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A kind of preparation method of polycaprolactone/bioceramic composite bone implant

A technology of polycaprolactone and bioceramics, applied in tissue regeneration, medical science, prosthesis, etc., to achieve the effect of improving mechanical properties

Active Publication Date: 2020-09-08
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to overcome the above-mentioned shortcoming of prior art, the object of the present invention is to provide a kind of preparation method of polycaprolactone / bioceramic composite bone implant, not only overcome the brittle problem of single ceramic implant, but also polycaprolactone composite Reinforced phases and ceramics enable gradient degradation in vivo

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  • A kind of preparation method of polycaprolactone/bioceramic composite bone implant
  • A kind of preparation method of polycaprolactone/bioceramic composite bone implant
  • A kind of preparation method of polycaprolactone/bioceramic composite bone implant

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preparation example Construction

[0028] A method for preparing a polycaprolactone / bioceramic composite bone implant, comprising the following steps:

[0029] 1) Firstly, according to the CT or MRI multi-planar reconstruction of the diseased tissue of the clinical patient, a 3D model whose structure matches the macrostructure is constructed through the Mimics software, and then the 3D model is imported into the 3D design software (Solidworks, Proe / Engineer) to complete a two-level 3D model design of disconnected porous structure bioceramic scaffolds: only one end surface of the II-level pipeline is connected to the outside world; the diameter of the I-level pipeline is 300-1500 μm; the diameter of the II-level pipeline is 500-1800 μm; %, II pipe porosity 5-60%, such as figure 1 shown;

[0030] 2) The additive manufacturing method is used to prepare the bioceramic scaffold blank with two levels of interconnected porous structure in step 1), and after high-temperature sintering, a high-strength bioceramic scaff...

Embodiment 1

[0036] Taking the preparation of a gradient-degradable polycaprolactone / β-tricalcium phosphate composite implant as an example, a method for preparing a polycaprolactone / bioceramic composite bone implant comprises the following steps:

[0037] 1) Firstly, according to the CT or MRI multi-planar reconstruction of the diseased tissue of the clinical patient, a three-dimensional model with a structure matching the macrostructure is constructed in the Mimics software, and then the model is imported into the three-dimensional design software Proe / Engineer to complete the porous structure with two levels of interconnection. Three-dimensional model design of structural bioceramic stents: only one end surface of the II-level pipeline is connected to the outside world, the diameter of the I-level pipeline is 800 μm, the diameter of the II-level pipeline is 1000 μm, the porosity of the I-level pipeline is 35%, and the porosity of the II-level pipeline is 20%;

[0038] 2) Using ceramic ligh...

Embodiment 2

[0044] Taking the preparation of gradient degradable polycaprolactone / β-tricalcium phosphate-hydroxyapatite ceramic composite implant as an example, the steps are as follows:

[0045] 1) Firstly, according to the CT or MRI multi-planar reconstruction of the diseased tissue of the clinical patient, a 3D model whose structure matches the macrostructure is constructed in the Mimics software, and then the 3D model is imported into the 3D design software Proe / Engineer to complete the two-level interconnected Three-dimensional model design of porous structure bioceramic scaffolds: only one end of the Class II pipe is connected to the outside world, the diameter of the Class I pipe is 300 μm, the diameter of the Class II pipe is 500 μm, the porosity of the Class I pipe is 30%, and the porosity of the Class II pipe is 25% ;

[0046] 2) Using ceramic light-curing technology to prepare the β-tricalcium phosphate-hydroxyapatite ceramic scaffold blank with two levels of interconnected por...

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Abstract

The invention relates to a preparation method of a polycaprolactone / biological ceramic composite bone implant. The preparation method comprises the following steps: firstly designing a three-dimensional model with two stages of porous structure biological ceramic supports which are not communicated each other, then preparing a green body with the two stages of porous structure biological ceramic supports which are not communicated each other, and carrying out high temperature calcining, so that a high-strength biological ceramic support is obtained; then preparing modified polycaprolactone reinforced particles, and preparing composite reinforced net premix liquid; finally putting the high-strength biological ceramic support into a container, burying with sodium chloride powder, only reserving the end face of a second stage pipeline communicated with the outside world, injecting the composite reinforced net premix liquid into the second stage pipeline of the high-strength biological ceramic support in a vacuumizing manner, and then heating and vacuumizing repeatedly for removing an organic solvent in the composite reinforced net premix liquid; and naturally cooling, so that the final gradient degradable polycaprolactone / biological ceramic composite bone implant is obtained. The preparation method provided by the invention has the advantages that mechanical properties of a composite scaffold can be integrally improved, and in vivo gradient degradation is realized.

Description

technical field [0001] The invention belongs to the field of biological tissue engineering, in particular to a method for preparing a polycaprolactone / biological ceramic composite bone implant. Background technique [0002] The repair and reconstruction of large bone defects caused by trauma, tumor, infection and abnormal development has always been a difficult problem in clinical medicine. Although bioceramics have high strength and can effectively induce new bone ingrowth at the initial stage of implantation, due to their high brittleness and poor bone conduction, the sudden collapse of their mechanical properties during the degradation process can easily lead to new bone fractures. Therefore, the use of biobrittle materials alone cannot actually achieve the continuous and reliable replacement of the strength and function of implants and new bone in the process of bone defect repair. Although polycaprolactone has high toughness and biocompatibility, it has low strength an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/18A61L27/12B33Y10/00B33Y70/10
CPCA61L27/12A61L27/18A61L27/50A61L27/58A61L2430/02B33Y10/00B33Y70/00C08L67/04
Inventor 刘亚雄伍言龙赵广宾陈旭陈若梦
Owner XI AN JIAOTONG UNIV
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