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Degradable luminal stent with thermal adhesive composite structure, and preparation method thereof and application thereof

A composite structure and thermal bonding technology, applied in stents, medical science, surgery, etc., can solve the problems of stent structural integrity damage, uneven material degradation, stent collapse, etc., and achieve poor mechanical properties and bond fastness Large, the effect of improving the radial support force

Active Publication Date: 2018-05-25
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradable scaffolds prepared by these methods will all degrade in the early stage. The molecular chains of the fast-degrading components inside the material break first, resulting in uneven degradation of the material, and the structural integrity of the scaffold is quickly destroyed, resulting in the overall collapse and failure of the scaffold.

Method used

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  • Degradable luminal stent with thermal adhesive composite structure, and preparation method thereof and application thereof
  • Degradable luminal stent with thermal adhesive composite structure, and preparation method thereof and application thereof
  • Degradable luminal stent with thermal adhesive composite structure, and preparation method thereof and application thereof

Examples

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Embodiment 1

[0036] A method for preparing a degradable luminal stent with a thermally bonded composite structure:

[0037] Step 1: Such as figure 1 As shown, polycaprolactone (PCL) is used as the shell yarn 2 to make four sets of bobbins 3 and placed on the yarn carrier 4 of the knitting machine; the yarn carrier 4 drives the bobbin 3 carried by the yarn carrier 4 to perform the knitting action . The yarn tube 3 carrying the PCL moves in the opposite direction around the poly-p-dioxanone (PPDO) core yarn 5 drawn from the central through hole of the braiding machine track disk to form a braided yarn 1 with a shell core structure. The PCL shell yarn is a multifilament with a diameter of 0.10mm, and the PPDO core yarn is a monofilament with a diameter of 0.30mm. The weaving method used is 8 spindles diamond weaving;

[0038] Step 2: Such as figure 2 As shown, 4 groups of knitting yarns 1 and 20 groups of single-component degradable polymer yarns 7 of PPDO monofilament are made into bobbins 3 an...

Embodiment 2

[0041] A method for preparing a degradable luminal stent with a thermally bonded composite structure:

[0042] Step 1: Such as figure 1 As shown, PLLA is used as the shell yarn 2 to make 8 sets of yarn tubes 3 and placed on the yarn carrier 4 of the knitting machine; the yarn carrier 4 drives the yarn tube 3 carried by the yarn carrier 4 to perform the knitting action. The bobbin 3 carrying PLLA moves in the opposite direction around the polyglycolide (PGA) core yarn 5 drawn from the central through hole of the orbit disk of the braiding machine, so that the twist direction of the shell yarn 2 is positive and antisymmetric with the core yarn 5 as the central axis. , The braided yarn 1 that forms the shell core structure, the PLLA shell yarn 2 is a multifilament with a diameter of 0.05mm, and the PGA core yarn 5 is a monofilament with a diameter of 0.25mm. The weaving method used is 8 spindles regular weaving;

[0043] Step 2: Such as figure 2 As shown, 8 groups of knitting yarns 1...

Embodiment 3

[0046] A method for preparing a degradable luminal stent with a thermally bonded composite structure:

[0047] Step 1: Such as figure 1 As shown, polyglycolide-lactide (PLGA) is used as the shell yarn 2 to make 4 sets of bobbins 3 and placed on the yarn carrier 4 of the knitting machine; the yarn carrier 4 drives the bobbin carried by it to move Implement the knitting action. The bobbins 3 carrying PLGA are equally divided into two groups, around a group of polyglycolide (PGA) core yarns 5 drawn out from the central through hole of the braiding machine track disk to do a reverse movement, so that the twist direction of the shell yarn 2 is centered Yarn 5 is a braided yarn 1 whose central axis is positively and antisymmetrically staggered to form a shell core structure. PLGA shell yarn 2 is a multifilament with a diameter of 0.08mm. PGA core yarn 5 is a monofilament with a diameter of 0.20mm. The weaving method used is 8 Ingot diamond weaving;

[0048] Step 2: Such as figure 2 As...

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Abstract

The invention discloses a degradable luminal stent with a thermal adhesive composite structure, and a preparation method thereof and application thereof as a mechanically expanded implantable woven stent against stenotic disease. The stent is made of a hollow tubular stent preforming body composed of woven yarn and degradable macromolecular silk yarn through a heat treatment process, shell yarn ismolten in the braided yarn, fusion flowing occurs at interweaving points of two groups of woven yarn, the interweaving points are bonded, and non-interweaving points of the woven yarn form the complete coating for core yarn through softening, fusion and viscose flow. The preparation method includes the steps of making the shell yarn and the core yarn into the woven yarn which is of a shell core structure, the woven yarn and the degradable macromolecular silk yarn are made into the tubular stent preforming body; and after undergoing heat treatment, the tubular stent preforming body forms the degradable luminal stent with the thermal adhesive composite structure. According to the degradable luminal stent, the interweaving points of the stent are regularly bonded and woven, so that the slippage of the interweaving points is limited, the number of the interweaving points in unit length is kept when the stent is subjected to the effect of a radial external force, and thus the radial support force of the stent is improved.

Description

Technical field [0001] The invention relates to a degradable lumen stent with a thermal bonding composite structure and a preparation method thereof, and belongs to the technical field of braided self-expanding lumen stents. Background technique [0002] Biodegradable stents are another revolutionary advance in the treatment of human luminal stenosis diseases following bare metal stents and drug-eluting stents. It is a type that provides effective support for the lumen during the repair period of the disease, and automatically degrades or is absorbed after the lumen is healed, and will not cause permanent damage to the human body. The ideal degradable stent can provide temporary wall support to promote the physiological repair of the damaged part, thereby preventing re-narrowing, and will not limit surgery or secondary interventional treatment. Due to the small inflammatory response and controllable degradation time, degradable polymer materials are currently the preferred mater...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L31/14A61L31/06
Inventor 王富军赵帆王璐刘来俊薛雯
Owner DONGHUA UNIV
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