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Efficient membrane-dissolution crystallization method of double-unit coupling circulation

A technology of elution crystallization and high-efficiency film, which is applied in the directions of solution crystallization, crystallization separation, crystallization adjustment/control, etc., can solve the problems of increasing the industrialization cost of elution crystallization, reducing production efficiency, complicated equipment, etc., to simplify the coupling elution crystallization process, high production efficiency, and simple equipment

Inactive Publication Date: 2018-04-10
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional rectification and distillation process has its inherent limitations, and the equipment is complicated, consumes a lot of energy, and is not environmentally friendly, which increases the cost of industrialization of dissolution and crystallization as a whole and reduces production efficiency.

Method used

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  • Efficient membrane-dissolution crystallization method of double-unit coupling circulation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]Take the PES hollow fiber membrane to make the production membrane module, and the PVA flat membrane to make the pervaporation membrane module. Take 72g of NaCl and add it into deionized water to prepare a stable and uniform saturated solution at 25°C. Add the prepared crystallization solution into the raw material tank and keep it stable for 30 minutes. Add a sufficient amount of ethanol to the eluent storage tank, open the valve of the ethanol storage tank, adjust the peristaltic pump to 70rpm, and let the ethanol flow through the production membrane module. After the ethanol runs stably, open the valve of the raw material tank and adjust the peristaltic pump so that the flow rate of the NaCl solution is twice the flow rate of the ethanol. When the NaCl solution flows into the production membrane module, crystals are produced, and the mixed solution carrying the crystals passes through the filter device to produce solids. and the mother liquor, the solids pass through...

Embodiment 2

[0033] Take the PES flat membrane to make the production membrane module, and take the PHM hollow fiber membrane to make the pervaporation membrane module. Take 72g of NaCl and add it into deionized water to prepare a stable and uniform saturated solution at 25°C. Add the prepared crystallization solution into the raw material tank and keep it stable for 30 minutes. Add a sufficient amount of isopropanol to the solvent storage tank, open the valve of the isopropanol storage tank, and adjust the peristaltic pump to 10rpm, so that the isopropanol slowly flows through the production membrane module. After the operation of isopropanol is stable, open the valve of the raw material tank and adjust the peristaltic pump so that the flow rate of NaCl solution is 10 times higher than that of isopropanol. When the NaCl solution flows into the production membrane module, crystals are produced, and the mixed solution carrying crystals passes through the filter device The solid and mother l...

Embodiment 3

[0035] Take the PTFE hollow fiber membrane to make the production membrane module, take the PDMS flat membrane to make the pervaporation membrane module. Take 36g of acrylic resin and add it into acetone to prepare a stable and uniform saturated solution at 25°C. Add the prepared crystallization solution into the raw material tank and keep it stable for 30 minutes. Add a sufficient amount of water to the eluent storage tank, open the valve of the water storage tank, adjust the peristalsis to 70rpm, and let the water pass through the production membrane module. After the operation is stable, open the valve of the raw material tank and adjust the peristaltic pump so that the flow rate of the acrylic resin is 10 times higher than the water flow rate. The raw material solution flows into the production membrane module, and crystals are produced. The mixed solution carrying the crystals passes through the filter device to produce solids and The mother liquor and solids pass through...

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Abstract

The invention provides an efficient membrane-dissolution crystallization method of double-unit coupling circulation, and belongs to the technical field of crystallization engineering. When a raw material solution is added into a material solution tank and a dissolving agent is added into a storage tank, dissolving agent circulation is carried out until a system is stable; a peristaltic pump of theraw material tank is turned on, so that the dissolving agent fully contacts the raw material solution in a membrane assembly for generating a crystal product; and a mixed liquid carrying crystals flows into a filtering and drying device to form a solid and a mother liquor. The mother liquor passes through a pervaporation membrane assembly, and a pure solvent, a solute and a pure dissolving agentare separated out; the solvent and the solute are recycled; and the dissolving agent returns to the dissolving agent storage tank for secondary utilization. The addition amount of the dissolving agentand the pervaporation process are systematically regulated by controlling membranes and operation conditions, so that on the premise that the ideal crystal product is obtained, the efficiency, environment protection and greenness of the coupling process are further improved, the cost is reduced, and the recovery rate and yield of the crystal product are increased.

Description

technical field [0001] The invention belongs to the technical field of crystallization engineering, is particularly suitable for the continuous process of dissolution crystallization, and further improves the industrialization, high efficiency and environmental protection of dissolution crystallization. It has opened up a new path for the development of green crystallization industry. Background technique [0002] Elusion crystallization is a common separation method to produce crystals by adding a solvent to the solution to change the solubility of the solute in the original solvent. This process has unique advantages. Since there is no temperature change, it can be applied to the preparation of some special products. The application of dissolution crystallization in the pharmaceutical industry is becoming more and more extensive. With the development of science and technology, the coupling process of various technologies and dissolution and crystallization has also receiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D9/02B01D61/58
CPCB01D9/005B01D9/0059B01D9/0063B01D61/362B01D61/58B01D2009/0086B01D2311/25B01D2311/26
Inventor 姜晓滨脱凌晗贺高红肖武李祥村吴雪梅阮雪华焉晓明
Owner DALIAN UNIV OF TECH
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