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Method for detecting residual benzene in fluorouracil by means of gas chromatography

A technology of fluorouracil and gas chromatography, which is applied in the field of detection of benzene residues in fluorouracil by gas chromatography, can solve problems such as incomplete oral absorption, and achieve the effects of fast detection speed, convenient operation, and improved sensitivity

Inactive Publication Date: 2018-04-24
JINGHUA PHARMA GRP NANTONG
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Problems solved by technology

Fluorouracil is an anti-pyrimidine drug, which is clinically effective in the treatment of various tumors such as digestive tract tumors, breast cancer, ovarian cancer, choriocarcinoma, cervical cancer, bladder cancer, liver cancer, skin cancer, etc., especially for digestive tract cancer And other solid tumors have good curative effect, can be intravenous or intracavitary injection, oral absorption is not complete

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  • Method for detecting residual benzene in fluorouracil by means of gas chromatography
  • Method for detecting residual benzene in fluorouracil by means of gas chromatography
  • Method for detecting residual benzene in fluorouracil by means of gas chromatography

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Embodiment 1

[0060] A method for detecting benzene residues in fluorouracil by gas chromatography, characterized in that: comprising the following steps:

[0061] Step 1. Preparation of benzene standard solution: a. Weigh 0.05g of benzene and add it to a 100mL volumetric flask, dilute to volume with ethanol solution, then precisely draw 1.0mL in another 100mL volumetric flask, and dilute to volume with ethanol solution to obtain benzene Standard stock solution; b. Accurately draw 1.0mL benzene standard stock solution into a 25mL volumetric flask, and determine the solution with ethanol solution to obtain benzene standard solution;

[0062] Step 2. Preparation of the sample for the test solution: accurately weigh 1.0 g of the fluorouracil sample, place it in a 10 ml volumetric flask, and dilute the ethanol solution to obtain the test solution;

[0063] Step 3. Set the working conditions of the chromatograph: the chromatographic column is an HP-5 capillary chromatographic column, the size is...

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Abstract

The invention discloses a method for detecting residual benzene in fluorouracil by means of gas chromatography. The detection method comprises the following steps of preparation of a benzene standardsolution, preparation of a sample test solution, setting of working conditions of a chromatographic instrument, sample introduction detection and result calculation, and therefore the residual benzeneamount in fluorouracil is detected. The method has the advantages that the method for detecting the residual benzene amount in the fluorouracil by means of the gas chromatograph instrument is convenient, quick, accurate, stable and reliable, the quality of fluorouracil can be more comprehensively, objectively and scientifically evaluated, and the method has a great significance on the health of patients; the whole process is high in detection speed, convenient to operate and high in accuracy; by optimizing the chromatographic conditions for detection, the analysis time is greatly shortened, and the detection sensitivity is improved.

Description

technical field [0001] The invention belongs to the technical field of biochemical industry, and in particular relates to a method for detecting benzene residue in fluorouracil by gas chromatography. Background technique [0002] Fluorouracil (Fluorouracil, 5-FU), molecular formula C4H3FN2O2, molecular weight 130.08, is white or off-white crystal or crystalline powder. This product is slightly soluble in water, slightly soluble in ethanol, almost insoluble in chloroform, and soluble in dilute hydrochloric acid or sodium hydroxide solution. Fluorouracil is an anti-pyrimidine drug, which is clinically effective in the treatment of various tumors such as digestive tract tumors, breast cancer, ovarian cancer, choriocarcinoma, cervical cancer, bladder cancer, liver cancer, skin cancer, etc., especially for digestive tract cancer And other solid tumors have good curative effect, can be intravenous or intracavitary injection, oral absorption is not complete. [0003] At present, ...

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 吴玉祥许佳慧顾蓉蒋璐滕飞
Owner JINGHUA PHARMA GRP NANTONG
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