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A kind of hydrophilic modification coating on the surface of medical intervention catheter

A technology for hydrophilic modification and catheter intervention, applied in catheters, coatings, etc., can solve the problems of cumbersome resin production and purification process, low friction coefficient of hydrophilic coating, NVP monomer residue, etc., to achieve excellent stability, Effect of low friction coefficient and short curing time

Active Publication Date: 2020-01-24
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Regarding the design of hydrophilic modification and hydrophilic coating of interventional catheters, there are a large number of patent reports in China. For example, patent CN102993407A discloses a method for modifying polyurethane with a single-layer hydrophilic coating. The method first synthesizes a water-based polyurethane and then mixes it with N-vinylpyrrolidone and vinyl silicone have been copolymerized to prepare photocurable coatings. The hydrophilic coating prepared by this method may have NVP monomer residues after curing, and the friction coefficient after hydration is large; patent CN104448375A discloses a silicon A method for coating PVP on the surface of a PVC catheter after being modified by an oxane coupling agent, the hydrophilic coating prepared by this method has a low friction coefficient but poor adhesion after hydration; patent CN103933616A discloses a method for passing a catheter through plasma Grafting acrylic acid after treatment, and then coating the primer of water-based polyurethane and the modification method of the surface coating containing polymethyl vinyl ether-maleic anhydride, the hydrophilic coating obtained by this method has good adhesion, but due to containing acidic groups The dough needs to be neutralized with concentrated ammonia water, and there are too many preparation steps, and the processing process is cumbersome
Patent CN103289499A discloses a method for preparing a photocurable hydrophilic coating with a polymer chain containing a photoactive group-containing hydrophilic resin and a photoactive crosslinking agent. Active resin, the resin production and purification process is cumbersome, and the production cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] Preparation of transition layer coating: add 5-10 parts of bonding resin to 50 parts of solvent I, stir well and add 0.1-0.2 parts of photoinitiator I under the condition of avoiding light, and add 35-45 parts after the initiator is completely dissolved. One part of solvent I, adjust the viscosity to 4.0-5.0mPa·s, add 0.05-0.1 part of leveling agent, continue to stir for 30 minutes, and pack it for later use;

[0028] Preparation of lubricating layer coating: add 0.2-0.5 parts of photoinitiator Ⅱ to 70-80 parts of solvent Ⅱ, add 5-10 parts of hydrophilic resin and 1-5 parts of water-based crosslinking agent under constant stirring after fully dissolved Stir for 5-8 hours, measure the viscosity after forming a uniform solution, and adjust the viscosity to 90-120 mPa·s with 10-25 parts of solvent II.

[0029] An application of a hydrophilic modified coating on the surface of a medical intervention catheter, comprising the steps of:

[0030] Coating of transitional layer:...

Embodiment 1

[0035] Paint preparation:

[0036] Add 10 parts of unsaturated acrylic resin to 50 parts of ethyl acetate, and add 0.2 parts of 2-hydroxyl-4'-(2-hydroxyethoxy)-2-methyl propiophenone under the condition of avoiding light after fully stirring. After the initiator is completely dissolved, add 43 parts of isopropanol, measure the viscosity of the solution to 4.5 mPa·s, add 0.1 parts of leveling agent BYK333 and continue stirring for 30 minutes to obtain a transition layer coating; add 0.3 parts to 50 parts of ethanol and 25 parts of methanol Benzophenone, after being fully dissolved, add 3.5 parts of PVP, 1.5 parts of PEG and 1.0 parts of water-based cross-linking agent PEG400DA under uniform stirring for 7-8 hours, and measure the viscosity after forming a uniform solution, adjust with 10-20 parts of ethanol When the viscosity reaches 90-95 mPa·s, a lubricating layer coating is obtained.

[0037] Coating method:

[0038] Clean and dry the interventional catheter in medical eth...

Embodiment 2

[0042] Paint preparation:

[0043] Add 8 parts of unsaturated polyurethane acrylate resin to 25 parts of isopropanol and 25 parts of ethanol mixture, stir well and add 0.2 parts of 2-hydroxy-2-methyl-1-phenyl-1-acetone under dark conditions After the initiator is completely dissolved, add 40 parts of ethanol, measure the viscosity of the solution to be 5 mPa·s, add 0.05 parts of leveling agent DC57, and continue to stir for 30 minutes to obtain a transition layer coating; in 40 parts of water and 30 parts of ethanol mixed solution Add 0.5 parts of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, after fully dissolved, add 0.5 parts of PVA, 5.0 parts of PVP-PHEMA copolymer and 1.0 parts of water under constant stirring The joint agent PEG600DA is fully stirred for 7-8 hours, and the viscosity is measured after forming a uniform solution, and the viscosity is adjusted to 110-120 mPa·s with 15-25 parts of ethanol to obtain a lubricating layer coating.

[0044] Coating metho...

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Abstract

The invention discloses a hydrophilic modification material on the surface of a medical interventional catheter. The hydrophilic modification material is composed of transition layer coating and lubricating layer coating. The transition layer coating comprises, by weight, 5-10 parts of connection resin, 0.1-0.2 part of a first photoinitiator, 0.05-0.1 part of a flatting agent and 85-95 parts of first solvent. The lubricating layer coating comprises, by weight, 5-10 parts of hydrophilic resin, 1-5 parts of a waterborne cross-liner, 0.2-0.5 part of a second photoinitiator and 80-95 parts of second solvent. The hydrophilic modification material comprises a transition layer and a lubricating layer which are both photocuring coatings, the coating curing time is short, energy consumption is low, and batch production is facilitated.

Description

technical field [0001] The invention relates to a hydrophilic modified coating on the surface of a medical interventional catheter, which belongs to the field of medical interventional catheters. [0002] technical background [0003] Interventional catheters are one of the most commonly used medical devices and consumables in the medical process. The commonly used base materials are polyurethane, polyvinyl chloride, polyester, etc. These materials are all hydrophobic materials, which are easy to bond with tissues during use. It causes pain to the patient and is prone to infection. The hydrophilic modification of the interventional catheter can improve its lubricity, reduce the discomfort of the patient when the interventional catheter is used, and improve the safety of the interventional catheter. [0004] Regarding the design of hydrophilic modification and hydrophilic coating of interventional catheters, there are a large number of patent reports in China. For example, pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/14A61L29/04A61L29/08A61L29/06
CPCA61L29/041A61L29/06A61L29/085A61L29/14
Inventor 周峰马正峰蔡美荣
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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