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Compound nano graphene oxide drug carrier and preparation method thereof

A composite, nano-technology, applied in the directions of drug combinations, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., can solve the problems of large size of graphene oxide, difficult to control size uniformity, unable to meet the needs of tumor treatment, etc. Uniform size, simple preparation method, and the effect of overcoming bottlenecks

Active Publication Date: 2018-04-06
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the size of graphene oxide is generally large, and it is difficult to control its size uniformity
[0004] In addition, using graphene oxide as a drug carrier to simply load conventional chemotherapy drugs has been unable to meet the needs of tumor treatment.

Method used

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  • Compound nano graphene oxide drug carrier and preparation method thereof
  • Compound nano graphene oxide drug carrier and preparation method thereof
  • Compound nano graphene oxide drug carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Sonicate 0.5 mg / mL graphene oxide solution with an ultrasonic probe at 500W power for 4 hours to obtain a nano-graphene oxide solution with a particle size of 200nm; weigh 1mg wedelolactone and dissolve it in 10mL absolute ethanol, add 20μL Tween -80, sonicate in a 350W ultrasonic cleaner for 10 minutes to fully dissolve the wedelide to obtain a 0.1 mg / mL ethanol solution of wedelide;

[0024] The obtained nano-graphene oxide solution and wedelolide solution were mixed according to the volume ratio of 1:2, and ultrasonicated in a 350W ultrasonic cleaner for 50 minutes to fully mix the two solutions; Rotate and mix and incubate for 10 hours; then, use a rotary evaporator to evaporate the obtained solution for 20 minutes at 35°C and 70 rpm to remove ethanol in the system, and filter the obtained solution 3 times with a water-based filter membrane with a pore size of 0.22 μm to obtain Nano graphene oxide loaded with wedelolide;

[0025] Prepare an indocyanine green soluti...

Embodiment 2

[0029] Sonicate the 0.6mg / mL graphene oxide solution with an ultrasonic probe at 550W power for 4.5h to obtain a nano-graphene oxide solution with a particle size of 150nm; weigh 2mg of wedelolactone and dissolve it in 10mL of absolute ethanol, add 25μL Tween-80, sonicate in a 350W ultrasonic cleaner for 15 minutes to fully dissolve the wedelide to obtain a 0.2mg / mL ethanol solution of wedelide;

[0030] The obtained nano-graphene oxide solution and wedelolactone solution were mixed according to the volume ratio of 1:1, and ultrasonicated in a 350W ultrasonic cleaner for 60 minutes to fully mix the two solutions; Rotate and mix and incubate for 11 hours; then, use a rotary evaporator to evaporate the obtained solution for 25 minutes at 37°C and 75 rpm to remove ethanol in the system, and filter the obtained solution once with a water-based filter membrane with a pore size of 0.22 μm to obtain Nano graphene oxide loaded with wedelolide;

[0031] Prepare an indocyanine green so...

Embodiment 3

[0034] Sonicate 0.8 mg / mL graphene oxide solution with an ultrasonic probe at 600W power for 5 hours to obtain a nanometer graphene oxide solution with a particle size of 100nm; weigh 3mg wedelolactone and dissolve it in 10mL absolute ethanol, add 30μL Tween -80, sonicate in a 350W ultrasonic cleaner for 20 minutes to fully dissolve the wedelide to obtain a 0.3mg / mL ethanol solution of wedelide;

[0035] The obtained nano-graphene oxide solution and wedelolide solution were mixed according to the volume ratio of 2:1, and ultrasonicated in a 350W ultrasonic cleaner for 70 minutes to fully mix the two solutions; Rotate and mix and incubate for 12 hours; then, use a rotary evaporator to evaporate the obtained solution for 30 minutes at 38°C and 80 rpm to remove ethanol in the system, and filter the obtained solution twice with a water-based filter membrane with a pore size of 0.22 μm to obtain Nano graphene oxide loaded with wedelolide;

[0036] Prepare an indocyanine green solu...

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Abstract

The invention provides a compound nano graphene oxide drug carrier, which is the drug carrier is used for combining a natural anti-neoplastic extract wedelolactone and a photosensitizer indocyanine green to the surface of the nano graphene oxide through Phi-Phi stacking interaction. A preparation method of the compound nano graphene oxide drug carrier comprises the following steps: graphene oxideis processed through an ultrasonic method, the nano graphene oxide is obtained, the Phi-Phi stacking interaction is used, and wedelolactone and indocyanine green are loaded on the surface of the nanographene oxide in order. The preparation method is simple, the particle size of the nano graphene oxide is controlled at 100-200 nm, cycle time of the drug carrier in body can be prolonged, the compound nano graphene oxide drug carrier can absorb 600-900 nm near infrared, luminous energy is transformed to heat energy, photo-thermal treatment is realized, under irradiation of 808 nm near infrared,active oxygen is generated, and a purpose of photodynamic therapy is realized.

Description

technical field [0001] The invention belongs to the field of new materials, in particular to a graphene oxide drug carrier and a preparation method thereof. Background technique [0002] Graphene is a new type of two-dimensional nanomaterial with a nearly perfect single atomic layer structure discovered in 2004. Because of its good mechanical properties, thermal conductivity and high specific surface area, scientists generally believe that graphene is widely used in energy, information and biomedicine. And other fields have important reagent application prospects. Graphene oxide (GO) is a derivative of graphene. Its surface is rich in functional groups such as epoxy, carbonyl, hydroxyl, and carboxyl. The hydrogen and oxygen in the oxygen-containing functional groups will form hydrogen bonds with water molecules to further Increase the hydrophilicity of graphene oxide. In addition, the presence of oxygen-containing functional groups provides available active sites for attac...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K41/00A61K31/37A61P35/00
CPCA61K31/37A61K41/0052A61K41/0057A61K47/02
Inventor 高大威张旭武程欣
Owner YANSHAN UNIV
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