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Nitrite antidote as well as preparation method and application thereof

A technology of nitrite and antidote, applied in application, antidote, pharmaceutical formulation and other directions, can solve problems such as reducing animal body tolerance, prevent and alleviate sodium nitrite poisoning, reduce basal metabolism, and the preparation method is simple Effect

Inactive Publication Date: 2018-01-23
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The second object of the present invention is to provide a nitrite antidote to solve the technical problems of improving the basal metabolism of the animal body and reducing the tolerance of the animal body caused by nitrite poisoning in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of the present embodiment nitrite antidote comprises the following steps:

[0039] 1) Mix the sodium molybdate solution with a mass fraction of 1.5% and the copper sulfate solution with a mass fraction of 2%, and react at 60°C for 30 minutes after stirring evenly to obtain basic copper molybdate; wherein, the sodium molybdate solution and copper sulfate The mass ratio of the solution is 10:2;

[0040] 2) After fully washing the basic copper molybdate obtained in step 1), drying at 60° C., and then grinding into basic copper molybdate powder;

[0041] 3) Soak the basic copper molybdate powder obtained in step 2) in a zinc sulfate solution with a zinc concentration of 300mg / L, shake for 2 hours, then centrifuge and dehydrate at a low speed, dry at 60°C, and grind to obtain the final product; basic copper molybdate The mass ratio of powder to zinc sulfate solution is 1:1.

[0042] The nitrite antidote of this embodiment can be made into pills by fu...

Embodiment 2

[0045] The preparation method of the present embodiment nitrite antidote comprises the following steps:

[0046] 1) Mix the sodium molybdate solution with a mass fraction of 2% and the copper sulfate solution with a mass fraction of 3%, stir evenly, and react at 60° C. for 45 minutes to obtain basic copper molybdate; wherein, the sodium molybdate solution and the copper sulfate solution The mass ratio is 5:2;

[0047] 2) After fully washing the basic copper molybdate obtained in step 1), drying at 60° C., and then grinding into basic copper molybdate powder;

[0048] 3) Soak the basic copper molybdate powder obtained in step 2) in a zinc sulfate solution with a zinc concentration of 450mg / L, shake for 2 hours, then centrifuge and dehydrate at a low speed, dry at 60°C, and grind to obtain the final product; basic copper molybdate The mass ratio of powder to zinc sulfate solution is 1:20.

[0049] The nitrite antidote of this embodiment can be made into tablets by adding excip...

Embodiment 3

[0051] The preparation method of the present embodiment nitrite antidote comprises the following steps:

[0052] 1) Mix the sodium molybdate solution with a mass fraction of 9% and the copper sulfate solution with a mass fraction of 12%, stir evenly, and react at 60° C. for 35 minutes to obtain basic copper molybdate; wherein, the sodium molybdate solution and the copper sulfate solution The mass ratio is 2:2;

[0053] 2) After fully washing the basic copper molybdate obtained in step 1), drying at 60° C., and then grinding into basic copper molybdate powder;

[0054] 3) Soak the basic copper molybdate powder obtained in step 2) in a zinc sulfate solution with a zinc concentration of 960mg / L, vibrate for 2.5 hours, then centrifuge and dehydrate at a low speed, dry at 60°C, and grind to obtain the product; basic molybdate The mass ratio of copper powder to zinc sulfate solution is 1:15.

[0055] The nitrite antidote of this embodiment can be further added with excipient pecti...

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PUM

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Abstract

The invention relates to a nitrite antidote, in particular to the nitrite antidote as well as a preparation method and application thereof. The preparation method of the nitrite antidote comprises thefollowing steps: firstly, mixing molybdenum salt, copper salt and water, and carrying out a reaction to obtain basic copper molybdate; secondly, soaking the basic copper molybdate into a zinc salt solution and soaking for 1.5 to 2.5 hours, thus obtaining the nitrite antidote. The preparation method of the nitrite antidote, disclosed by the invention, has the advantages of simplicity, feasibilityand suitability for batch production; in addition, the nitrite antidote prepared according to the preparation method disclosed by the invention has a good detoxification effect on the nitrite.

Description

technical field [0001] The invention relates to a nitrite antidote, in particular to a nitrite antidote and a preparation method and application thereof. Background technique [0002] Nitrite is a chemical substance that widely exists in the natural environment, especially in food, such as grain, vegetables, meat and fish, all contain a certain amount of nitrite. [0003] A large number of studies have shown that due to the extensive use of nitrogen fertilizers in farmland and vegetable gardens, the content of nitrate nitrogen in the soil is generally high. Under the action of soil nitrifying bacteria, various forms of nitrogen in the soil are converted into NO 3- It is absorbed by food, vegetables, etc., and accumulates in plants. Excessive accumulation not only causes harm to the plants themselves or reduces their quality, but also is absorbed by animals and humans through the food chain, and is converted into nitrite in animals or humans. Potential harm to human body and...

Claims

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Application Information

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IPC IPC(8): A61K33/34A61K33/30A61K33/24A61P39/02A61P3/12A23K20/20
Inventor 杨自军李光照贺德良唐永坡张才汪纪仓王宏伟孔涛
Owner HENAN UNIV OF SCI & TECH
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