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Polymer coating with antimicrobial material and method of making the same

An antimicrobial and antimicrobial agent technology, applied in the field of infection prevention coatings, antimicrobial agent coated medical devices, can solve problems such as significant cost

Active Publication Date: 2020-12-22
CARDIAC PACEMAKERS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cost of such an infection is not only significant in nature, but also in terms of the physical and emotional stress suffered by the patient

Method used

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  • Polymer coating with antimicrobial material and method of making the same
  • Polymer coating with antimicrobial material and method of making the same
  • Polymer coating with antimicrobial material and method of making the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Deposition of Parylene C and 100 nm Silver Nanoparticles

[0099]Silver nanoparticles of 100 nm diameter and Parylene C dimer powder (Specialty CoatingSystems company, SCS DPX-C) prepares the mixture. Approximately 0.10 to 0.15 milliliters (2 to 3 drops) of the silver nanoparticle dispersion was manually mixed with 1.5 grams of Parylene C dimer powder.

[0100] The mixture was placed in a removable boat and placed in a vacuum chamber to drive off any liquid. The mixture was then placed in the evaporator of the parylene deposition system. Air was evacuated from the deposition system including the evaporator, and the mixture was heated to 150 °C in the evaporator to sublime the dimer and silver nanoparticles. The sublimed dimer was then heated to 685 °C to pyrolyze the dimer before the pyrolyzed dimer (monomer) and silver nanoparticles were deposited on the substrate surface at room temperature to form an antimicrobial coating on the substrate .

[0101] image 3 ...

Embodiment 2

[0103] Deposition of Parylene C and 40 nm Silver Nanoparticles

[0104] Silver nanoparticles of 40 nm diameter and Parylene C dimer powder (Specialty CoatingSystems company, SCS DPX-C) prepares the mixture. Approximately 0.10 to 0.15 milliliters (2 to 3 drops) of the silver nanoparticle dispersion was manually mixed with 1.5 grams of Parylene C dimer powder.

[0105] The mixture was placed in a removable boat and placed in a vacuum chamber to drive off any liquid. The mixture was then placed in the evaporator of the parylene deposition system. Air was evacuated from the deposition system including the evaporator, and the mixture was heated to 150 °C in the evaporator to sublime the dimer and silver nanoparticles. The sublimed dimer was then heated to 685 °C to pyrolyze the dimer before the pyrolyzed dimer (monomer) and silver nanoparticles were deposited on the substrate surface at room temperature to form an antimicrobial coating on the substrate .

[0106] The antimic...

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Abstract

A method of preparing an antimicrobial coating on a surface. The method includes mixing parylene dimer and an antimicrobial agent to form a mixture, heating the mixture to sublimate the parylene dimer and suspending the antimicrobial agent within the sublimated parylene dimer, pyrolysis sublimation The parylene dimer to form the parylene monomer, while the antimicrobial agent is suspended in the parylene monomer, and the parylene monomer and antimicrobial agent are condensed together on the surface to polymerize Parylene monomers and form coatings containing parylene polymers and antimicrobial agents.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to Provisional Application No. 62 / 191,347, filed July 11, 2015, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention relates to the prevention of infections associated with medical devices. More specifically, the present invention relates to coatings and methods for coating medical devices with antimicrobial agents to prevent infection. Background technique [0004] Medical procedures and medical devices used in procedures may put patients at risk for nosocomial (eg, hospital-acquired) infections. For example, the average nosocomial infection rate associated with implanted pacemakers and implantable cardioverter-defibrillators is approximately 3%. In some cases of infection, the implantable medical device, including the device housing and any associated electrical leads or conduits, must be completely removed. After removal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/16A61L31/16
CPCA61L29/085A61L29/16A61L2300/102A61L2420/04A61L31/10A61L31/16A61L2300/104A61L2300/404A61L2420/02A61L2400/12C08L65/04A61L31/088C09D5/14A01N59/16A01N25/10A61L2420/06
Inventor 丹尼尔·弗兰克森玛丽·M·拜伦库尔特·G·库巴尔
Owner CARDIAC PACEMAKERS INC