Drug composite for curing diabetes and preparation method and application thereof

A composition and diabetes technology, applied in the field of medicine, can solve problems such as no research reports on anti-diabetic active ingredients, and achieve good hypoglycemic activity

Active Publication Date: 2017-12-08
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When Zheng Yuan isolated and purified Phellinus polysaccharide and studied its activity, she found that Phellinus polysaccharide has a good anti-aging effect, but there is no research report on the anti-diabetic active ingredients with small and medium polarity

Method used

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  • Drug composite for curing diabetes and preparation method and application thereof
  • Drug composite for curing diabetes and preparation method and application thereof
  • Drug composite for curing diabetes and preparation method and application thereof

Examples

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preparation example Construction

[0049] Wherein, the preparation method of Phellinus Phellinus dichloromethane extract comprises: extracting Phellinus Phellinus with alcohol-water mixed solution, and extracting Phellinus Phellinus obtained with petroleum ether and dichloromethane in sequence. Get Phellinus dichloromethane extract.

[0050] More specifically, the preparation method of Phellinus Phellinus dichloromethane extract is as follows: refluxing, impregnating or percolating Phellinus Phellinus powder with alcohol or alcohol-water mixture, and obtaining the extract after filtering; evaporating the solvent in the extract to obtain the extract Add water and stir the extract to obtain a suspension; finally, extract the suspension with petroleum ether to obtain petroleum ether extract and water-soluble parts, then extract the water-soluble parts with dichloromethane, concentrate , to obtain a dichloromethane extract.

[0051] Further, the preparation method of Phellinus polyphenols extract is as follows: pa...

Embodiment 1

[0070] This embodiment provides a pharmaceutical composition, which includes Phellinus polyphenols extract and pharmaceutically acceptable carriers or excipients.

[0071] Wherein, the preparation method of Phellinus polyphenols extract comprises:

[0072] Such as figure 1 As shown, take 2 kg of the dried Phellinus Phellinus strain, pulverize it with a pulverizer, then soak it in 80% ethanol aqueous solution for 3 days according to the solid-liquid ratio of 1:8 (1.0 kg medicinal material corresponds to 8.0 L of solvent), filter and get the filtrate, The filter residue was impregnated with 80% aqueous ethanol solution of the same volume for 3 days, repeated five times, filtered and combined the filtrates extracted five times, and concentrated under reduced pressure to obtain 340 g of yellow slurry.

[0073] Add water to dissolve and dilute at a volume ratio of 1:10, extract the sample with an equal volume of dichloromethane, concentrate the dichloromethane extract under reduce...

Embodiment 2

[0076] This embodiment provides a pharmaceutical composition, which includes Phellinus polyphenols extract and pharmaceutically acceptable carriers or excipients.

[0077] Wherein, the preparation method of Phellinus polyphenols extract comprises:

[0078] Such as figure 1 As shown, take 2 kg of the dried Phellinus phellifolia strain, pulverize it with a pulverizer, then soak it in 75% ethanol aqueous solution for 3 days according to the ratio of material to liquid (1.0 kg of medicinal material corresponds to 7.0 L of solvent), and filter to get the filtrate. The filter residue was impregnated with an equal volume of 75% ethanol aqueous solution for 3 days, repeated five times, filtered and combined the filtrates extracted five times, and concentrated under reduced pressure to obtain 340 g of a yellow slurry.

[0079] Add water to dissolve and dilute at a volume ratio of 1:11, extract the sample with an equal volume of dichloromethane, concentrate the dichloromethane extract ...

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Abstract

The invention provides a drug composite for curing diabetes and a preparation method and an application thereof, and belongs to the field of medicine. The drug composite for curing diabetes comprises at least one of Inoscavin C, 7,3'-dihydroxyl-5'-methoxyl isoflavone, 7,8-dihydroxy coumarin and 3,4-dihydroxy benzylidene acetone, and medically acceptable carriers or auxiliary materials. The application of the drug composite is wide and comprises that the drug composite is applied to preparing an agonist for promoting glucose uptake, preparing an agonist for using adenosine phosphate to activate protein kinase, preparing an agonist of glucose transport protein 4, and preparing a drug for curing or preventing diseases caused by metabolic disturbance or preparing health care products, a new treatment means and thought are provided for treatment of diseases caused by metabolic disturbance, and meanwhile new medical value of phellinus igniarius is further developed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition for treating diabetes and its preparation method and application. Background technique [0002] Phellinus, also known as Sangchen, Sanger, Husunyan, Phellinus, belongs to Basidiomycota, Phellinusigniarus (Phellinusigniarus). A large medicinal fungus on the trunk of a tree or the like. Phellinus Phellinus is slightly bitter and cold in nature and taste, and is mainly used in traditional medicine to treat symptoms such as prolapse of the anus, diarrhea with blood, women's strain, astringent pain in the umbilical abdomen, carbuncle ulceration, and bloody stranguria, and has the effects of transforming drink and stopping diarrhea. In the in-depth research and development of it, it was found that Phellinus has good anti-tumor effect and has a good reputation in the world. In addition, Phellinus also has various functions such as protecting the liver and treating g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/37A61K31/12A61K31/366A23L33/10C07D493/04C07D311/36C07D311/40C07D311/16A23L33/105
CPCA23L33/105A23V2002/00A61K31/12A61K31/352A61K31/366A61K31/37C07D311/16C07D311/36C07D311/40C07D493/04A23V2200/328A23V2200/3262A23V2200/326A23V2200/332
Inventor 杨新洲黄密郑思建赵平黄蕴
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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