Macrocyclic lactam compound containing rigid biaryl skeleton, and preparation method thereof

A macrocyclic lactam and compound technology, applied in the field of macrocyclic lactam compounds, can solve the problems of long cycle, difficult chemical synthesis, complex structure, etc., and achieves the effects of mild process conditions, simple operation and cheap reagents
CN107540692AInactive Publication Date: 2018-01-05上海药明康德新药开发有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海药明康德新药开发有限公司
Publication Date
2018-01-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a macrocyclic lactam compound containing a rigid biaryl skeleton and a preparation method thereof, and mainly solves the technical problem that currently there are few macrocyclic lactam compounds containing a rigid biaryl skeleton linked by carbon-nitrogen bonds. The technical scheme of the present invention: the macrocyclic lactam compound containing rigid biaryl skeleton is characterized in that it has the following general structural formula: R1 and R2 are alkyl, cycloalkyl, aryl or alkyl are connected with heteroatom and aromatic One of the substituents of the group.
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Description

technical field

[0001] The invention relates to a macrocyclic lactam compound containing a rigid biaryl skeleton and a preparation method thereof. Background technique

[0002] Macrocyclic natural products usually have various biological activities and play an important role in the development of new drugs, especially in anti-infection, anti-cancer, and other therapeutic fields ( Molecules , 2013, 18 , 6230; J. Med. Chem. , 2014, 57 , 278). At present, there are a certain number of macrocyclic drugs on the market, mainly derived from natural products with complex structures. Cyclic peptides and macrolides are the two main classes. It is worth mentioning that macrocyclic antibiotics are the most successful class of macrocyclic drugs. Representative macrocyclic antibiotics include erythromycin, vancomycin, telavancin, daptomycin, rifampicin, spiramycin and so on. Followed by macrocyclic antineoplastic drugs, such as actinomycin D (dactinomycin), epothilone B, ixabepilo...

Claims

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