Artificial corneal frame made of novel material and application thereof

A technology of artificial cornea and new materials, applied in medical science, eye implants, prostheses, etc., can solve the problems of poor biocompatibility, limited sources, insufficient compressive and bending strength, etc., and achieve good strength, good The effect of biocompatibility

Active Publication Date: 2017-12-22
陈小鸟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite routine local and/or systemic use of anti-rejection drugs after surgery, the rejection rate is still as high as 60%, and the graft survival rate is less tha...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Configure the powder ratio of 80 parts ZrO2 , 4.5 copies of Y 2 0 3 , 0.2 parts of Al 2 o 3 , 0.012 parts of SiO 2 , 0.03 parts of Na 2 O. The module was prepared by isostatic pressing at 300 MPa, and the holding time was 3 minutes. Group A is formed by one sintering, increasing to 1100°C at a rate of 100°C / hour. Then manual or 3D cutting is performed to form the artificial corneal skirt bracket. Group B is formed by secondary sintering. The first sintering temperature is increased to 850°C at a rate of 50°C / hour for manual or 3D cutting to form an artificial corneal skirt stent model set according to the phase transition volume change rate, and then the second sintering is performed at a rate of 50°C / hour The temperature was ramped up to 1100°C at a rate of one hour. The performance values ​​of Group A and Group B of obtained zirconia ceramic artificial corneal skirt stents are: density 6.2 and 7.1 g / cm, flexural strength 1121 and 1158 MPa, compressive strengt...

Embodiment 2

[0035] Configure the powder ratio of 85 parts ZrO 2 , 5 copies of Y 2 0 3 , 0.25 parts of Al 2 o 3 , 0.012 parts of SiO 2 , 0.03 parts of Na 2 O. The module was prepared by isostatic pressing at 300 MPa, and the holding time was 3 minutes. Group A is formed by one sintering, increasing to 1100°C at a rate of 80°C / hour. Then manual or 3D cutting is performed to form the artificial corneal skirt bracket. Group B is formed by secondary sintering. The first sintering temperature is increased to 850°C at a rate of 70°C / hour for manual or 3D cutting to form an artificial corneal skirt stent model set according to the phase transition volume change rate, and then the second sintering is performed at a rate of 60°C / hour The temperature was ramped up to 1100°C at a rate of one hour. The performance values ​​of Group A and Group B of the obtained zirconia ceramic artificial corneal skirt stents are: density 6.9 and 7.8 g / cm, flexural strength 1134 and 1151 MPa, compressive str...

Embodiment 3

[0037] Configure the powder ratio of 90 parts ZrO 2 , 5.5 copies of Y 2 0 3 , 0.3 parts of Al 2 o 3 , 0.09 parts of SiO 2 , 0.025 parts of Na 2 O. The module was prepared by isostatic pressing at 300 MPa, and the holding time was 3 minutes. Group A is formed by one sintering, increasing to 1100°C at a rate of 90°C / hour. Then manual or 3D cutting is performed to form the artificial corneal skirt bracket. Group B is formed by secondary sintering. The first sintering temperature is increased to 850°C at a rate of 70°C / hour for manual or 3D cutting to form an artificial corneal skirt stent model set according to the phase transition volume change rate, and then the second sintering is performed at 70°C o The rate of C / hour ramps up the temperature to 1100°C. The performance values ​​of Group A and Group B of the obtained zirconia ceramic artificial corneal skirt stents are: density 7.2 and 7.8 g / cm, flexural strength 1132 and 1114 MPa, compressive strength 2211 and 2231 ...

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Abstract

The invention relates to an artificial corneal frame made of a novel material. The artificial corneal frame is characterized in that the main material is zirconia ceramics. Better biocompatibility performance, mechanical strength and surgical effect can be achieved by using zirconia ceramics as the artificial corneal frame material and designing a cylinder skirt frame embedding adhesion mode, on the other hand, the artificial corneal skirt frame made by using zirconia ceramics as a raw material and a transparent cylinder body by using PMMA as a material are adhered by a photo-polymerization and chemical polymerization dual-cure resin adhesive technology, so that existing larger wound surface and clasp locking technology of secondary operation can be avoided. Therefore, the artificial corneal frame made of the novel material and application have the advantages of excellent biocompatibility, excellent mechanical strength and convenience in use.

Description

technical field [0001] The invention relates to a novel artificial cornea support, the use of zirconia ceramics in preparing such artificial support, and the application form in human body. Background technique [0002] The cornea is the transparent part at the front of the eye. It is the part with the largest contact area between the eyeball and the outside world. The entire refractive power accounts for 70% of the whole eyeball. Corneal damage from various infectious and non-infectious keratitis, corneal degeneration, corneal dystrophy, keratoconus, ocular trauma, and dry eye due to eyelid and tear causes can lead to permanent vision loss and even corneal blindness. Allogeneic corneal transplantation is currently an effective method for corneal blindness. According to the report of the World Health Organization, there are about 1.68 million patients with vision problems caused by corneal diseases in China, 30% of whom have complete vision loss. Despite routine local and / ...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/16A61F2/14
CPCA61F2/142A61L27/10A61L27/16A61L2430/16C08L33/12
Inventor 陈小鸟
Owner 陈小鸟
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