A kind of synthetic method of 2-amino-4-acetamidoanisole

Abstract

The invention discloses a synthesis method of 2-amino-4-acetamino anisole. The synthesis method comprises the following steps: (1) carrying out a primary catalytic hydrogenation reduction reaction onp-nitroanisole and hydrogen in the presence of a catalyst A to obtain p-methoxyaniline; (2) carrying out an acetylation reaction on the p-methoxyaniline to obtain p-acetanisidine; (3) carrying out a nitration reaction on the p-acetanisidine to obtain 2-nitro-4-acetamino anisole; and (4) carrying out a secondary catalytic hydrogenation reduction reaction on the 2-nitro-4-acetamino anisole and hydrogen in the presence of a catalyst B to obtain 2-amino-4-acetamino anisole. 2-amino-4-acetamino anisole is synthesized by using a method sequentially comprising acylation, nitration and reduction, so that the problems that raw materials are easily oxidized, the amount of side reactions is large and a product is difficult to separate and low in purity in a traditional directional acylation process are avoided; and the purity of the product synthesized by using the method disclosed by the invention can reach 99.5%-99.8%.

Description

technical field [0001] The invention relates to a synthesis method of 2-amino-4-acetamidoanisole, which belongs to the field of organic chemical synthesis. Background technique [0002] 2-Amino-4-acetamidoanisole is an important intermediate for the preparation of C.I. Disperse Blue 79 and Disperse Violet 58 and other series of disperse dyes, especially the coupling component for the preparation of disperse dark blue H-GL with a large output. It is sold in domestic and foreign markets The demand is huge. The method of producing 2-amino-4-acetamidoanisole at home and abroad mainly contains following two kinds at present. [0003] The first preparation method is to use 2,4-dinitrochlorobenzene (or its intermediate product) as raw material to obtain 2-amino-4-acetamidoanisole through etherification, reduction and selective acylation. In this process route, iron powder, alkali sulfide or hydrazine hydrate was usually used in the reduction step before, which caused serious envi...

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Problems solved by technology

[0004] The second preparation method is to use 2-nitro-4-acetamidoanisole as a raw material to obtain 3-amino-4-alkoxyacetanilide through one-step catalytic hydrogenation. Although this method has a short route, the productive rate of the product is , high purity, but the cost of raw materials is greatly increased

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