Compound dura mater (spinal dura mater) implant as well as preparation method and application thereof

A composite implant technology, applied in the field of biomedicine, can solve the problems of immune rejection, infection, low mechanical properties, etc., and achieve the effects of preventing spillover, promoting regeneration, and promoting combination.

Active Publication Date: 2018-04-17
BEIJING BONSCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this xenogeneic material cannot be resorbed and thus may lead to complications such as infection and immune rejection
Degradable collagen matrix materials from bovine tendon also have certain problems, such as uncontrollable degradation rate, low mechanical properties, and the need to use sutures, etc.

Method used

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  • Compound dura mater (spinal dura mater) implant as well as preparation method and application thereof
  • Compound dura mater (spinal dura mater) implant as well as preparation method and application thereof
  • Compound dura mater (spinal dura mater) implant as well as preparation method and application thereof

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Experimental program
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Effect test

preparation example Construction

[0093] The preparation method of the composite dura (spinal) membrane implant has multiple embodiments, including tightly combining the first porous polymer layer with one side of the third polymer layer, and combining the second porous polymer layer with the first The other side of the three polymer layers is tightly bonded. The first porous polymer layer is on top of the implant and the second porous polymer layer is on the bottom of the implant.

[0094] The third polymer layer may be non-porous or its porosity sufficiently low to prevent cerebrospinal fluid spillage. The preparation method further includes impregnating the first porous polymer layer with an osteoconductive material, and impregnating the second porous polymer layer with a collagen material.

[0095] In some embodiments, heat pressing can be used in combination. For example, combining the first porous polymer layer with the third polymer layer includes heating the first porous polymer layer or the third po...

Embodiment 1

[0107] A composite dura (spine) membrane implant composed of three layers of polyetherketoneketone material: the surface of the polyetherketoneketone fabric of the first porous layer has a bone-like apatite coating with a porosity of 50% , thickness 2mm; the porosity of the polyether ketone ketone fabric in the middle layer is 0, and the thickness is 0.5 mm; the surface of the polyether ketone ketone fabric in the second porous layer has type I collagen coating, the porosity is 50%, and the thickness is 1 mm.

Embodiment 2

[0109] A composite dura (spine) membrane implant composed of three layers of ultra-high molecular weight polyethylene material: the first porous layer is DSM's The surface of the fabric is a bone-like apatite coating with a porosity of 60% and a thickness of 2mm; the middle layer is an ultra-high molecular weight polyethylene material with a porosity of 0.1% and a thickness of 0.5mm; the second porous layer is Fabric, the surface of which is coated with type I collagen, with a porosity of 60% and a thickness of 1.5mm.

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Abstract

The invention relates to a compound dura mater (spinal dura mater) implant which is used for repairing defected parts of implanted dura mater (spinal dura mater) and regenerating dura mater (spinal dura mater) tissue and a preparation method of the implant. A first porous layer of the implant promotes bone tissue formation as a bone conduction scaffold, a second porous layer promotes repairing andregeneration of dura mater (spinal dura mater) as a cell scaffold of regeneration collagen, and a middle layer prevents a cerebrospinal fluid from overflowing. The compound dura mater (spinal dura mater) implant can effectively promote regeneration of dura mater (spinal dura mater) and combination with bone.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a composite dura (spinal) implant for repairing or regenerating damaged dura (spinal) tissue in surgical operations. More precisely, the present invention relates to a composite dura (spinal) membrane implant made of porous material and its preparation method and application method. Background technique [0002] The human brain and spinal cord are covered by the dura mater (hereinafter referred to as the dura (spinal) mater), and its integrity is crucial to the normal work of the central nervous system. Such as figure 1 A schematic diagram of the structure of the human brain is shown. The dura mater (spinal) consists of three overlapping layers of tissue, from outside to inside: dura mater, arachnoid mater and pia mater. The dura (spinal) is the layer of hard membrane between the skull and the brain, and between the spine and the spinal cord. When the integrity of the human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/18A61L27/16A61L27/50A61L27/56A61F2/00
CPCA61L27/16A61L27/18A61L27/32A61L27/34A61L27/50A61L27/56A61F2/00A61F2/0077A61L2430/02C08L23/06C08L33/12C08L67/02C08L71/00
Inventor 聂洪涛张凯
Owner BEIJING BONSCI TECH CO LTD
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