Hydrophilic super-lubricating coating applied to surfaces of medical apparatuses and preparation method of hydrophilic super-lubricating coating

A medical device and coating technology, applied in the field of hydrophilic ultra-slippery coating and its preparation, to achieve the effect of shortening curing time, increasing production efficiency and reducing production cost

Active Publication Date: 2017-12-01
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are very few hydrophilic super-slip coating products used on the surface of medical devices in China, and most of these products are monopolized by foreign countries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Polyurethane acrylate prepolymer 1, polyethylene glycol dipropionate 1000 (obtained by polyethylene glycol capping with a number average molecular weight of 1000), Irgacure 2959 are dissolved in a mixed solvent of ethanol and deionized water , stirring at room temperature for 1-2h in the dark to obtain a primer; wherein the mass ratio of polyurethane acrylate to polyethylene glycol dipropionate 1000 is 2:1, Irgacure 2959 accounts for 5% of the total mass of the primer after curing, ethanol Water accounts for 94% of the mass of the primer.

[0042] Dissolve polyethylene glycol diacrylate 1000, polyethylene glycol 20000 (number-average molecular weight: 20000), and Irgacure2959 in deionized water, and stir at room temperature for 1-2 hours in the dark to obtain a surface coating; wherein polyethylene glycol diacrylate The mass ratio of ester 1000 to polyethylene glycol 20000 is 1:4, the photoinitiator is 3% of the total mass of the surface coating after curing, and th...

Embodiment 2

[0048] (1) Polyurethane acrylate prepolymer 2, pentaerythritol tetraacrylate, and benzophenone are dissolved in ethanol, and stirred at room temperature in the dark for 1-2h to obtain a primer; wherein the mass ratio of polyurethane acrylate to pentaerythritol tetraacrylate The ratio is 1:1, the photoinitiator is 5% of the total mass of the primer after curing, and ethanol accounts for 85% of the mass of the primer.

[0049] Dissolve pentaerythritol tetraacrylate, polyvinylpyrrolidone K30 (number average molecular weight 45000-58000), benzophenone, and Irgacure 1173 in ionized water, and stir at room temperature for 1-2 hours in the dark to obtain a top coat; wherein pentaerythritol tetraacrylate The mass ratio to polyvinylpyrrolidone is 3:1, and deionized water accounts for 85% of the surface coating.

[0050] (2) Apply the primer to the surface of the medical device, irradiate with ultraviolet light for 20s, then apply the topcoat on the cured primer, and cure with UV for 32...

Embodiment 3

[0053] (1) Dissolve urethane acrylate prepolymer 3, polyethylene glycol diacrylate 600, and benzophenone in ethanol, and stir at room temperature in the dark for 1-2 hours to obtain a primer; wherein urethane acrylate and polyethylene glycol The mass ratio of alcohol diacrylate 600 is 1:1, benzophenone is 4% of the cured primer, and ethanol accounts for 75% of the primer mass.

[0054] Dissolve polyethylene glycol diacrylate 600, polyacrylic acid-acrylamide partial sodium salt, and benzophenone in a mixed solvent of ionized water and ethanol, and stir at room temperature for 1-2 hours in the dark to obtain a top coat; The mass ratio of alcohol diacrylate 600 to polyacrylic acid-acrylamide partial sodium salt is 1:4, the photoinitiator is 4% of the total mass of the surface coating after curing, and deionized water and ethanol account for 93% of the surface coating. The mass ratio of ionized water to ethanol is 1:1.

[0055] The partial sodium salt of polyacrylic acid-acrylami...

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PUM

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Abstract

The invention provides a hydrophilic super-lubricating coating applied to surfaces of medical apparatuses and a preparation method of the hydrophilic super-lubricating coating. The hydrophilic super-lubricating coating comprises a bottom layer and a surface layer, wherein on the basis of the principle of dissolution in similar material structures, the bottom layer and the base material (the surface layer) are firmly bonded; and the surface layer and the bottom layer are firmly connected by virtue of chemical bonds which are formed from ultraviolet grafting and inter-molecular forces. By virtue of a dipping-coating technology, the surfaces of the medical apparatuses are dipped in a bottom layer solution and are subjected to partial curing in ultraviolet radiation; and then, the medical apparatuses that the bottom layer is partially cured are dipped in a surface layer paint and are subjected to complete curing under ultraviolet rays, so that the surface layer is uniformly and stably distributed on the bottom layer. According to the hydrophilic super-lubricating coating and the preparation method provided by the invention, the hydrophilic super-lubricating paint can get rapidly cured under the ultraviolet rays, and the obtained hydrophilic coating is excellent in lubricating performance and durability, and friction and tissue injuries, which are caused in an inserting process, can be effectively relieved; and moreover, the hydrophilic super-lubricating coating is easily available in raw materials and low in cost.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a hydrophilic super-slip coating and a preparation method thereof. Background technique [0002] Interventional medicine is a low-invasive or minimally invasive technology. It has become one of the three major clinical medicines alongside surgery and internal medicine. Imaging equipment and interventional devices are the pillars of interventional medicine. [0003] Lubricity is one of the most important properties of interventional devices (catheters, guide wires). When inserting or pulling out of the human body, the surface of these instruments is required to be lubricated, so as to reduce damage and adhesion to the tissue and relieve the pain of the patient. At present, there are two ways to solve the problem of lubricity, one is to use lubricating oil, but the lubricity obtained by this treatment method is poor, it is difficult to last and it is not conducive to operation. One i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14
CPCA61L29/085A61L29/14A61L2420/06A61L2420/08C08L75/14
Inventor 蹇锡高王锦艳姜玲梅
Owner DALIAN UNIV OF TECH
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