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Compound preparation for treating immunological rejection after organ transplantation and preparation method thereof

A compound preparation and immune rejection technology, which is applied in the field of compound preparation and its preparation for the treatment of immune rejection after organ transplantation, can solve the problems affecting the physical and mental health of patients with curative effects, and achieve the effect of avoiding gastrointestinal adverse reactions and weakening side effects

Inactive Publication Date: 2018-02-09
WUXI FORTUNE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the dosage forms of mycophenolate sodium on the market mainly include mycophenolate sodium enteric-coated tablets. For patients who take this drug for a long time, the probability of suffering from skin cancer, lymphoma and other lesions related to immunosuppression will increase significantly. Affect the efficacy and the physical and mental health of patients

Method used

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  • Compound preparation for treating immunological rejection after organ transplantation and preparation method thereof
  • Compound preparation for treating immunological rejection after organ transplantation and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] This example discloses the first specific implementation of a compound preparation for treating immune rejection after organ transplantation. The compound preparation is specifically a capsule, and its prescription is as follows:

[0028] Mycophenolate sodium 1500g, anhydrous lactose (filler) 352g, povidone K30 (binder) 220g, starch (diluent) 132g, cross-linked povidone (disintegrant) 352g, colloidal silicon dioxide (Glidant) 60g, magnesium stearate (lubricant) 30g, coating material 352g, salvia miltiorrhiza 440g, chuanxiong 350g, angelica 175g, astragalus 175g, tripterygium wilfordii 85g, safflower 85g.

[0029] A total of 10,000 capsules were made.

[0030] The preparation method of this compound preparation is as follows.

[0031] Pass the mycophenolate sodium, filler, disintegrant and other raw materials in the prescription quantity through a 100-mesh sieve, and set aside.

[0032] Step (1): After sieving mycophenolate sodium, filler, disintegrant, and diluent, p...

Embodiment 2

[0040] This example discloses the first specific implementation of a compound preparation for treating immune rejection after organ transplantation. The compound preparation is specifically a tablet, and its prescription is as follows:

[0041] Mycophenolate Sodium 1750g, Anhydrous Lactose 380g, Povidone K30 230g, Starch 134g, Crospovidone 346g, Colloidal Silicon Dioxide 65g, Magnesium Stearate 35g, Coating Material 360g, Salvia miltiorrhiza 400g, Chuanxiong 360g , Angelica 180g, Astragalus 180g, Tripterygium wilfordii 80g, safflower 80g.

[0042] A total of 10000 tablets were made.

[0043] The preparation method of this compound preparation is as follows.

[0044] Pass the mycophenolate sodium, filler, disintegrant and other raw materials in the prescription quantity through a 100-mesh sieve, and set aside.

[0045] Step (1): After sieving mycophenolate sodium, filler, disintegrant, and diluent, put them into a wet granulator for premixing, and add a prescribed amount of bi...

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Abstract

The invention provides a compound preparation for treating immunological rejection after organ transplantation and a preparation method thereof. The compound preparation comprises the following components in parts by weight: 25-35 parts of mycophenolate, 8-10 parts of red sage root, 6-8 parts of Ligusticum wallichii, 3-4 parts of Chinese angelica, 3-4 parts of radix astragali, 1-2 parts of thundergod vine, 1-2 parts of safflower, 6-8 parts of a filler, 3-5 parts of an adhesive, 6-8 parts of a disintegrating agent, 2-3 parts of a diluent, 1-2 parts of a flow aid, 0.5-1 part of a lubricant, and6-8 parts of an enteric coating material. The compound preparation is composed of the enteric delayed-release mycophenolate and a gastric-dissolved quick-release traditional Chinese medicine extractproduct, the compound preparation can avoid adverse reaction of gastrointestinal tract, and can obviously reduce the side effect due to long-term administration of mycophenolate in the compound preparation extracted through the traditional Chinese medicine extract product, so that the probability of skin cancer, lymph tumour and other immunosuppression-related pathology can be obviously reduced.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a compound preparation for treating immune rejection after organ transplantation and a preparation method thereof. Background technique [0002] With the improvement of medical technology, organ transplantation has developed to a certain extent as a way to treat a variety of terminal diseases, and it has brought some hope for the recovery of patients with advanced liver disease and renal insufficiency, but most of the organ transplants are xenotransplantation Therefore, adverse reactions such as postoperative immune rejection are common, leading to a series of postoperative syndromes such as low organ survival rate and other diseases, so postoperative drug treatment is particularly important. [0003] Among many immunosuppressants, mycophenolate mofetil (MMF) is a new type of anti-metabolism immunosuppressant, and its active ingredient mycophenolic acid (MPA) in the body inhibit...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P37/06A61K31/365
CPCA61K9/1652A61K31/365A61K36/232A61K36/236A61K36/286A61K36/37A61K36/481A61K36/537A61K2300/00
Inventor 李标有郁晨燕李晓明张峰韩小霜
Owner WUXI FORTUNE PHARMA
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