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Preparation method of herba epimedii extract and prepared extract

A technology of Epimedium extract and Epimedium, which is applied to medical preparations, pharmaceutical formulations, drug combinations and other directions containing active ingredients, can solve the problem that the extract has limited improvement effect on osteoporosis and poor osteoporosis relieving effect. Ideal, low content, etc.

Active Publication Date: 2018-04-10
JIANGSU KANION PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the content of flavonoids in Epimedium medicinal materials is low, even if the flavonoids are extracted, the effect of the obtained extract on relieving osteoporosis is not ideal, and because not all flavonoids are effective Osteoporosis can be improved. When the enrichment method is improper, the effect of the obtained extract on osteoporosis is also very limited.

Method used

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  • Preparation method of herba epimedii extract and prepared extract
  • Preparation method of herba epimedii extract and prepared extract
  • Preparation method of herba epimedii extract and prepared extract

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preparation example Construction

[0040] The present invention provides the preparation method of the epimedium extract and the obtained extract, and those skilled in the art can learn from the content of this article and appropriately improve the process parameters to realize it. What needs to be pointed out in particular is that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and relevant personnel can obviously make changes or appropriate changes and combinations to the method and application herein without departing from the content, spirit and scope of the present invention to realize and apply the present invention Invent technology.

[0041] The instruments that the present invention adopts are all common commercially available products, all can buy in the market.

Embodiment 1

[0044] Take Epimedium medicinal material, add 15-30 times the volume of the crude drug to decoct for 1-3 hours, filter, and use the filtrate for later use; add 15-30 times the volume of the dregs to decoct for 1-3 hours, filter, and the filtrate Reserve; add 15 to 30 times the volume of water to the dregs and decoct for 1 to 3 hours, filter, and set aside the filtrate;

[0045] Combine the filtrate obtained from the three extractions, concentrate under reduced pressure to a thick paste A with a relative density of d = 1.10-1.20 (50-60°C), let it cool (to room temperature), add raw medicinal materials and other quality water to the thick paste A to dissolve , stand at room temperature for about 4 to 6 hours, centrifuge, absorb the supernatant, pass through a D101 macroporous resin column (supernatant: resin = 1:2), and elute with distilled water (3 to 4 times the volume of the column bed) , the flow rate is 40ml / min, the water eluent is discarded, and then eluted with 85% ethan...

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Abstract

The invention relates to the technical field of traditional Chinese medicine extraction, and in particular relates to a preparation method of herba epimedii extract and the prepared extract. Accordingto the technical scheme, herba epimedii liquid obtained by water decoction extraction is subjected to separation and purification through macroporous adsorption resin and industrial chromatography (DAC250). The detection shows that the extract prepared by adopting the method contains 90-95 wt% of flavonoid compounds. The experiment shows that the extract can obviously improve the AKP and / or StrACP level, promote the calcium deposition, improve the bone density value, and increase the number of bone trabecula, therefore, the effect of improving osteoporosis is achieved, and the effect in improving osteoporosis of the extract provided by the invention is obviously superior to that of the herba epimedii extract prepared by adopting other methods, wherein P is smaller than 0.05.

Description

technical field [0001] The invention relates to the technical field of extraction of traditional Chinese medicines, in particular to a preparation method of an epimedium extract and the obtained extract. Background technique [0002] Osteoporosis (OP) is a systemic bone metabolic disease characterized by low bone mass and microarchitectural destruction of bone tissue, leading to increased bone fragility and susceptibility to fracture, usually due to metabolic imbalances in bone formation and bone resorption due to. According to statistics, there are more than 70 million patients with osteoporosis. WHO has listed osteoporosis, diabetes, and cardiovascular disease as the "three major killers" that endanger human health. Fractures caused by osteoporosis greatly increase the mortality rate. At present, there is no specific drug for the treatment of bone destruction-related diseases such as osteoporosis, and the commonly used bisphosphonates have problems such as many adverse re...

Claims

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Application Information

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IPC IPC(8): A61K36/296A61P19/10
CPCA61K36/296A61K2236/331A61K2236/39A61K2236/51A61K2236/55
Inventor 萧伟徐忠坤李芳秦建平殷洪梅顾少莉胡晗绯吴云王振中
Owner JIANGSU KANION PHARMA CO LTD
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