Polyether sulfone/sulfonated polyether sulfone hollow fiber blend membrane for hematodialysis

A technology of sulfonated polyethersulfone and polyethersulfone, which is applied in dialysis system, semi-permeable membrane separation, membrane, etc., can solve the problems of small pore size, poor pressure tightness, decreased flux, etc., and achieve high ultrafiltration rate , excellent hydrophilicity and blood compatibility

Inactive Publication Date: 2018-04-13
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of cellulose membrane is its poor compactness. Under high pressure for a long time, the cellulose membrane is prone to creep, resulting in a smaller membrane pore size and an irreversible decrease in flux; and the disadvantage of polysulfone hollow fiber hemodialysis membrane Mainly due to poor blood compatibility, anticoagulants such as heparin need to be added in clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0019] Embodiment 1: Dry 20wt% polyethersulfone and 10wt% sulfonated polyethersulfone in a vacuum drying oven at 85°C for 15 hours, then move them into a spinning tank, and add spinning solvent dimethyl Acetamide 50wt% was dissolved at 60°C for 8 hours, then 20wt% polyethylene glycol 20000 was slowly added to the spinning tank, dissolved at 70°C for 6 hours, followed by static defoaming for 25 hours. By adjusting the pressure of the nitrogen cylinder to control the pressure of the spinning tank to 0.1Mpa, under the action of the pressure difference, the spinning stock solution enters the inserted tubular spinneret through the filter screen, and after a dry distance of 250mm, it enters the first spinning tank with a temperature of 45°C. A coagulation bath and a second coagulation bath with a temperature of 30° C. form a nascent film. The winding speed is 15m / min, the inner diameter of the prepared hollow fiber membrane is 0.28mm, the thickness of the fiber wall is 0.05mm, the i...

specific Embodiment approach 2

[0020] Embodiment 2: The difference between this embodiment and Embodiment 1 is that N-methyl-2-pyrrolidone is used as the spinning solvent. Other steps and parameters are the same as in the first embodiment. The inner diameter of the prepared hollow fiber membrane is 0.26mm, the fiber wall thickness is 0.05mm, the inner circle of the hollow fiber is round, the appearance is free of defects, and the pure water transmission rate is 45L / m 2 ·h·(0.1MPa), the cut-off rate of human serum albumin is 99.8%.

specific Embodiment approach 3

[0021] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the porogen uses a mixture of 15wt% polyethylene glycol 20000 and 5wt% polyvinylpyrrolidone, and the spinning solvent uses N-methyl-2- pyrrolidone. Other steps and parameters are the same as in the first embodiment. The inner diameter of the prepared hollow fiber membrane is 0.3mm, the fiber wall thickness is 0.06mm, the inner circle of the hollow fiber is round, the appearance is free of defects, and the pure water transmission rate is 35L / m 2 ·h·(0.1MPa), the cut-off rate of human serum albumin is 99.2%.

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Abstract

The invention relates to a polyether sulfone / sulfonated polyether sulfone hollow fiber blend membrane for hematodialysis. The blend membrane is prepared by spinning spinning solution containing sulfone / sulfonated polyether sulfone resin solid matter, spinning solvent, hydrophilia macromolecule and pore-foaming agent by dry-wet spinning technique. The flux of the blend membrane is greatly improved,and its hydrophilia and blood compatiability are also improved; besides, the polyether sulfone / sulfonated polyether sulfone hollow fiber blend membrane can be applied to be field of hematodialysis.

Description

technical field [0001] The invention relates to a polyethersulfone / sulfonated polyethersulfone hollow fiber blend membrane that can be used for hemodialysis and a manufacturing method thereof. Background technique [0002] Hemodialysis is based on the principle of Gibbs-Donman membrane balance to introduce the patient's blood and dialysate into the dialysis machine at the same time. When they flow through the two sides of the dialysis membrane respectively, the solute and water of the dialysis membrane move across the membrane to perform material exchange. way. In the 1960s, the first hollow fiber hemodialysis membrane was used clinically. For half a century, the research of hemodialysis membrane has also been paid attention to by people. In addition to good film-forming properties and mechanical strength, the membrane materials used for hemodialysis membranes are required to have better blood compatibility because the dialysis membranes are in direct contact with human bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/08B01D69/12B01D71/68B01D67/00A61M1/16
CPCA61M1/16B01D69/08B01D69/12B01D69/125B01D71/68B01D2325/02B01D2325/04
Inventor 王海涛师梦闪常娜侯亚杭
Owner TIANJIN POLYTECHNIC UNIV
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