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GLYCEROL PRODUCTION PROMOTER DERIVED FROM Staphylococcus Epidermidis, ANTIMICROBIAL PEPTIDE PRODUCTION PROMOTER DERIVED FROM SKIN EPIDERMAL KERATINOCYTES, AND UTILIZATION THEREOF IN EXTERNAL PREPARATION FOR SKIN PROTECTION

A technology of staphylococcus epidermidis and antimicrobial peptides, applied in skin care preparations, skin diseases, peptide/protein components, etc., can solve problems such as diarrhea and fermentation, achieve enhanced protection, sensory improvement, and inhibit the proliferation of bacteria Effect

Inactive Publication Date: 2018-04-17
ICHIMARU PHARCOS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, depending on individual constitutions, these methods sometimes lead to excessive intestinal fermentation and diarrhea

Method used

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  • GLYCEROL PRODUCTION PROMOTER DERIVED FROM Staphylococcus Epidermidis, ANTIMICROBIAL PEPTIDE PRODUCTION PROMOTER DERIVED FROM SKIN EPIDERMAL KERATINOCYTES, AND UTILIZATION THEREOF IN EXTERNAL PREPARATION FOR SKIN PROTECTION
  • GLYCEROL PRODUCTION PROMOTER DERIVED FROM Staphylococcus Epidermidis, ANTIMICROBIAL PEPTIDE PRODUCTION PROMOTER DERIVED FROM SKIN EPIDERMAL KERATINOCYTES, AND UTILIZATION THEREOF IN EXTERNAL PREPARATION FOR SKIN PROTECTION
  • GLYCEROL PRODUCTION PROMOTER DERIVED FROM Staphylococcus Epidermidis, ANTIMICROBIAL PEPTIDE PRODUCTION PROMOTER DERIVED FROM SKIN EPIDERMAL KERATINOCYTES, AND UTILIZATION THEREOF IN EXTERNAL PREPARATION FOR SKIN PROTECTION

Examples

Experimental program
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Embodiment

[0159] Examples are described in which Enterococcus faecalis EC-12, which is the most prominent among the target effects of the present invention, is used as a lactic acid bacterium of the genus Enterococcus, but the present invention is not limited to the following examples and the like.

[0160] (preservation of microorganisms)

[0161] On February 25, 2005 (the original deposit date), Enterococcus faecalis EC-12 was deposited in the National Institute of Advanced Industrial Science and Technology, the International Patent Biological Deposit Center (Central No. 1, East 1-chome, 1, Tsukuba, Ibaraki Prefecture, Japan, AIST ). The deposit number is FERM BP-10284.

[0162] According to a preferred embodiment of the present invention, the bacteria used as the active ingredient are bacteria belonging to the genus Enterococcus. More preferably the bacterium is Enterococcus faecalis.

[0163] Examples of Enterococcus faecalis include strains such as Enterococcus faecalis EC-12 (A...

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Abstract

Provided are: a skin-protecting agent and an external preparation for skin protection, which not only synergistically work in combination with a plant polysaccharide but also has an effect of promoting the production of glycerol derived from Staphylococcus epidermidis, which is a skin resident bacterium useful on the skin, and the production of antimicrobial peptides derived from skin epidermal keratinocytes and exhibits excellent effect of improving the touch feeling when applied to the skin. More specifically, the present invention provides a skin protective agent and an external preparationfor skin protection, which comprise a lactic acid bacterium belonging to the genus enterococcus.

Description

field of invention [0001] The present invention relates to a pharmaceutical and an external preparation for skin protection by promoting the production of glycerol derived from skin-resident bacteria, Staphylococcus epidermidis, which is a beneficial bacterium, and promoting antimicrobial peptides derived from skin epidermal keratinocytes One or a series of functions produced to protect the skin from external stressors such as dryness and harmful bacteria. Background technique [0002] On human skin, commensal microorganisms form a population as skin-resident flora. As skin-resident bacteria, Staphylococcus epidermidis, Staphylococcus aureus, corynebacteria bacteria, etc. reside on the skin, and the function of protecting the skin from external damage is maintained by the balance of these bacteria. However, it is known that the balance of these bacterial flora is due to exposure to environmental factors such as rapid temperature changes, drying or strong detergents or chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P1/04A61K8/99A61K35/744A61P17/16A61Q19/00
CPCA61K8/99A61K35/744A61K38/1729A61K2800/10A61P17/00A61P17/16A61P31/04A61Q17/005A61Q19/00A61K8/64
Inventor 高山和江牧冈祐子
Owner ICHIMARU PHARCOS CO LTD
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