract.

[0031] Get 60g of the main drug extract, ad...

Embodiment 2

[0035] The preparation of the main drug extract is the same as in Example 1.

[0036] Take the main drug extract 120g, add auxiliary materials, the amount of auxiliary materials is poloxamer 407 80g, poloxamer 188 1.5g, ethyl p-hydroxybenzoate 1.2g, propyl p-hydroxybenzoate 1.2g, hydroxypropyl methyl Base cellulose E15 23.5g, borneol 20g, purified water 210g.

[0037] Add the prescribed amount of Poloxamer 407 and Poloxamer 188 into 168g of purified water, and wait for the swelling to be complete at 4°C, then add hypromellose E15, ethyl p-hydroxybenzoate, and p-hydroxybenzoic acid Propyl ester and borneol were stirred to dissolve to obtain a blank thermosensitive gel.

[0038] Add the main drug extract obtained above into the blank thermosensitive gel, stir to dissolve it, add 42 g of purified water, stir to make it uniform, and obtain the traditional Chinese medicine compound rectal thermosensitive gel.

Embodiment 3

[0040] The preparation of the main drug extract is the same as in Example 1.

[0041]Take 60g of the main drug extract, add auxiliary materials, the amount of auxiliary materials is poloxamer 407 120g, poloxamer 188 20g, ethyl p-hydroxybenzoate 2.5g, propyl p-hydroxybenzoate 2.5g, hydroxypropyl methyl Cellulose E15 4.5g, borneol 10g, purified water 250g.

[0042] Add the prescribed amount of Poloxamer 407 and Poloxamer 188 into 200 g of purified water, and wait until it swells completely at 4°C, then add hypromellose E15, ethyl p-hydroxybenzoate, and p-hydroxybenzoic acid Propyl ester and borneol were stirred to dissolve to obtain a blank thermosensitive gel.

[0043] Add the main drug extract obtained above into the blank thermosensitive gel, stir to dissolve it, add 50 g of purified water, stir to make it uniform, and obtain the traditional Chinese medicine compound thermosensitive gel for rectal administration.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a Chinese medicine compound rectal administration temperature-sensitive gel. The Chinese medicine compound rectal administration temperature-sensitive gel comprises, by weight, 1-40% of main medicine extract, 5-30% of temperature-sensitive gel matrix, 0.05-10% of tackifier, 0.01-5% of preservative, 0.1-5% of penetration enhancer, and the balance water. The invention further discloses a preparing method for the temperature-sensitive gel. The preparing method for the temperature-sensitive gel comprises the following steps that two or more than two kinds of powder mulberry, prickly heat, lindera aggregata and licorice are mixed according to certain proportion, extracting solvent is added for extracting, the extracting solution is concentrated and dried, and the main medicine extract is obtained; temperature-sensitive gel matrix is added into purified water for swelling completely, the tackifier, the preservative and penetration enhancer are added, and a blank temperature-sensitive gel is obtained; the main medicine extract is added into the blank temperature-sensitive gel for dissolving by stirring, purified water is added, and the temperature-sensitive gel is obtained after evenly stirring. The temperature-sensitive gel has a suitable phase transition temperature and the preparation method is simple.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a temperature-sensitive gel for rectal administration of traditional Chinese medicine compound and a preparation method thereof. Background technique [0002] Chronic prostatitis is a syndrome caused by different reasons, including chronic bacterial prostatitis, chronic non-bacterial prostatitis and prostatic pain, so some people call it chronic prostatitis syndrome. It is a common disease in adult men, and about 30%-50% of men have suffered from prostatitis at some point in their lives. One of the reasons why chronic prostatitis is difficult to treat is the plasma-prostate barrier, which reduces the concentration of drugs penetrating into the prostatic ducts, acini and prostatic fluid. In addition, the pathological changes of prostatitis itself and the fibrosis around the lesion also affect the diffusion of drugs, resulting in the fact that mos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K36/9062A61P13/08
CPCA61K9/0031A61K9/06A61K36/484A61K36/54A61K36/888A61K36/8945A61K36/9062A61K47/38A61K2300/00
Inventor 叶颖俊叶锡勇徐子金杨宇秀刘建明陈慧
Owner 江西医学高等专科学校
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