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Production process for preventing enramycin product degradation

A production process, the technology of enramycin, is applied in the field of production process to prevent the degradation of enramycin products, which can solve the problems of high degradation rate, achieve the effects of reducing the degree of degradation, inhibiting the reaction of alcohol hydroxyl groups, and protecting against degradation

Inactive Publication Date: 2018-05-22
SHANXI XINYUAN HUAKANG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore the present invention proposes a kind of production technology that prevents enramycin product from degrading, is used to solve the problem that the degradation rate of enramycin product in the existing industry is higher in storage and transportation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Adjust the pH of the fermentation broth to 4.5-5.6 with phosphoric acid, increase the temperature of the fermentation broth to 60°C for cooling, and then reduce the temperature to 35°C to 40°C, then add 0.8% sodium phosphate to the fermentation broth and keep it warm for 30 minutes Finally, the temperature is raised to 60℃, and then the plate and frame filtration with a pressure of 0.52~0.68MPa is carried out, and the filter pressure time is 1h → the mycelium is crushed to 80~90 meshes → the inlet temperature is 90~110℃, and the outlet temperature is 70~ Flash drying at 90°C;

[0024] The flash-dried fermentation broth enters the pre-mixing process. The pre-mixing process is to take an appropriate amount of powdered mycelium, add 0.5% by mass sucrose ester to the powdered mycelium, stir evenly, and add 0.6% by mass talcum powder And rice husk powder with a quality of 2%, and finally the enramycin product is obtained, and the storage stability of the product is improved by ...

Embodiment 2

[0026] Adjust the pH of the fermentation broth to 4.8-5.0 with dilute sulfuric acid, heat the fermentation broth to 60°C for 30 minutes, perform a cooling treatment, and reduce the temperature to 35°C to 40°C, then add 1% sodium sulfite to the fermentation broth , Heat preservation for 30 minutes, and finally heat up to 60℃, and then carry out plate and frame filtration with a pressure of 0.52~0.68MPa. The filter press time is 2h→crush the mycelium to 80~90 mesh→inlet temperature 90~110℃, Flash drying with wind temperature of 70~90℃;

[0027] The flash-dried fermentation broth enters the pre-mixing process. The pre-mixing process is to take an appropriate amount of powdered mycelium, add 1% mass of sucrose ester to the powdered mycelium, stir evenly, and add 1% mass of talcum powder And rice husk powder with a quality of 5%, and finally the finished product of enramycin is obtained, and the storage stability of the finished product is improved by 18.4%.

Embodiment 3

[0029] Adjust the pH of the fermentation broth to 4.8-5.0 with dilute sulfuric acid, heat the fermentation broth to 60°C for 30 minutes, perform a cooling treatment, and reduce the temperature to 35°C to 40°C, and then add 0.5% sodium sulfite to the fermentation broth. , Heat preservation for 30 minutes, and finally heat up to 60℃, and then carry out plate and frame filtration with a pressure of 0.52~0.68MPa. The filter press time is 1.5h → crush the mycelium to 80~90 mesh → inlet temperature 90~110℃, Flash drying with outlet temperature of 70~90℃;

[0030] The flash-dried fermentation broth enters the pre-mixing process. The pre-mixing process is to take an appropriate amount of powdered mycelium, add 1% mass of sucrose ester to the powdered mycelium, stir evenly, and add 0.5% mass of talcum powder And rice husk powder with a quality of 3%, and finally the enramycin product is obtained, and the storage stability of the product is improved by 15.6%.

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PUM

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Abstract

The invention relates to the technical field of biological veterinary medicine, in particular to a production process for preventing enramycin product degradation. The process comprises the steps of fermentation liquid preparation, plate frame filtering, mycelium crushing, flashing drying and finished product obtaining. Before the fermentation liquid is subjected to plate frame filtering, the temperature of the fermentation liquid is raised to 60 DEG C; heat insulation is performed for 30 minutes; temperature lowering treatment is performed; the temperature is lowered to 35 to 40 DEG C; then,sodium sulfite is added into the fermentation liquid; heat insulation is performed for 30 minutes; finally, the temperature is raised to 60 DEG C; the fermentation liquid subjected to flashing dryingis subjected to premixing treatment; in the premixing process, a proper amount of powder mycelia is taken; sucrose ester is added into the powder mycelia; uniform stirring is performed; auxiliary materials are added; the auxiliary materials are prepared from talcum powder and rice hull powder; finally, a finished product is generated. The production process has the advantages that simplicity is realized; the implementation is easy; the cost is low; the enramycin degradation degree obtained by the pretreated fermentation liquid is obviously reduced; the stability of the obtained enramycin pre-mixing agent finished product in the storage process is obviously improved; great convenience and high stability are realized in the storage, transportation and application process.

Description

Technical field [0001] The present invention relates to the technical field of biological veterinary drugs, and in particular to a production process for preventing the degradation of enramycin products. Background technique [0002] Enramycin is a polypeptide antibiotic, and its antibacterial mechanism is to inhibit the synthesis of bacterial cell walls. Enramycin has a strong activity against Gram-positive bacteria, especially against harmful Clostridium bacteria in the intestine. Enramycin can also change the balance of the intestinal flora by inhibiting the growth and reproduction of harmful bacteria in the intestine, and increase the absorption and utilization of nutrients in the feed. With long-term use of enramycin, bacteria are not easy to develop resistance to it, and there is no obvious cross-resistance between enramycin and other antibiotics. [0003] However, the degradation of the product during storage and transportation, the pressure on the production cost of the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08C07K1/34
CPCC07K7/08
Inventor 马爱明
Owner SHANXI XINYUAN HUAKANG CHEM