DSP+FPGA based local field potential real time detection analysis platform eliminating DBS artifacts

Abstract

The invention provides a DSP+FPGA based local field potential real time detection analysis platform eliminating DBS artifacts. According to the invention, advantages of efficient data operation and processing and high time sequence logic control of DSP and FPGA are taken in combination, a DSP and FPGA combined system is adopted as a lower computer for performing collection, amplification, filtering, characteristic extraction and analysis on local field potential signals and uploading local field potential information subjected to analysis and processing to an upper computer through a USB communication module for display. The upper computer can realize setting of a collection channel of the local field potential signals and switching between channel setting and a display function through interface writing. The invention has an effect that by adding the signal collection and pre-processing functions in a DBS electrode, direct collection and pre-processing of the local field potential signals are enabled in DBS implementation process and closed-loop DBS is made possible.

Description

technical field [0001] The invention relates to biomedical engineering technology, in particular to a DSP+FPGA-based real-time detection and analysis platform for local field potential without DBS artifacts. Background technique [0002] Parkinson's disease (Parkinson's Disease, PD) is a degenerative neurological disease that usually causes severe movement disorders such as tremor, muscle stiffness, and bradykinesia in patients. Its incidence rate is as high as 26% in the 60-year-old population, and will further increase with age, which has caused great negative impact on the patient's family and society. Deep Brain Stimulation (DBS) is currently an effective clinical method for the treatment of neurological diseases (such as Parkinson's, epilepsy, dystonia, etc.). It modulates the hypersynchronous neural network firing activities associated with neurological diseases by injecting high-frequency electrical pulses into the deep nuclei of the human brain. [0003] However, d...

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Problems solved by technology

[0003] However, due to the lack of real-time monitoring and analysis of the local field potential of the nervous system during DBS stimulation, the DBS strategies used in clinical practice all belong to the open-loop form, and the stimulation parameters can only rely on the experience of clinicians. Make parameter setting adjustments

Therefore, the current situation that DBS parameters cannot be adaptively adjusted according to the development of the patient's disease course and individual differences has always restricted the improvement of the efficacy of DBS, and even inappropriate DBS may induce gait instability, cognitive impairment, language impairment, and depression in patients. other serious side effects

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