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Furosemide micro-tablet and preparation method thereof

A technology of furosemide microtablets and microtablets, which is applied in the field of preparation of furosemide microtablets, can solve the problems of inability to meet the requirements of individualized medication, inability to conveniently and accurately divide doses, and inability to achieve precise drug administration, so as to ensure Effects of drug efficacy, reduction of adverse reactions, and ease of swallowing

Pending Publication Date: 2017-12-29
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When furosemide is used in children, its dose needs to be calculated according to the child’s kilogram body weight. Existing furosemide dosage forms cannot meet the requirements of individualized medication, and cannot be divided into doses conveniently and accurately, and precise drug administration cannot be achieved
In addition, when the existing pharmaceutical dosage form is taken, due to the excessive volume of the dosage form, the compliance of taking the medicine is poor for children, the elderly and patients who are inconvenient to swallow tablets.

Method used

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  • Furosemide micro-tablet and preparation method thereof
  • Furosemide micro-tablet and preparation method thereof
  • Furosemide micro-tablet and preparation method thereof

Examples

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Effect test

Embodiment 1

[0024] name

[0025] The preparation process is as follows: put furosemide, microcrystalline cellulose 102, lactose granulac200 and HPMC E3 in a multiphase mixer for uniform mixing, then add magnesium stearate and mix for 3 minutes, transfer the mixed material to high-speed rotary tabletting The tablet is compressed by the machine, and the finished tablet is obtained. The finished furosemide microtablets are obtained.

Embodiment 2

[0027]

[0028]

[0029] The preparation process is as follows: put furosemide, lactose granulac200 and HPMC E3 in the pot of the wet granulator, turn on the paddle for 10 minutes of initial mixing, after the mixing is completed, turn on the paddle and spray purified water for wet granulation; purified water Continue to granulate for 5 minutes after spraying; then wet granules obtained by wet granulation, and then placed in a fluidized bed for drying, after drying, the granules undergo dry granulation; the dry granules are evenly mixed with the prescribed amount of magnesium stearate Finally, the mixed material is transferred to a high-speed rotary tablet press for tablet compression to obtain the finished furosemide microtablet.

Embodiment 3

[0031]

[0032] Preparation process: After mixing furosemide, microcrystalline cellulose 102 and HPMC E3 evenly, the mixed material is added to a dry granulator to obtain suitable dry granules; after the granules are uniformly mixed with magnesium stearate, the mixed material is Transfer to a high-speed rotary tablet press for tablet compression to obtain finished tablets.

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Abstract

The invention discloses a furosemide micro-tablet preparation and a method for preparing the furosemide micro-tablet. The method comprises the following steps: taking furosemide, an adhesive, a diluent and other raw materials, performing top-spraying fluidized bed pelletization and other preparation methods, thereby obtaining the furosemide micro-tablet with excellent compressibility. The furosemide micro-tablet disclosed by the invention can be repeatedly administrated at a small dose, particularly for crowds with great individual metabolic differences, such as the old and infants, the administration can be counted so as to achieve accurate administration, and for crowds with difficulty of taking the conventional preparation, the compliance with medication can be improved. Moreover, the method and raw materials used in the invention are convenient for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a furosemide microtablet and provides a method for preparing the furosemide microtablet. Background technique [0002] Furosemide, also known as furosemide, furosemide, chemical name 2‐[(2‐furylmethyl)amino]‐5‐(sulfamoyl)‐4‐chlorobenzoic acid, is a powerful diuretic. Furosemide can inhibit renal tubular reabsorption and promote excretion of water, sodium, chloride, potassium, calcium, magnesium, phosphorus, etc. Furosemide can inhibit the activity of prostaglandin-decomposing enzymes, increase the content of prostaglandin E2, and thus have the effect of dilating blood vessels. Expand renal blood vessels, reduce renal vascular resistance, and increase renal blood flow, especially blood flow in the deep renal cortex. The diuretic effect is strong and rapid. Furosemide can dilate the pulmonary volume veins, reduce the permeability of pulmonary capi...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/341A61P7/10A61P9/04A61P13/12A61P25/00A61P9/12
CPCA61K9/2054A61K31/341
Inventor 谷雨田臧宪立
Owner 北京科信聚润医药科技有限公司
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