A kind of hydrophilic modification coating on the surface of medical intervention catheter

Abstract

The invention discloses a hydrophilic modification material on the surface of a medical interventional catheter. The hydrophilic modification material is composed of transition layer coating and lubricating layer coating. The transition layer coating comprises, by weight, 5-10 parts of connection resin, 0.1-0.2 part of a first photoinitiator, 0.05-0.1 part of a flatting agent and 85-95 parts of first solvent. The lubricating layer coating comprises, by weight, 5-10 parts of hydrophilic resin, 1-5 parts of a waterborne cross-liner, 0.2-0.5 part of a second photoinitiator and 80-95 parts of second solvent. The hydrophilic modification material comprises a transition layer and a lubricating layer which are both photocuring coatings, the coating curing time is short, energy consumption is low, and batch production is facilitated.

Description

technical field [0001] The invention relates to a hydrophilic modified coating on the surface of a medical interventional catheter, which belongs to the field of medical interventional catheters. [0002] technical background [0003] Interventional catheters are one of the most commonly used medical devices and consumables in the medical process. The commonly used base materials are polyurethane, polyvinyl chloride, polyester, etc. These materials are all hydrophobic materials, which are easy to bond with tissues during use. It causes pain to the patient and is prone to infection. The hydrophilic modification of the interventional catheter can improve its lubricity, reduce the discomfort of the patient when the interventional catheter is used, and improve the safety of the interventional catheter. [0004] Regarding the design of hydrophilic modification and hydrophilic coating of interventional catheters, there are a large number of patent reports in China. For example, pa...

AI Technical Summary

Problems solved by technology

[0004] Regarding the design of hydrophilic modification and hydrophilic coating of interventional catheters, there are a large number of patent reports in China. For example, patent CN102993407A discloses a method for modifying polyurethane with a single-layer hydrophilic coating. The method first synthesizes a water-based polyurethane and then mixes it with N-vinylpyrrolidone and vinyl silicone have been copolymerized to prepare photocurable coatings. The hydrophilic coating prepared by this method may have NVP monomer residues after curing, and the friction coefficient after hydration is large; patent CN104448375A discloses a silicon A method for coating PVP on the surface of a PVC catheter after being modified by an oxane coupling agent, the hydrophilic coating prepared by this method has a low friction coefficient but poor adhesion after hydration; patent CN103933616A discloses a method for passing a catheter through plasma Grafting acrylic acid after treatment, and then coating the primer of water-based polyurethane and the modification method of the surface coating containing polymethyl vinyl ether-maleic anhydride, the hydrophilic coating obtained by this method has good adhesion, but due to containing acidic groups The dough needs to be neutralized with concentrated ammonia water, and there are too many preparation steps, and the processing process is cumbersome

Patent CN103289499A discloses a method for preparing a photocurable hydrophilic coating with a polymer chain containing a photoactive group-containing hydrophilic resin and a photoactive crosslinking agent. Active resin, the resin production and purification process is cumbersome, and the production cost is high