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A technology of cephradine and composition, which is applied in the field of cephradine pharmaceutical composition, can solve the problems of easy hydrolysis, easy hydrolysis of cephradine, unstable chemical properties, etc., and achieve the effects of small pharmacological side effects, simple preparation process, and simple prescription
Inactive Publication Date: 2017-12-22
江苏宏梓新能源科技有限公司
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Problems solved by technology
[0003] Because cefradine is a β-lactamase antibiotic, its chemical properties are unstable and easily hydrolyzed, seriously affecting product quality and even drug safety
At present, the ma...
Method used
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Embodiment 1
[0013] A cefradine pharmaceutical composition, consisting of the following raw materials by weight: 40 parts of cefradine, 10 parts of cyclodextrin, 10 parts of pregelatinized starch, 2 parts of sodium bicarbonate, 0.5 part of citric acid, and 0.4 part of magnesium stearate , 2 parts of fatty acid sorbitan, 1 part of lecithin, 2 parts of PVC, 1 part of micropowder silica gel.
Embodiment 2
[0015] A cefradine pharmaceutical composition, consisting of the following raw materials by weight: 50 parts of cefradine, 20 parts of cyclodextrin, 20 parts of pregelatinized starch, 8 parts of sodium bicarbonate, 1.1 parts of citric acid, and 1 part of magnesium stearate , 8 parts of fatty acid sorbitan, 5 parts of lecithin, 6 parts of PVC, and 5 parts of micropowder silica gel.
Embodiment 3
[0017] A cefradine pharmaceutical composition, consisting of the following raw materials by weight: 45 parts of cefradine, 15 parts of cyclodextrin, 15 parts of pregelatinized starch, 5 parts of sodium bicarbonate, 0.8 part of citric acid, and 0.7 part of magnesium stearate , 5 parts of fatty acid sorbitan, 3 parts of lecithin, 4 parts of PVC, and 3 parts of micropowder silica gel.
[0018] The preparation of the invention is simple and scientific, the stability is good, and the pharmacological and toxic side effects are small; meanwhile, the preparation process of the invention is simple and suitable for large-scale production.
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Abstract
The invention discloses a cefradine pharmaceutical composition, which is prepared from the following raw materials in parts by weight: 40 to 50 parts of cefradine, 10 to 20 parts of cyclodextrin, 10 to 20 parts of pregelatinized starch, 2 to 8 parts of sodium hydrogen carbonate, 0.5 to 1.1 parts of citric acid, 0.4 to 1 part of magnesium stearate, 2 to 8 parts of fatty acid sorbitan, 1 to 5 parts of lecithin, 2 to 6 parts of PVC (polyvinyl chloride) and 1 to 5 parts of aerosil. The cefradine pharmaceutical composition is simple and scientific in prescription and high in stability, and has little pharmacological toxic or side effects; in addition, a preparation process is simple and suitable for large-scale production.
Description
technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a cefradine pharmaceutical composition. Background technique [0002] Cephalosporin antibiotics are semi-synthetic antibiotics made by concatenating the parent nucleus of 7-angicephalosporanic acid (7-ACA) of cephalosporins. This class of antibiotics has the advantages of broad antibacterial spectrum, strong bactericidal power, stability to gastric acid and β-lactamase, and less allergic reactions. Cefradine belongs to the first generation of cephalosporins, which is white or off-white crystalline powder, slightly odorous, slightly soluble in water, and almost insoluble in ethanol, chloroform and ether. [0003] Since cefradine is a β-lactamase antibiotic, its chemical properties are unstable and easily hydrolyzed, which seriously affects product quality and even drug safety. At present, the marketed preparations are required to be stored in a cool and dark place t...
Claims
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Application Information
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