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Multi-responsiveness hyperbranched polymer, preparation method, and application of same

A hyperbranched polymer, responsive technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problem of insufficient multi-responsive hyperbranched polymers, and achieve the effect of reasonable process and clear response

Active Publication Date: 2018-06-01
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with linear polymers or cross-linked network polymers, reports on multi-responsive hyperbranched polymers at home and abroad are far from enough

Method used

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  • Multi-responsiveness hyperbranched polymer, preparation method, and application of same
  • Multi-responsiveness hyperbranched polymer, preparation method, and application of same
  • Multi-responsiveness hyperbranched polymer, preparation method, and application of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of multi-responsive hyperbranched polymer adopts the method of Michael addition polymerization, and comprises the following steps:

[0042] (1) Preparation of p-diene azobenzene (AzoBA)

[0043] ①In a 100mL round bottom flask, add 50mL of tetrahydrofuran, 1.5032g of p-diaminoazobenzene and 2.08mL of triethylamine in sequence, and mix well under nitrogen protection; then slowly add 1.20mL of acryloyl chloride dropwise with a syringe under ice bath conditions , After the dropwise addition was completed, the reaction was stirred at room temperature for 5h.

[0044] ② Suction filtration: filter with a Buchner funnel and ordinary analytical filter paper with a diameter of 9 cm to obtain the upper solid.

[0045] ③Washing and centrifuging 3 times: the centrifuging speed is 9000rpm, 5 minutes each time, freeze-dried in liquid nitrogen for 5 minutes, and vacuum-dried (0kPa, 48h) to obtain yellow p-diene azobenzene (AzoBA) powder. The synthesis process T...

Embodiment 2

[0056] The preparation method of multi-responsive hyperbranched polymer is basically the same as embodiment 1.

[0057] The difference is:

[0058] (1) Preparation of p-diene azobenzene (AzoBA) (same as Example 1).

[0059] (2) Preparation of multi-responsive hyperbranched polymer (HPAzoAMAM)

[0060] ①In a 20mL screw bottle, add 0.6g of p-dieneazobenzene powder and dissolve it fully with dimethylformamide (DMF); then add the polyamine monomer 1-(2-aminoethyl)piperazine (AEPZ) 0.28mL, Michael addition reaction was carried out at 30°C under rapid stirring for 48h.

[0061] ② Precipitate with acetone, centrifuge three times, and dry in vacuum for 24 hours to obtain a yellow solid block product—multi-responsive hyperbranched polymer (HPAzoAMAM).

Embodiment 3

[0063] The preparation method of multi-responsive hyperbranched polymer is basically the same as embodiment 2.

[0064] The difference is:

[0065] (1) Preparation of p-diene azobenzene (AzoBA)

[0066] ①In a 100mL round bottom flask, add 50mL of tetrahydrofuran, 1.5032g of p-diaminoazobenzene and 2.96mL of triethylamine in sequence, and mix well under nitrogen protection; then slowly add 1.72mL of acryloyl chloride dropwise with a syringe under ice bath conditions , After the dropwise addition was completed, the reaction was stirred at room temperature for 5 hours.

[0067] ② (with embodiment 2).

[0068] ③ (with embodiment 2).

[0069] (2) Prepare multi-responsive hyperbranched polymer (HPAzoAMAM) (same as Example 2).

[0070] The multi-responsive functional analysis of the multi-responsive hyperbranched polymer prepared by the present invention:

[0071] (1) Photoresponsive analysis

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Abstract

The invention provides a multi-responsiveness hyperbranched polymer, wherein each branched arm contains an azo-benzene group and an amide group at the same time. A chemical structure formula of the hyperbranched polymer is represented as follows. A preparation method includes steps of: 1) preparing para-diene azobenzene to obtain a yellow para-diene azobenzene powder; 2) preparing the multi-responsiveness hyperbranched polymer to obtain a yellow solid multi-responsiveness hyperbranched polymer. The multi-responsiveness hyperbranched polymer has novel structure and triple-responsiveness of light, temperature and pH value. The preparation method has reasonable route and definite reaction and is easy to carry out. The multi-responsiveness hyperbranched polymer has application value in the fields of intelligent materials, photoelectric information storage and functional bio-medicine carriers, etc.

Description

technical field [0001] The invention relates to the technical field of polymers and their preparation, in particular to multi-responsive hyperbranched polymers and their preparation methods and applications. Background technique [0002] Multi-responsive polymer is a multi-responsive material that can change the conformation of polymer molecular chains under the condition of small changes in the external environment. Larger physical or chemical changes occur as a result of changes. This multi-responsive material has broad application prospects in the fields of smart materials, photoelectric storage, and biomedicine. At present, the temperature responsiveness, pH responsiveness, light responsiveness, ionic strength responsiveness, magnetic field responsiveness and other properties of multi-responsive polymers are the focus of researchers. [0003] Polymers containing amide groups are cationic polymers that are temperature and pH sensitive. The molecular structure of the po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K47/34
CPCA61K47/34C08G83/005
Inventor 林绍梁姚远孙柳英高飞
Owner EAST CHINA UNIV OF SCI & TECH