Preparation method of freeze-drying excipient

A technology of freeze-drying excipients and preparations, which is applied in the direction of freeze-drying transportation, making medicines into special physical or ingestible devices, powder transportation, etc., which can solve the problems of high production costs, limited practical value, and insufficient strength of preparations. Advanced problems, to achieve the effect of low product cost, diversified forms, and wide selection range

Pending Publication Date: 2018-05-25
董玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the traditional freeze-drying process of this type of preparation, a large number of voids are formed, so the strength of the preparation is not high, it is easy to be brittle, and it needs to be formed in situ in the package and cannot be taken out. and template design limitations, only less than one-third of the freezing and lyophilizing capacity of the lyophilizer can be used
As Scherer concluded in its publication on Zydis, the high cost of production of traditional lyophilized excipients greatly limits its practical value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] 304 stainless steel forming mold, the surface adopts spraying process, and the spraying material is polytetrafluoroethylene;

[0064] 20g of vitamin C, 10g of guar gum, and 23g of mannitol were dissolved in water to prepare a 1L solution;

[0065] The filling solution enters the molding mould, and 0.4ml of the solution is filled in each mould. After freeze-drying, it is taken out from the mould, packed into a double-aluminum package, and becomes a whitening lyophilized excipient preparation product for external use.

Embodiment 2

[0067] 316 stainless steel forming mold, the surface adopts sandblasting and spraying process, and the spraying material is polytetrafluoroethylene;

[0068] Dissolve 10g of pectin and 23g of mannitol in water to prepare a 1L solution;

[0069] Vitamin C dry powder 60g;

[0070] Fill vitamin C powder and the above solution into the forming mold, fill each mold with 60mg vitamin C powder and 0.4ml solution, after freeze drying, take it out from the mold, pack it into double aluminum packaging, and become external whitening freeze-dried excipients product.

Embodiment 3

[0072] 304 stainless steel forming mold, the surface adopts sandblasting and spraying process, and the spraying material is ceramic coating;

[0073] American ginseng extract 40g, Panax notoginseng extract 40g, mannitol 23g, pullulan 9g, dissolve in water, and make 1L solution;

[0074] The filling solution enters the forming mold, and each mold is filled with 1.2ml solution. After freeze-drying, it is taken out from the mold and packed into a plastic bottle to become a freeze-dried orally disintegrating tablet health product.

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PUM

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Abstract

The invention relates to a preparation method of a freeze-drying excipient, and particularly relates to the preparation method of the freeze-drying excipient which facilitates breaking away from the forming mould after freeze-drying by surface treatment of a forming mould.

Description

technical field [0001] The invention relates to a preparation method of a freeze-dried excipient preparation, in particular to a preparation method of a freeze-dried excipient preparation which facilitates separation from the molding mold after freeze-drying through surface treatment of a molding die. Background technique [0002] Freeze-drying excipient technology refers to adding a skeleton support agent and a binder to a flowable liquid, semi-solid or solid active ingredient, or the flowable liquid, semi-solid or solid itself contains a binder and a skeleton The support agent is then poured into a molding mold and shaped by a freeze-drying process. The preparation prepared by the freeze-drying excipient technology is called a freeze-dried excipient preparation. [0003] Because this type of preparation adopts a freeze-drying process, which can protect heat-sensitive components from being destroyed, and at the same time produce a large number of micropores and channels thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00A61K9/19
CPCA61J3/00A61K9/19
Inventor 董玲
Owner 董玲
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