Antimicrobial peptide FR-31 and application thereof

Abstract

The solution discloses a short-chain polypeptide in the biotechnology field, antimicrobial peptide FR-31, the amino acid sequence of which is Phe-Arg-Ala-Ser-Gly-Gln-IIe-Thr-IIe-Thr-Val-Lys-Pro-Arg-Phe-Arg-Arg-IIe-Lys-Arg-Leu-Phe-Arg-Gly-Phe-Arg-Gly-Arg-Gln-Val-Leu. The antimicrobial peptide product disclosed by the invention does not cause hemolysis, the antimicrobial spectrum is broad, the antimicrobial peptide FR-31 has an excellent antimicrobial effect on both Gram-positive bacteria and Gram-negative bacteria as well as excellent inhibition effect on fungi. Therefore, the antimicrobial peptide FR-31 disclosed by the invention can be applied well in the preparation of medicines for resisting the infection of the Gram-positive bacteria or / and the Gram-negative bacteria or / and fungal diseases.

Description

technical field [0001] The invention relates to a short peptide in the field of biotechnology, in particular to an antibacterial peptide FR-31 and its application. Background technique [0002] Antimicrobial peptides (AMPs) are a class of small-molecule active peptides that are encoded by genes and synthesized by ribosomes when organisms defend against the invasion of external pathogens. They are important components of the innate defense system in organisms. As a kind of biologically active small molecules, AMPs generally have anti-bacteria, fungi, viruses, protozoa and other activities. In addition, AMPs can also be used as drug delivery carriers, antitumor agents, immune modulators, and signaling molecules. [0003] Antibiotics, as an important class of anti-infective drugs, are widely used in clinical, animal husbandry and aquaculture, etc. The country has begun to seek alternatives to antibiotics, and AMPs have become one of the most potential alternatives to antibiot...

AI Technical Summary

Problems solved by technology

Quite a few natural antibacterial peptides have low antibacterial activity, poor stability, high toxicity, or cause hemolysis of eukaryotic cells; in addition, some AMPs have poor inhibitory effect on drug-resistant bacteria, which cannot meet the requirements of practical applications; By modifying natural AMPs or synthesizing brand-new artificial AMPs through rational design, some or even all of the above shortcomings can be improved to a large extent to meet different application requirements.

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