Composite porous scaffold loaded with drug-loaded microspheres and its preparation method and application
A technology of porous stents and drug-loaded microspheres, which is applied in the fields of pharmaceutical formulation, pharmaceutical science, and drug delivery, can solve the problems of limited drug loading mode and weak sustained release function, and achieve the effect of expanding the drug release function.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0030] Another aspect of the present invention provides a method for preparing a composite porous scaffold loaded with drug-loaded microspheres, the method comprising the steps of:
[0031] (1) Prepare the 3D printing slurry, the 3D printing slurry can be any suitable slurry suitable for 3D printing, preferably, for example, the 3D printing slurry can be an inorganic powder material suitable for 3D printing The slurry, such as hydroxyapatite slurry, calcium phosphate slurry, biphasic calcium phosphate slurry, bioglass slurry, etc. More specifically, for example, a homogeneous slurry can be obtained by gradually adding hydroxyapatite powder into polyvinyl alcohol and mixing with a high-speed homogenizer. In use, prior to 3D printing, air bubbles in the slurry can be removed by, for example, ultrasonic and vacuum treatment.
[0032] (2) Loading the 3D printing paste into the cylinder of the 3D device, and printing a first module with grooves and a second module with protrusions...
Embodiment 1
[0038] Example 1: Preparation of composite porous scaffold-1 loaded with drug-loaded microspheres
[0039] First prepare the aqueous solution (16%, w / v) of polyvinyl alcohol, wherein w refers to the quality (unit: g) of polyvinyl alcohol used here of solute, v is the volume (unit: ml) of solvent water used. Weigh the hydroxyapatite powder (15g), gradually add it into the polyvinyl alcohol solution (10ml), and use a high-speed homogenizer (6000rpm) to mix the materials (15min) to obtain a uniform slurry. The slurry was defoamed by sonication and vacuum. Afterwards, install the obtained hydroxyapatite slurry on the printing equipment, design the printing programs of the first module and the second module respectively, and after setting the parameters, print the first and second modules (air pressure 0.5MPa, layer height 0.3mm, fiber spacing 0.83mm). Among them, the geometric parameters of the first module (length*width*height): 15mm*15mm*10mm, the groove parameters (length*wid...
Embodiment 2
[0042] Example 2: Preparation of composite porous scaffold-2 loaded with drug-loaded microspheres
[0043] An aqueous solution of polyvinyl alcohol (16%, w / v) was first prepared. Weigh the hydroxyapatite powder (15g), gradually add it into the polyvinyl alcohol solution (10ml), and use a high-speed homogenizer (6000rpm) to mix the materials (15min) to obtain a uniform slurry. The slurry was defoamed by sonication and vacuum. Afterwards, install the obtained hydroxyapatite slurry on the printing equipment, design the printing programs of the first module and the second module respectively, and after setting the parameters, print the first and second modules (air pressure 0.5MPa, layer height 0.3mm, fiber spacing 0.93mm). Among them, the geometric parameters of the first module (length*width*height): 15mm*15mm*10mm, the groove parameters (length*width*height): 7mm*7mm*5mm; the geometric parameters of the second module (length*width*height) : 15mm*15mm*3mm, raised parameters (...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More