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Granule for treating chronic gastritis and preparation method of granule

A technology of chronic gastritis and granules, which is applied in the field of chronic gastritis granules and its preparation, can solve the problems of inconsistency between severity and lesion severity, lack of specificity of symptoms, etc., and achieve the effect of rapid drug arrival at the disease site, fast absorption and improved curative effect

Inactive Publication Date: 2018-04-20
佛山市弘泰药物研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The clinical manifestations of different types of gastritis will be different, but the symptoms lack specificity, and the severity is often inconsistent with the severity of the lesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Take 9 grams of Evodia rutaecarpa, 9 grams of ginseng, 18 grams of ginger, and 4 grams of jujube, add 6 times the total amount of medicinal materials to decoct in water for 2 hours, then filter, take the filtered medicinal residues and add 8 times of water to decoct for 2 hour, filter, discard the medicinal residues, and combine two filtrates;

[0033] (2) Concentrate the combined filtrate to a relative density of 1.10-1.30 at 60-70°C, then cool to room temperature, add ethanol, stir while adding until the alcohol content is 50-60%, leave it for 12 hours, filter, Take the filtrate to recover ethanol until there is no alcohol smell, concentrate to obtain a thick paste with a relative density of 1.25-1.30 at 70-80°C;

[0034] (3) Take mannitol, microcrystalline cellulose and thick paste (thick paste: mannitol: microcrystalline cellulose = 1:0.3:0.15), mix well and then granulate, dry the granules at 50-60°C and then granulate to get the product .

Embodiment 2

[0036] (1) Take 10 grams of Evodia rutaecarpa, 9 grams of ginseng, 15 grams of ginger, and 5 grams of jujube, add 6 times the total amount of medicinal materials and decoct in water for 2 hours, then filter, take the filtered dregs and add 8 times of water to decoct 2 hours, filter, discard the dregs, and combine the two filtrates;

[0037] (2) Concentrate the combined filtrate to a relative density of 1.10-1.30 at 60-70°C, then cool to room temperature, add ethanol, stir while adding until the alcohol content is 50-60%, leave it for 12 hours, filter, Take the filtrate to recover ethanol until there is no alcohol smell, concentrate to obtain a thick paste with a relative density of 1.25-1.30 at 70-80°C;

[0038] (3) Take mannitol, microcrystalline cellulose and thick paste (thick paste: mannitol: microcrystalline cellulose = 1:0.3:0.15), mix well and then granulate, dry the granules at 50-60°C and then granulate to get the product .

Embodiment 3

[0040] (1) Take 10 grams of Evodia rutaecarpa, 10 grams of ginseng, 18 grams of ginger, and 6 grams of jujube, add 6 times the total amount of medicinal materials to decoct in water for 2 hours, then filter, take the filtered dregs and add 8 times of water to decoct 2 hours, filter, discard the dregs, and combine the two filtrates;

[0041] (2) Concentrate the combined filtrate to a relative density of 1.10-1.30 at 60-70°C, then cool to room temperature, add ethanol, stir while adding until the alcohol content is 50-60%, leave it for 12 hours, filter, Take the filtrate to recover ethanol until there is no alcohol smell, concentrate to obtain a thick paste with a relative density of 1.25-1.30 at 70-80°C;

[0042] (3) Take mannitol, microcrystalline cellulose and thick paste (thick paste: mannitol: microcrystalline cellulose = 1:0.3:0.15), mix well and then granulate, dry the granules at 50-60°C and then granulate to get the product .

[0043] The chronic gastritis granule of ...

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Abstract

The invention discloses a granule for treating chronic gastritis and a preparation method of the granule. The granule for treating the chronic gastritis is prepared from fructus evodiae, radix ginseng, rhizoma zingiberis recens and fructus jujubae. The granule for treating the chronic gastritis is prepared by taking common traditional Chinese medicinal materials as raw materials and are scientificin formula; by adopting a dosage form of granules, the granule has the characteristics that great dispersion and quick absorption are realized, the medicine quickly reaches lesions and curative effects are obviously improved; the granule can treat both symptoms and root causes and has safety in clinical application.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a chronic gastritis granule and a preparation method thereof. Background technique [0002] Gastritis is inflammation of the gastric mucosa caused by various reasons and is one of the most common digestive system diseases. According to the priority of clinical onset, it can generally be divided into two types: acute and chronic gastritis; according to different etiologies, it can be divided into Helicobacter pylori-associated gastritis, stress gastritis, autoimmune gastritis, etc. The pathological changes of gastritis caused by different etiologies are also different, usually including three processes, namely epithelial injury, mucosal inflammation and epithelial regeneration. Acute gastritis can be divided into simple, erosive and hemorrhagic, corrosive, suppurative gastritis according to its pathological changes, and chronic gastritis can be divided into t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61P1/04
CPCA61K36/754A61K9/1623A61K9/1652A61K36/258A61K36/725A61K36/9068A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 雷林芳
Owner 佛山市弘泰药物研发有限公司
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