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Three-layer structural composite artificial blood vessel

An artificial blood vessel, three-layer structure technology, applied in the field of medical devices, can solve the problems of restricting the fusion of vascular prostheses, low blood permeation, and difficulty in fully growing cells into the tube wall, etc., achieving good repeatability, promoting integration, and good The effect of the application foreground

Inactive Publication Date: 2018-06-22
SHANGHAI CHANGDY MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Multi-layer composite artificial blood vessels, such as GOREACUSEAL Vascular Graft (National Machinery Injection 20153462072), the inner and outer layers of this product are ePTFE, and the middle layer is a silicone layer with low blood permeability. Because the ePTFE pore size of the inner and outer layers is small, Makes it difficult for cells to fully grow into the vessel wall, which limits the fusion of vascular prostheses with human tissue

Method used

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  • Three-layer structural composite artificial blood vessel
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  • Three-layer structural composite artificial blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Please refer to figure 2 , a straight three-layer structure artificial blood vessel, the inner diameter of the blood vessel is 5mm, the length is 45cm, and the thickness of the tube wall is 487 microns. Tube wall thickness refers to the total thickness of dense hemostatic layer 1, elastomer layer 2, and fiber-reinforced layer 3.

[0021] The thickness of the artificial blood vessel wall and the thickness of each layer of the wall are measured by a thickness gauge at a pressure of 17.5kPa and a presser foot area of ​​50mm. 2 Test under certain conditions: Measure a point every 2cm in the horizontal direction, measure 5 points in total, and calculate the average value of all measurement points. The porosity of each layer is tested by the method of liquid substitution: use ethanol as the substitution liquid, put the material into a known volume (V 1 ) in ethanol solution, after 10 minutes, record the mixed volume of ethanol and material (V 2 ), remove the material from...

Embodiment 2

[0026] Please refer to image 3 , a variable-diameter cylindrical three-layer artificial blood vessel, the inner diameter of the blood vessel is 4-7mm (the inner diameter is continuously and gradually changed), the length is 45cm, and the thickness of the tube wall is 577 microns. For the thickness, porosity and pore diameter test methods of each layer of the pipe body, refer to Example 1. The inner layer is a PU nanofiber layer with a thickness of 116 microns, a porosity of 75%, and an average pore diameter of 0.8 microns; the middle layer is a microporous polyurethane layer with a thickness of 252 microns, a porosity of 70%, and an average pore diameter of 26 microns ; The outer layer is warp-knitted polytetrafluoroethylene fibers with a thickness of 209 microns, a porosity of 45%, and an average pore size of 154 microns. Referring to Example 1, the water seepage performance of the artificial blood vessel was tested, and the water seepage measured at 16kPa was 0. Bending e...

Embodiment 3

[0028] Please refer to Figure 4 , a cylindrical three-branch three-layer structure artificial blood vessel, the inner diameter of the main body is 20 mm, the length is 40 cm, and the thickness of the tube wall is 535 microns. The thickness, porosity and pore diameter test methods of each layer of the main body and branches refer to Example 1. The inner layer of the main body is a PU nanofiber layer with a thickness of 147 microns, a porosity of 78%, and an average pore diameter of 1.1 microns; the middle layer is microporous silica gel with a thickness of 173 microns, a porosity of 63%, and an average pore diameter of 53 microns ; The outer layer is a fabric made of PET fibers through warp knitting, with a thickness of 215 microns, a porosity of 48%, and an average pore size of 164 microns. The internal diameter of the branches is 8 mm, the length is 15 cm, and the wall thickness of the tube is 443 microns. The inner layer of the branches is a PU nanofiber layer with a thic...

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Abstract

The invention discloses a three-layer structural composite artificial blood vessel, and belongs to the field of medical apparatuses. The three-layer structural composite artificial blood vessel is composed of a dense blood retaining layer, an elastomer layer and a fiber-reinforced layer, wherein the dense blood retaining layer is arranged on the inner surface of a vessel body; the elastomer layeris arranged in the middle of the vessel body; and the fiber-reinforced layer is arranged on the outer surface of the vessel body. Pores are distributed in the blood retaining layer, the elastomer layer and the fiber-reinforced layer; and the size of the pores follows a trend of being increased from inner layer to outer layer. Blood retaining performance, tissue growth-in performance, anti-thrombotic property, mechanical strength and thickness of various layers of the artificial blood vessel are in gradient change; the blood retaining performance has a trend of being increased from outer layerto inner layer; the cell growth-in performance has a trend of being decreased from outer layer to inner layer; the anti-thrombotic property has a trend of being increased from outer layer to inner layer; and the mechanical strength has a trend of being decreased from outer layer to inner layer. The three-layer structural composite artificial blood vessel provided by the invention is excellent in penetration resistance, anti-thrombotic property, compliance, bio-compatibility and mechanical performance.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a three-layer composite artificial blood vessel with good permeability resistance, antithrombotic performance, compliance, biocompatibility and mechanical properties. Background technique [0002] The vascular system includes the heart, blood vessels, and blood. The heart transports fresh blood to various parts of the body through large and small blood vessels to exchange nutrients and waste in the body to ensure the normal function of various organs. However, atherosclerosis, hemangioma, and external trauma cause a variety of arterial and venous vascular defects, and it is necessary to use vascular substitutes of different diameters through surgery to replace the corresponding diseased blood vessel, bypass and other repair treatments. Blood vessel substitutes generally include autologous blood vessels, xenograft blood vessels, allogeneic blood vessels, and artificial ...

Claims

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Application Information

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IPC IPC(8): A61F2/06
CPCA61F2/06A61F2210/0076
Inventor 杜广武陈剑锋
Owner SHANGHAI CHANGDY MEDICAL CO LTD
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