A kind of preparation method of d-dimer and fdp composite quality control product

A technique for dimers and quality control products, which is applied in the direction of analytical materials and instruments, can solve the problems of incomplete degradation of fibrin, lower quality of composite quality control products, and inactivation of fibrin, so as to avoid quality degradation and errors Small, high-purity effects
CN107677839BActive Publication Date: 2020-11-17北京众驰伟业科技发展有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
北京众驰伟业科技发展有限公司
Publication Date
2020-11-17

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Abstract

The invention discloses a D-dimer and a preparation method of an FDP composite quality control product. The preparation method comprises the following steps that 1, fresh blood is poured into a glasscontainer pre-containing glass beads and then is horizontally shaken; 2, white fibrinogen floating on the blood and obtained in the step 1 is re-dissolved; 3, the fibrinogen obtained in the step 2 issubjected to enzymolysis with protease to obtain the D-dimer and an FDP composite mother solution; 4, the composite mother solution obtained in the step 3 is diluted with protection liquid, so that the D-dimer and FDP in the composite mother solution reach target concentration, and the D-dimer and the FDP composite quality control product are obtained. The preparation method is simple in operationand accurate in concentration, large-scale production is facilitated, and the accurate and reliable quality control product is provided for clinical medical detection of D-dimer and the FDP.
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Description

technical field

[0001] The invention belongs to the technical field of in vitro diagnostic reagents, and relates to a preparation method of a composite quality control product of D-dimer and FDP. Background technique

[0002] In the hemagglutination test, it is often necessary to determine the content of D-dimer, fibrin and fibrinogen degradation products (Fibringen and Fibrin Degradation Products, FDP). With the development of technology, more and more blood coagulation tests are completed by automated blood coagulation analyzers. In order to monitor the operation of the instrument, quality controls of D-dimer and FDP are required.

[0003] Direct isolation of D-dimer or FDP from human plasma has limited sources and low yields. Quality control materials for D-dimer or FDP can be prepared from animal plasma to solve the source problem.

[0004] A single quality control product containing D-dimer or FDP is inconvenient to use, and the accuracy of the quality control product ...

Claims

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