Preparation method of freeze-drying excipient

Abstract

The invention relates to a preparation method of a freeze-drying excipient, and particularly relates to the preparation method of the freeze-drying excipient which facilitates breaking away from the forming mould after freeze-drying by surface treatment of a forming mould.

Description

technical field [0001] The invention relates to a preparation method of a freeze-dried excipient preparation, in particular to a preparation method of a freeze-dried excipient preparation which facilitates separation from the molding mold after freeze-drying through surface treatment of a molding die. Background technique [0002] Freeze-drying excipient technology refers to adding a skeleton support agent and a binder to a flowable liquid, semi-solid or solid active ingredient, or the flowable liquid, semi-solid or solid itself contains a binder and a skeleton The support agent is then poured into a molding mold and shaped by a freeze-drying process. The preparation prepared by the freeze-drying excipient technology is called a freeze-dried excipient preparation. [0003] Because this type of preparation adopts a freeze-drying process, which can protect heat-sensitive components from being destroyed, and at the same time produce a large number of micropores and channels thr...

AI Technical Summary

Problems solved by technology

[0004] However, due to the traditional freeze-drying process of this type of preparation, a large number of voids are formed, so the strength of the preparation is not high, it is easy to be brittle, and it needs to be formed in situ in the package and cannot be taken out. and template design limitations, only less than one-third of the freezing and lyophilizing capacity of the lyophilizer can be used

As Scherer concluded in its publication on Zydis, the high cost of production of traditional lyophilized excipients greatly limits its practical value