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Preparation method of polyphosphazene polymer microspheres

A technology of polymer microspheres and polyphosphazene is applied in the field of functional materials to achieve the effects of wide application prospect, convenient operation and simple reaction process

Inactive Publication Date: 2017-11-28
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the above methods are not commonly used in the preparation of polymer microspheres, the technology of preparing high-performance polymer microspheres with uniform shape and controllable size is still a major difficulty and hot spot at present.

Method used

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  • Preparation method of polyphosphazene polymer microspheres

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Add 50 mL of acetonitrile, 0.1 g of 4,4'-dihydroxydiphenyl sulfone, 0.18 g of bisphenol AF and 0.5 mL of triethylamine into a three-necked flask, and heat at 90 o C, stirring at 200 r / min, condensing and refluxing;

[0017] (2) Add 0.2 g of hexachlorotrimeric phosphazene into the three-necked flask in step (1), stir, condense and reflux, and react for 1 h;

[0018] (3) The product of step (2) was cooled to room temperature, then centrifuged, washed with acetone, ethanol and distilled water, and finally dried in vacuum for 24 h.

[0019] The particle size of the prepared polyphosphazene microspheres was 500 nm.

Embodiment 2

[0021] (1) Add 50 mL of acetone-acetonitrile mixed solution (the volume ratio of acetone and acetonitrile is 1:1), 0.13 g of 4,4'-dihydroxydiphenyl sulfone, 0.1 g of bisphenol AF and 1.0 mL of trioctyl Amine, heating temperature is 20 o C, stirring at 200 r / min, condensing to reflux;

[0022] (2) Add 0.3 g of hexachlorotrimeric phosphazene into the three-necked flask in step (1), stir, condense and reflux, and react for 3 h;

[0023] (3) The product of step (2) was cooled to room temperature, then centrifuged, washed with acetone, ethanol and distilled water, and finally dried in vacuum for 24 h.

[0024] The prepared polyphosphazene microspheres had a particle size of 1.5 µm

Embodiment 3

[0026] (1) Add 50 mL of acetone solution, 0.25 g of 4,4'-dihydroxydiphenyl sulfone, 0.05 g of bisphenol AF and 1.5 mL of trioctylamine into a three-necked flask, and heat at 50 o C, stirring at 200 r / min, condensing and refluxing;

[0027] (2) Add 0.2 g of hexachlorotrimeric phosphazene into the three-necked flask in step (1), stir, condense and reflux, and react for 4 h;

[0028] (3) The product of step (2) was cooled to room temperature, then centrifuged, washed with acetone, ethanol and distilled water, and finally dried in vacuum for 24 h.

[0029] The particle size of the prepared polyphosphazene microspheres was 2.7 µm.

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Abstract

The invention discloses a preparation method of polyphosphazene polymer microspheres, belonging to the technical field of functional materials. According to the preparation method, a precipitation polymerization method is adopted, phosphonitrilic chloride trimer, 4,4'-dihydroxydiphenylsulfone and bisphenol AF are taken as monomers, a solution A (acetonitrile, acetone or a mixed solution of the acetone and the acetonitrile) is taken as a solvent, triamine alkane compounds such as trioctylamine and triethylamine are taken as acid binding agents, and the phosphonitrilic chloride trimer, the 4,4'-dihydroxydiphenylsulfone and the bisphenol AF are initiated to polymerize, so that the monodisperse polyphosphazene polymer microspheres which are uniform in morphology and have the controllable sizes of 500nm-5.5mu m can be prepared. The preparation method is simple, the reaction temperature is 20-90 DEG C, the reaction time is 1-8h, and the prepared microspheres are uniform in morphology and particle sizes and stable in structure. The microspheres provided by the invention can stably exist in solvents such as water and ethanol; the surfaces of the microspheres contain a great deal of active groups, so that surface modification and further modification are facilitated; therefore, the polyphosphazene polymer microspheres have a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a preparation method of polyphosphazene polymer microspheres. Background technique [0002] Polymer microspheres refer to polymer aggregates whose diameters range from nanometers to micrometers and whose shape is spherical. On the one hand, polymer microspheres have the advantages of large specific surface area, strong surface adsorption performance, and designability of aggregate structure composition. At the same time, the particle size is controllable and the shape is diverse. It has broad application prospects in the fields of detection and separation, interaction with biomolecules, detection of cell activity, synthesis of polypeptide chemicals, and immobilization of antibodies or antigens. With the continuous development of polymer microsphere preparation technology, it has developed from traditional emulsion polymerization, suspension polymerizatio...

Claims

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Application Information

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IPC IPC(8): C08G79/025C08J3/12
CPCC08G79/025C08J3/12C08J2385/02
Inventor 游力军王傲黄慈张其清
Owner FUZHOU UNIVERSITY
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