Method for preparing N-ethyl-N-hydroxyethylaniline

A technology of hydroxyethylaniline and ethylaniline, which is applied in the field of chemical synthesis, can solve the problems of large environmental pollution and many by-products, and achieve the effects of high chemical reaction efficiency, high utilization rate and good catalytic effect

Inactive Publication Date: 2018-06-05
JIANGSU YUANDA XIANLE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0023] The purpose of the present invention is to provide a new method for the synthesis of N-ethyl-N-hydroxyethylaniline that is easy to get, mild in reaction conditions, environmentally friendly, simple and efficient, to solve the problems of large environmental pollution, Too many by-products

Method used

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  • Method for preparing N-ethyl-N-hydroxyethylaniline
  • Method for preparing N-ethyl-N-hydroxyethylaniline
  • Method for preparing N-ethyl-N-hydroxyethylaniline

Examples

Experimental program
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Effect test

Embodiment 1

[0050] Purging the autoclave with nitrogen, under nitrogen protection, add the N-ethylaniline of 121g (1mol), the oxyethane of 44g (1mol), 1.2g (9.6mmol) taurine, close the autoclave lid, And tighten it, turn on the heating, raise the temperature to 90°C at a heating rate of 1°C / min, stop heating, raise the reaction temperature to 100°C and react for 6h, after the reaction is completed, cool to 40°C, and discharge to obtain N-ethyl-N- Hydroxyethylaniline 162g, yield 98.2%. 1 H NMR (400MHz, CDCl 3 )δ7.21(t, J=4.0Hz, 2H), 5.76(d, J=4.0Hz, 2H), 5.70(t, J=4.0Hz, 1H), 3.75(s, 2H), 3.43-3.48( m, 4H), 2.05(s, 1H), 1.13(t, J=4.0Hz, 3H).

Embodiment 2

[0052]Purging the autoclave with nitrogen, under the protection of nitrogen, add 121g (1mol) of N-ethylaniline, 46.2g (1.05mol) of ethylene oxide, 0.6g (4.8mmol) of taurine, close the autoclave Cover and tighten, turn on the heating, raise the temperature to 110°C at a heating rate of 1.5°C / min, stop heating, raise the reaction temperature to 140°C and react for 2 hours, after the reaction is completed, cool to 40°C, and discharge to obtain N-ethyl- N-hydroxyethylaniline 163.4g, yield 99%.

Embodiment 3

[0054] Purging the autoclave with nitrogen, under the protection of nitrogen, add 121g (1mol) of N-ethylaniline, 46.2g (1.05mol) of ethylene oxide, 0.91g (7.3mmol) of taurine, close the autoclave Cover and tighten, turn on the heating, raise the temperature to 100°C at a heating rate of 1.3°C / min, stop heating, raise the reaction temperature to 130°C for 3.5 hours, after the reaction is completed, cool to 40°C, and discharge to obtain N-ethyl -N-Hydroxyethylaniline 163.8g, yield 99.3%.

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Abstract

The invention discloses a method for preparing N-ethyl-N-hydroxyethylaniline. The method comprises the following steps: by taking N-ethylaniline and ethylene oxide as raw materials, in the absence ofa solvent, under catalysis of taurine, performing programmed heating, directly synthesizing N-ethyl-N-hydroxyethylaniline, cooling, and discharging, thereby obtaining a finished product. The method iseasy in raw material obtaining, good in atom economy, gentle in reaction condition, green and environment-friendly, simple and efficient and applicable to industrial production.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a method for preparing N-ethyl-N-hydroxyethylaniline. Background technique [0002] N-Ethyl-N-Hydroxyethylaniline is a very important organic intermediate, which is widely used in industrial fields such as dyes, pigments, and color developers. N-ethyl-N-hydroxyethylaniline can be used to prepare laser-treated wear-resistant paint; it can be used as a curing agent for unsaturated resins, a cross-linking agent for polyester paints; it can also be used as a metal anti-corrosion protection agent. Its hydroxyethyl group can greatly improve the dispersibility of dyes in synthetic fibers. In addition, a variety of aniline series derivatives and dye intermediates can be prepared through aminolysis, esterification, acetylation, chlorination, and dehydration of the hydroxyl group. In short, N-ethyl-N-hydroxyethylaniline has a wide range of uses. With the continuous development ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C215/68C07C213/04
CPCC07C213/04C07C215/68
Inventor 赵百合刘年金张邦国冯永华张军桥杜艳罗群
Owner JIANGSU YUANDA XIANLE PHARMA
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