Chitosan containing antibacterial foaming agent for gynecology and preparation method thereof

A technology of foam agent and chitosan, which is applied in the field of medicine, can solve the problems of vaginal mucosa irritation, hidden antibacterial ingredients, and harm to the safety of the genitals, and achieve the effects of low irritation, control of bacterial infection, and high safety

Inactive Publication Date: 2018-06-15
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are defects in the existing technology, such as the use of propane butane and other propellants, which will cause certain irritation to the vaginal mucosa; the addition of benzalkonium chloride, nano-silver, etc. not only irritate the skin, hurt the genitals, but

Method used

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  • Chitosan containing antibacterial foaming agent for gynecology and preparation method thereof
  • Chitosan containing antibacterial foaming agent for gynecology and preparation method thereof
  • Chitosan containing antibacterial foaming agent for gynecology and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A gynecological antibacterial foam containing chitosan, said gynecological antibacterial foam containing chitosan is made from the following raw materials in parts by weight: 0.5 part of chitosan quaternary ammonium salt, 1 part of chitosan , 0.5 parts of sodium hyaluronate, 0.5 parts of 1,3-butanediol, 0.01 parts of oat β-glucan, 0.2 parts of natural lactic acid, 2 parts of glycerin, 0.04 parts of foaming agent, and 75 parts of purified water.

[0029] The degree of deacetylation of the chitosan or the chitosan quaternary ammonium salt is 90%; the molecular weight of the chitosan or the chitosan quaternary ammonium salt is 5000. The molecular weight of the oat β-glucan is 20,000. The foaming agent is alkylphenol polyoxyethylene ether.

[0030] A preparation method for gynecological antibacterial foam containing chitosan, comprising the following steps:

[0031] 1) Add the amount of chitosan quaternary ammonium oat β-glucan and sodium hyaluronate into a certain amount...

Embodiment 2

[0035] A gynecological antibacterial foam containing chitosan, said gynecological antibacterial foam containing chitosan is made from the following raw materials in parts by weight: 2 parts of chitosan quaternary ammonium salt, 5 parts of chitosan , 2 parts of sodium hyaluronate, 01 parts of 1,3-butanediol, 1 part of oat beta-glucan, 2 parts of natural lactic acid, 5 parts of glycerin, 1 part of foaming agent, and 105 parts of purified water.

[0036] The degree of deacetylation of the chitosan or the chitosan quaternary ammonium salt is 98%; the molecular weight of the chitosan or the chitosan quaternary ammonium salt is 250,000. The molecular weight of the oat β-glucan is 150,000. The foaming agent is alkylphenol polyoxyethylene ether.

[0037] A preparation method for gynecological antibacterial foam containing chitosan, comprising the following steps:

[0038] 1) Add the amount of chitosan quaternary ammonium salt, oat β-glucan, and sodium hyaluronate to the

[0039] A ...

Embodiment 3

[0044] A gynecological antibacterial foam containing chitosan, said gynecological antibacterial foam containing chitosan is made from the following raw materials in parts by weight: 1 part of chitosan quaternary ammonium salt, 2 parts of chitosan , 1 part of sodium hyaluronate, 0.7 parts of 1,3-butanediol, 0.09 parts of oat β-glucan, 0.8 parts of natural lactic acid, 2.5 parts of glycerin, 0.1 parts of foaming agent, and 85 parts of purified water.

[0045] The degree of deacetylation of the chitosan or the chitosan quaternary ammonium salt is 92%; the molecular weight of the chitosan or the chitosan quaternary ammonium salt is 150,000. The molecular weight of the oat β-glucan is 80,000. The foaming agent is alkylphenol polyoxyethylene ether.

[0046] A preparation method for gynecological antibacterial foam containing chitosan, comprising the following steps:

[0047] 1) Add the amount of chitosan quaternary ammonium salt, oat β-glucan, and sodium hyaluronate to the

[004...

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Abstract

The invention relates to a chitosan containing antibacterial foaming agent for gynecology and a preparation method thereof, and belongs to the medicine field. The foaming agent is prepared from following raw materials in parts by weight: 0.5 to 2 parts of chitosan quaternary ammonium salt, 1 to 5 parts of chitosan, 0.5 to 2 parts of sodium hyaluronate, 0.5 to 1 part of 1,3-butylene glycol, 0.01 to1 part of oat beta-glucan, 0.2 to 2 parts of natural lactic acid, 2 to 5 parts of glycerin, 0.04 to 1 part of foaming agent, and 75 to 105 parts of purified water. The raw materials can generate a prominent synergistic effect on preventing pathogenic bacteria of colpitis. The foaming agent has a good antibacterial effect. Moreover, the irritation on vaginas is little, and the foaming agent is suitable for the treatments on gynecologic inflammation such as colpitis, cervicitis, and the like, and can be used to repair wounds of vagina mucosa.

Description

technical field [0001] The invention relates to a gynecological antibacterial foam containing chitosan and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Gynecological inflammation is a common disease and frequently-occurring disease, including vaginitis, cervicitis, etc. It is an inflammation caused by pathogenic bacteria invasion due to external injury or infection. Gynecological inflammation is a common disease that plagues the majority of female patients. The treatment of gynecological inflammation is mainly to remove or kill pathogens through local administration, restore the normal microenvironment, and repair damaged tissues, so as to achieve a healing effect. Vaginal mucosal drug administration has a history of nearly a hundred years. Compared with traditional oral drugs, it has many advantages. It is an effective drug sustained release system. It can be used not only locally, but also systemically. Increase the loca...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/722A61K31/728A61K47/36A61P15/02A61P31/02A61P31/04A61K31/716
CPCA61K9/0034A61K9/122A61K31/716A61K31/722A61K31/728A61K47/36A61K2300/00
Inventor 黄海艳车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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