A preparation method of anti-oxidation nanofiber electrospun membrane medical dressing
A nanofiber, electrospun membrane technology, applied in the field of medical dressings, can solve the problems of poor biocompatibility of dressings, poor drug action effect, short drug action time, etc., achieves high comfort, is not easy to inflammatory reaction, prevents oxygen free Radical and various cytotoxic damage effects
Active Publication Date: 2021-03-12
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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[0003] According to the deficiencies of the prior art, the present invention provides a method for preparing an anti-oxidation nanofiber electrospun membrane medical dressing, and the anti-oxidation nanofiber electrospun membrane material medical dressing prepared by the method can solve the drug effect of current medical dressings. Short time, poor drug effect, poor biocompatibility of the dressing itself, no degradability and other problems
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[0029] The present invention will be further described below in conjunction with the embodiments and accompanying drawings. Its concrete example is as follows:
[0030] (1) Trichloromethane (chloroform) and dimethyl carbamoyl are configured as a solvent at a ratio of 9:1, and PCL (Polycaprolactone, polycaprolactone) particles are dissolved in this solvent as a solute, and the mass fraction is configured as 22% PCL solution;
[0031] (2) Electrospinning the prepared polycaprolactone (PCL) solution (specific parameters: flow rate: 1.3μl / min, voltage 6-7kV, distance 15cm) to obtain PCL nanofiber electrospun membrane, which is dried in vacuum After treatment, the PCL electrospun membrane was irradiated with ultraviolet light for 2 hours, soaked in 75% alcohol for 2 hours, and finally washed with PBS solution for 5-6 times to cut the PCL electrospun membrane into 3cm*3cm membranes. Packed in sterile dry containers;
[0032] (3) Take the collagen powder, add it to the acetic acid...
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The invention provides a method for preparing an anti-oxidation nanofiber electrospun membrane medical dressing. The specific preparation of the medical dressing is as follows: chloroform and dimethylcarbamyl are mixed to form a mixed solvent, and PCL particles are dissolved in the above mixed solvent to form a PCL solution, and then electrospinning is performed to obtain PCL nanofiber electrospinning. Spinning membrane; take collagen powder and add it to acetic acid solution to make colloidal homogeneous solution A, take Nac and dissolve it in deionized water to get solution B, and mix solution A and solution B with ultrasound to make it is loaded with antioxidant The collagen solution of the drug Nac is centrifuged to remove air bubbles, and then evenly added to the PCL nanofiber electrospun membrane with a sample gun, and then freeze-dried, soaked in a cross-linking agent solution, and freeze-dried to obtain the medical dressing. The PCL nanofiber electrospun membrane prepared by the invention has the ability to promote wound healing, and the collagen loaded with Nac drug is used as an antioxidant drug, which helps to strengthen the healing effect of the PCL membrane.
Description
technical field [0001] The invention provides a medical dressing, specifically a method for preparing an anti-oxidation nanofiber electrospun membrane medical dressing. Background technique [0002] Difficulty in wound healing is a frequently encountered problem in plastic surgery. Clinically, the treatment of small wounds is mainly through active iodine disinfection, spraying human epidermal growth factor and other drugs, and finally covering with sterile gauze. For large wounds, skin grafts and skin flaps are mainly used. After surgical treatment, the surface is covered with Vaseline gauze, and finally covered with sterile gauze. Although the above treatment methods are relatively mature, there are still the following deficiencies: (1) it is difficult for the drug to maintain an effective concentration in the wound for a long time, and it cannot stably and continuously exert the drug effect; Degradability, need to be replaced every 3 days. Contents of the invention ...
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IPC IPC(8): A61L15/26A61L15/32A61L15/44A61L15/42A61L15/40D06M15/15D06M13/352D06M13/328D04H1/728D06M101/32
CPCA61L15/26A61L15/325A61L15/40A61L15/425A61L15/44A61L2300/214A61L2300/412A61L2300/602D04H1/728D06M13/328D06M13/352D06M15/15D06M2101/32C08L67/04C08L89/00
Inventor 侯金飞孙家明汪振星周牧冉吴顺陈雳风李嘉伦周楚超刘绍恺曾宇阳牟珊黎媛罗超方慧敏
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV