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Cortex Moutan reference extract and its preparation method and application

A Cortex Moutan extract and Cortex Moutan technology are applied in the preparation of test samples, instruments, measuring devices, etc., to achieve the effects of being easy to use, ensuring consistency, and easy to operate

Active Publication Date: 2021-03-16
广州科曼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the Chinese medicine reference extract has the above-mentioned specific requirements, there is no or immature Moutan Cortex reference extract product prepared by using Moutan Cortex as a raw material in the prior art.

Method used

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  • Cortex Moutan reference extract and its preparation method and application
  • Cortex Moutan reference extract and its preparation method and application
  • Cortex Moutan reference extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Embodiment 1: Preparation of Cortex Moutan Reference Extract

[0084] The present embodiment provides the preparation method of Cortex Moutan reference extract of the present invention, and its method flowchart is as follows figure 1 shown.

[0085] One: extract

[0086] Select Moutan cortex medicinal material (Anhui, authentic medicinal material) and make it into powder, and the medicinal material powder is passed through a No. w / V)), ultrasonic (power 500w, normal temperature) extraction for 30min, medium-speed qualitative filter paper filtration, collect filter residue 1 and filtrate 1, filter residue 1 is extracted twice in the same way, and the filtrate and filtrate collected for the second time will be extracted again 1 The combination is the extract, and the extract is evaporated to dryness to obtain the dry paste;

[0087] Two: Preparation of Cortex Moutan Extract

[0088] After completely dissolving the dry paste with an appropriate amount of ethanol, add 4...

Embodiment 2

[0097] The character analysis of embodiment 2 Cortex Moutan reference extract

[0098] 1. Apparent state: the Cortex Moutan contrast extract that embodiment 1 obtains is yellow-white powder.

[0099] 2. Moisture determination: according to the 2015 edition Chinese Pharmacopoeia Appendix IX G (reduced pressure drying method). The test result shows that the water content of the Cortex Moutan control extract is 3.1%.

[0100] 3. Consistency test: 14 batches of Cortex Moutan reference extracts were prepared according to the method in Example 1, and the difference in TLC detection results for paeoniflorin and paeonol between each batch was determined to be very small. The fluorescent spots of corticosteroids were all clearly displayed, and the distribution was very consistent; the contents of paeoniflorin and paeonol were all within the range of the blending standard as detected by high performance liquid chromatography. Therefore, the Cortex Moutan reference extract prepared by ...

Embodiment 3

[0109] This example provides the application of the Cortex Moutan reference extract prepared in Example 1.

[0110] The commercially available medicinal materials were analyzed by thin-layer chromatography and high-performance liquid chromatography, respectively, with the chemical reference substance and Moutan Cortex reference extract as reference substances.

[0111] 1 TLC

[0112] 1.1 Sample preparation

[0113] Chemical reference solution: Accurately weigh paeoniflorin and paeonol, respectively, and prepare 1 mg / ml solutions with methanol.

[0114] Moutan cortex reference extract solution: Accurately weigh 0.2 g of Moutan cortex reference extract prepared in Example 1, add 10 ml of ethanol, ultrasonicate (500w) for 15 minutes, shake well, pass through a 0.22 μm filter membrane to obtain Moutan cortex reference extract substance solution.

[0115] Medicinal material for test solution: Take 1g of each medicinal material from the pharmacy, add 50ml of ethanol, take it out ...

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Abstract

The invention provides a tree peony bark control extract. The tree peony bark control extract is obtained by extracting different batches of tree peony bark medicinal material powders for several times to obtain different batches of tree peony bark extracts, and then blending the different batches of tree peony bark extracts to obtain the tree peony bark control extract. The tree peony bark control extract provided by the invention is prepared by blending the extracts of different batches, thereby ensuring the consistency of tree peony bark control extracts of different batches; moreover, thetree peony bark control extract is stable property, uniform and convenient to use. In application, the tree peony bark control extract is used as a control for quality control of tree peony bark and medicinal materials or traditional Chinese medicine preparations containing tree peony bark / tree peony bark effective ingredients. In the process of quality control, the tree peony bark control extractcan be directly used after simple processing, and the operation is simple and convenient. The tree peony bark control extract not only can be used for qualitative identification of medicinal materials or traditional Chinese medicine preparations, but also can be used for semi-quantitative or even quantitative analysis.

Description

technical field [0001] The invention relates to the technical field of quality control of traditional Chinese medicines, in particular to a control extract of Cortex Moutan and its application. Background technique [0002] Cortex Moutan is the dry root bark of the tree peony of the family Ranunculaceae. It has the functions of clearing heat and cooling blood, promoting blood circulation and removing stasis, and reducing asthenic fever. It is mainly produced in Hunan, Hubei, Anhui, Sichuan, Gansu, Shaanxi, Shandong, Guizhou and other places, among which Tongling, Anhui The quality produced by Fenghuang Mountain is the best. [0003] The current quality control mode of traditional Chinese medicine is basically following the development of natural medicinal chemistry, with the idea of ​​analysis methods targeting one or several active ingredients of traditional Chinese medicine and quality standards that can be both qualitative and quantitative, referring to the quality of for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/28G01N30/02G01N30/06G01N30/90
CPCG01N1/28G01N30/02G01N30/06G01N30/90
Inventor 郭隆钢陆顺瑶许舜军谢培山许铮弟张奕尧张和灿
Owner 广州科曼生物科技有限公司