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Preparation method of drying type preparation for 3D printing artificial bone manufacturing

A 3D printing and drying technology, applied in the medical field, can solve the problems of unsuitable storage, single type of slow-release drugs, and inability to use multiple drugs in combination, achieving the effect of controllable dosage and easy storage.

Pending Publication Date: 2018-04-06
河北点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present application provides a method for manufacturing dry preparations by 3D printing artificial bone, which solves the problems in the prior art that the slow-release drugs currently used clinically are only a single type, and cannot be used in combination with multiple drugs, and are not suitable for storage. , to achieve the technical effect of taking it at any time, controlling the dosage, convenient and hygienic, and easy to store

Method used

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  • Preparation method of drying type preparation for 3D printing artificial bone manufacturing
  • Preparation method of drying type preparation for 3D printing artificial bone manufacturing
  • Preparation method of drying type preparation for 3D printing artificial bone manufacturing

Examples

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Embodiment 1

[0031] figure 1 It is a schematic flowchart of a manufacturing method of 3D printing artificial bone provided in the embodiment of the present application. Such as figure 1 As shown, the method includes:

[0032] Step 110: dissolving polylactic acid-glycolic acid copolymer with 1 weight percent in 1,4-dioxane into a solvent;

[0033] Step 120: Dissolving the first sensitive drug in the solvent to make a first suspension;

[0034] Specifically, the sensitive drug refers to the drug required for long-term sustained-release treatment of the target object during the treatment of osteomyelitis. Among them, according to the level of drug sensitivity, it can be divided into the first sensitive drug, the second sensitive drug, and the third sensitive drug, wherein, according to the degree of sensitivity to the target object, it can be defined as: the first sensitive drug The sensitivity is lower than the second sensitive drug, and the sensitivity of the second sensitive drug is lo...

Embodiment 2

[0048] In order to realize the use of more moderately sensitive drugs and further improve the sustained release effect, the embodiment of the present application also provides a method for manufacturing dry preparations by 3D printing artificial bones, such as figure 2 As shown, the method includes:

[0049] Step 210: adding the first paste material into a biological 3D printer for printing to form an inner layer;

[0050] Specifically, the first paste material that meets the input requirements of the biological 3D printer is added to the biological 3D printer for 3D printing. Since the 3D printing technology already belongs to the basic technology, the embodiment of the present application will not elaborate on the printing process and details of the 3D printer. method. It should be noted that the structure printed by the above 3D printer should match the bone defect required by the target object. That is to say, through the personalized characteristics of 3D printing techn...

Embodiment 3

[0065] In order to realize the use of more moderately sensitive drugs and further improve the sustained-release effect, the embodiment of this application also provides a method for manufacturing dry preparations with 3D printed artificial bones, please refer to image 3 , the method includes:

[0066] Step 310: dissolving the fifth sensitive drug in the solvent, and making a fifth suspension;

[0067] Step 320: After adding the first solid substance into the fifth suspension, add the calcium-containing compound with a weight percentage of 5%-50% to form a third solid substance.

[0068] Step 330: dissolving the sixth sensitive drug in the solvent, and making a sixth suspension;

[0069] Step 340: After adding the third solid substance into the sixth suspension, add the calcium-containing compound with a weight percentage of 5%-50% to form a fourth solid substance.

[0070] Step 350: After adding the fourth solid matter into the second suspension, add a calcium-containing co...

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Abstract

The invention provides a preparation method of a drying type preparation for 3D printing artificial bone manufacturing, and relates to the technical field of medicine. Copolymer with 0.1 to 20 wt% ofethyl lactate is dissolved by 1,4-dioxane to form a solvent; a first sensitive drug is dissolved in the solvent to form first turbid liquid; a first solid is prepared; then a second sensitive drug isdissolved to manufacture second turbid liquid; the first solid is added into second turbid liquid to prepare a first paste like material; the first paste like material is frozen and dried to form a granular first preparation intermediate product; and the first preparation intermediate product is split, filled, and sealed to form the drying type preparation. The drying type preparation solves the problems that in the prior art, in clinic, the sustained release drugs cannot be co-used with other drugs and are difficult to store. The provided drying type preparation can simultaneously carry different kinds of drugs, can be directly used, is convenient and hygiene, and is easy to store, and the using amount is controllable.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for manufacturing dry preparations by 3D printing artificial bones. Background technique [0002] Osteomyelitis is an infection and destruction of bone caused by aerobic or anaerobic bacteria, mycobacteria and fungi. In the treatment of osteomyelitis, it is often necessary to penetrate the bone injury site and fill it with bone cement and other substances. [0003] However, in the process of realizing the technical solution of the invention in the embodiment of the present application, the inventor of the present application found that the above-mentioned technology has at least the following technical problems: [0004] In the prior art, in the clinical treatment of osteomyelitis, bone cement is used as a carrier or support to use slow-release drugs, but the above-mentioned scheme cannot be used in combination with multiple drugs because the slow-release drugs current...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/44A61L27/58A61L27/54B33Y70/00
CPCA61L27/446A61L27/46A61L27/54A61L27/58A61L2300/604A61L2430/02B33Y70/00C08L67/04
Inventor 李征宇曾庆丰
Owner 河北点云生物科技有限公司
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