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Application of lactobacillus plantarum in preventing intestinal barrier injury

A technology of Lactobacillus plantarum and intestinal barrier, applied in the biological field, can solve the problem of no specific medicine for intestinal barrier

Inactive Publication Date: 2017-12-01
JILIN ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no specific drug for the treatment of intestinal barrier function damage. Generally, more attention is paid to the treatment of the primary disease. Try to achieve early accurate diagnosis and early effective treatment to minimize the incidence of intestinal mucosal barrier damage. Glutamine, recombinant human growth hormone , traditional Chinese medicine, etc. also have a certain protective effect on the intestinal mucosal barrier

Method used

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  • Application of lactobacillus plantarum in preventing intestinal barrier injury
  • Application of lactobacillus plantarum in preventing intestinal barrier injury
  • Application of lactobacillus plantarum in preventing intestinal barrier injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1, isolation, identification and preservation of bacterial strains

[0074] 1. Isolation of strains

[0075] Sample material: traditional fermented sauerkraut.

[0076] After repeated streaking culture on the BCP medium plate, pick a single colony producing yellow circles and inoculate it on the MRS medium plate to continue culturing, and then repeatedly streak culture and purify on the MRS medium plate to obtain multiple strains of pure culture strains.

[0077] The purely cultured strains were inoculated into liquid MRS medium for culture, then added 20% glycerol, and stored in a -80°C refrigerator.

[0078] After positive Gram staining, negative catalase test, negative indole reaction, negative hydrogen sulfide production test, negative gelatin liquefaction test, negative hydrolyzed starch test and negative nitrate reduction test, multiple strains were screened from purely cultured strains. Lactobacillus strains. One of the Lactobacillus plantarum strai...

Embodiment 2

[0087] Example 2, the application of Lactobacillus plantarum Sc52 in improving the intestinal barrier

[0088] 1. Preparation of bacterial suspension

[0089] Take the cells of Lactobacillus plantarum Sc52 and suspend them with sterile physiological saline to obtain a bacterial concentration of 1×10 10 CFU / mL bacterial suspension A.

[0090] Take the cells of Lactobacillus plantarum CICC-6009 and suspend them with sterile saline to obtain a bacterial concentration of 1×10 10 CFU / mL of bacterial suspension B.

[0091] Two, group processing

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Abstract

The invention discloses an application of lactobacillus plantarum in preventing intestinal barrier injury. First, the application of the lactobacillus plantarum in preventing the intestinal barrier injury protects the application of the lactobacillus plantarum in prepared products. Functions of the products are (a1) and / or (a2) and / or (a3) and / or (a4), specifically, (a1) intestinal mucosa is protected; (a2) intestinal mucosal injury is prevented and / or treated; (a3) intestinal barrier is protected; and (a4) intestinal barrier injury is prevented and / or treated. The products are microbial agents, medicines, health products or foods. The inventor of the application of the lactobacillus plantarum in preventing the intestinal barrier injury finds that lactobacillus plantarum Sc52 can help to maintain the integrality of the intestinal mucosal barrier function and has the outstanding excellent effect on relieving the intestinal barrier injury; daily intake of lactobacillus plantarum Sc52 or antifungal agents of the lactobacillus plantarum Sc52 can replace the medicine to protect the integrity of the intestinal barrier function; and the application of the lactobacillus plantarum in preventing the intestinal barrier injury provides a new thought for clinical intervening and controlling of intestinal barrier function injury related diseases, and has broad application prospects and the popularizing value.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the application of plant lactobacillus in preventing intestinal barrier damage. Background technique [0002] The intestinal tract is the largest digestive organ in the human body. A complete intestinal mucosal barrier can prevent microorganisms and endotoxins from entering the body circulation. It is the first line of defense against intestinal bacteria and toxins. It plays an important role in maintaining the normal function of the intestinal tract and ensuring the health of the body. Once the intestinal mucosal barrier function is damaged, the intestinal permeability increases, and the endotoxin in the intestinal lumen breaks through the intestinal barrier and enters the body circulation, which promotes the release of a large number of inflammatory cytokines, causes inflammation in the body, and induces abnormal mucosal immune responses. [0003] In recent years, stud...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P1/00A61P1/04A23L33/135
CPCA61K35/747A23V2002/00A23V2400/169A23V2200/3204
Inventor 李盛钰赵玉娟段翠翠高磊牛春华栾畅李婷婷
Owner JILIN ACAD OF AGRI SCI
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