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Preparation method and use of conjugated microporous polymer with bacteriostatic activity

A technology with conjugated micropores and antibacterial activity, which can be used in botanical equipment and methods, applications, animal repellants, etc., and can solve problems such as operator hazards, limited application scope, and toxicity.

Inactive Publication Date: 2018-03-20
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among the traditional sterilants, chlorine gas, chlorine dioxide and ozone gas are the most effective bactericides, which can kill most microorganisms, but these gases are toxic at room temperature and have potential hazards to operators, which limits their use. Application range
Therefore, the research and development of high-efficiency water disinfectants is still a major challenge in the field of public health

Method used

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  • Preparation method and use of conjugated microporous polymer with bacteriostatic activity
  • Preparation method and use of conjugated microporous polymer with bacteriostatic activity
  • Preparation method and use of conjugated microporous polymer with bacteriostatic activity

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preparation example Construction

[0011] like figure 1 Shown, the preparation method of the conjugated microporous polymer with bacteriostatic activity of the present invention, its step is: according to 1,3-dibromo-5,5-dimethylhydantoin and 1,3,5 -Triethynylbenzene or 1,4-diethynylbenzene is mixed in a molar ratio of 1 to 10, with toluene and triethylamine as the solvent Pd(0) and CuI as the catalyst, and polymerized at 80°C for 72 hours to obtain a Bacterially active conjugated microporous polymers.

[0012] The use of the above-mentioned conjugated microporous polymer with antibacterial activity is to make a nanoporous foam, or to coat the surface of a porous substrate as an effective antibacterial agent in water.

[0013] The porous substrates mentioned above are filter paper, cloth, sponge.

[0014] The purposes of the above-mentioned conjugated microporous polymer with antibacterial activity, the dispersion concentration of the conjugated microporous polymer is 100 μg mL -1 The growth of Escherichia c...

Embodiment 1

[0015] Example 1: Weigh 1,3-dibromo-5,5-dimethylhydantoin (1.8472 g), 1,3,5-triethynylbenzene (0.6007 g), tetrakis(triphenylphosphine ) palladium (0) (100 mg), cuprous iodide (40 mg) in a 50 mL three-neck flask, N 2 Degas for 20 minutes; measure 7.5 mL each of toluene and triethylamine, N 2 Put it into the three-neck bottle under protection, and continue to pass N 2 10 minutes; after the degassing is completed, the temperature of the oil bath is slowly raised to 80 ° C, and the reaction is refluxed for 72 hours in the dark, such as figure 1 shown. After the reaction, the temperature of the reaction system was naturally cooled to room temperature, and the crude product was washed several times with chloroform, acetone, water, and methanol successively until the washing liquid was clear, and the washed product was extracted by Soxhlet with methanol for 72 hours; The product obtained after the extraction was placed in a blast drying oven at 70°C for 24 hours, and was named CMP...

Embodiment 2

[0019] Example 2: Weigh 1,3-dibromo-5,5-dimethylhydantoin (1.8472 g), 1,4-diethynylbenzene (0.7569 g), tetrakis(triphenylphosphine) palladium (0) (100 mg), cuprous iodide (40 mg) in a 50 mL three-necked bottle, N 2 Degas for 20 minutes; measure 7.5 mL each of toluene and triethylamine, N 2 Put it into the three-neck bottle under protection, and continue to pass N 2 10 minutes; after the degassing is completed, the temperature of the oil bath is slowly raised to 80 ° C, and the reaction is refluxed for 72 hours in the dark, such as figure 1 shown. After the reaction, the temperature of the reaction system was naturally cooled to room temperature, and the crude product was washed several times with chloroform, acetone, water, and methanol successively until the washing liquid was clear, and the washed product was extracted by Soxhlet with methanol for 72 hours; The product obtained after the extraction was placed in a blast drying oven at 70°C for 24 hours and named CMPH-2. ...

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Abstract

The invention relates to a preparation method and use of a conjugated microporous polymer with bacteriostatic activity. The method comprises the following steps: mixing 1, 3-dibromo-5, 5-dimethylhydantoin with 1, 3, 5-triethynylbenzene or 1, 4-diethynylbenzene according to a molar ratio of 1-10; carrying out polymerization for 72h at the temperature of 80 DEG C by taking methylbenzene and triethylamine as solvent and taking Pd(0) and CuI as catalysts so as to obtain the conjugated microporous polymer with the good bacteriostatic activity. The conjugated microporous polymer can be prepared intonano porous foam, or is used for coating the surface of a porous substrate, and is used as an effective antibacterial agent in water.

Description

technical field [0001] The invention relates to the preparation technology of antibacterial agent. Background technique [0002] Since the cooper research group first reported conjugated microporous polymers in 2007, conjugated microporous polymers CMPs (Conjugated Microporous Polymers) due to their high physical and chemical stability (insoluble in all organic solvents, thermal Gravimetric analysis (TGA) shows that the decomposition temperature of CMPs is greater than 300 °C), large BET specific surface area (so far the highest BET specific surface area is 6461 m 2 g -1 ). It has good application potential in many fields such as gas storage and conversion, catalysis, electrode materials, light harvesting, and supercapacitors. [0003] Among the traditional sterilants, chlorine gas, chlorine dioxide and ozone gas are the most effective bactericides, which can kill most microorganisms, but these gases are toxic at room temperature and have potential hazards to operators, ...

Claims

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Application Information

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IPC IPC(8): C08G73/06C09D179/04A01N35/02A01N43/50A01P1/00
CPCC08G73/0616A01N35/02A01N43/50C09D179/04
Inventor 李安陈丽华王菲孙寒雪朱照琪梁卫东
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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