MOP-nanorod with mimetic enzyme property as well as preparation method and application of MOP-nanorod

A nanorod and enzyme-mimicking technology, applied in the chemical field, can solve problems such as difficulties in practical application and unsatisfactory catalytic effects of simulated enzymes, and achieve the effects of easy separation and purification, and simple synthesis methods

Inactive Publication Date: 2017-11-24
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional simulated enzymes such as heme also have certain applications, but there is a prominent problem, that is, compared with na

Method used

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  • MOP-nanorod with mimetic enzyme property as well as preparation method and application of MOP-nanorod
  • MOP-nanorod with mimetic enzyme property as well as preparation method and application of MOP-nanorod
  • MOP-nanorod with mimetic enzyme property as well as preparation method and application of MOP-nanorod

Examples

Experimental program
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Effect test

Embodiment 1

[0045] A method for preparing MOP-nanometer rods with enzyme-mimicking properties, comprising the steps of:

[0046] Dissolve 5-bromoisophthalic acid (0.2mmol) and copper nitrate trihydrate (0.22mmol) in 4.6 mL of a mixed solvent of methanol and DMF (the volume ratio of methanol to DMF in the mixed solvent v:v=3.8: 1), put the above solution in a 25ml round bottom flask, and heat the reaction at 70°C for 1.8 days.

[0047] The obtained product was separated by centrifugation, the precipitate was washed 5 times with methanol, and after natural drying, water was added, soaked in water for 1.8 days and washed, and dried in vacuum at a temperature of 30°C to obtain MOP-nanorods. The X-ray diffraction pattern was as follows: figure 2 As shown, it can be seen from the figure that all have crystal forms after synthesis, which are crystals. SEM images of MOP-nanorods image 3 shown by image 3 It can be seen that the shape of the MOP-nanorod is rod-shaped and relatively uniform, w...

Embodiment 2

[0049] A method for preparing MOP-nanometer rods with enzyme-mimicking properties, comprising the steps of:

[0050] Dissolve 5-nitroisophthalic acid (0.2mmol) and copper nitrate trihydrate (0.26mmol) in a mixed solvent of 5.6mL methanol and DMF (the volume ratio of methanol to DMF in the mixed solvent v:v=4.2: 1), put the above solution in a 25ml round bottom flask, and heat the reaction at 80°C for 2.5 days.

[0051] The resulting product was centrifuged, the precipitate was washed 6 times with methanol, dried, added water, soaked in water for 2.2 days and washed, and dried in vacuum at a temperature of 40°C to obtain MOP-nanorods. The X-ray diffraction pattern is as follows: figure 2 As shown, it can be seen from the figure that all have crystal forms after synthesis, which are crystals.

Embodiment 3

[0053] A method for preparing MOP-nanometer rods with enzyme-mimicking properties, comprising the steps of:

[0054] Dissolve 5-hydroxyisophthalic acid (0.2mmol) and copper nitrate trihydrate (0.2mmol) in methanol (4mL) and DMF (1mL) (N,N-dimethylformamide) (v:v= 4:1), the above solution was placed in a 25ml round bottom flask, and heated at 75°C for 2 days.

[0055] The resulting product was centrifuged, the precipitate was washed 5 times with methanol, dried, added water, soaked in water for 2 days and washed, and dried in vacuum at a temperature of 35°C to obtain MOP-nanorods. The X-ray diffraction pattern is as follows: figure 2 As shown, it can be seen from the figure that all have crystal forms after synthesis, which are crystals.

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Abstract

The invention relates to an MOP-nanorod with mimetic enzyme property as well as a preparation method and application of the MOP-nanorod and belongs to the technical field of chemistry. The preparation method of the MOP-nanorod comprises the following steps: heating and reacting a 5-substituted m-phthalic acid derivative shown as a formula (I) and a copper nitrate trihydrate in an organic solvent at the temperature of 75 DEG C, performing alcohol-washing on the obtained product and drying, soaking and washing in water, and drying to obtain the product, wherein the structural formula is as shown in the specification, in the formula (I), -R is -H, -Br, -NO2, -OH or -CH=CH2. Compared with most of the conventional mimetic enzymes, the MOP-nanorod disclosed by the invention is simple and convenient in synthetic method, and the product is easily separated and purified, has wider pH application range and particularly has high catalytic activity at the pH value of 6-10, and the application of the mimetic enzyme system can be further enriched.

Description

technical field [0001] The invention belongs to the technical field of chemistry, and in particular relates to a MOP-nanometer rod with enzyme-simulating properties, a preparation method and application thereof. Background technique [0002] Natural enzyme is a kind of biocatalyst, which is a kind of protein with catalytic function that widely exists in living organisms. It has the properties of a broad-spectrum enzyme and its own characteristics: such as higher catalytic efficiency, higher reaction Specificity and mild reaction conditions; some enzymes (such as dehydrogenase) require coenzymes or prosthetic groups, and have unique ability to regulate enzyme activity. However, the complex structure of natural enzymes will be deactivated by protease hydrolysis variability, the reaction conditions are generally mild (pH, temperature, etc.), which is not conducive to practical application, and the purification is difficult and expensive, which brings inconvenience to storage an...

Claims

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Application Information

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IPC IPC(8): C07C51/00C07C63/68C07C65/03C07C63/64C07C63/24C07C201/12C07C205/57B01J31/22G01N21/78
CPCB01J31/2213B01J2531/0213B01J2531/0241B01J2531/16C07C51/00C07C63/24C07C63/64C07C63/68C07C65/03C07C201/12C07C205/57G01N21/78
Inventor 郑立炎秦渝
Owner YUNNAN UNIV
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