Polyvinyl alcohol nanofiber emboliaztion agent as well as preparation method and application thereof

A nanofiber, polyvinyl alcohol technology, applied in the application, nanotechnology, nanotechnology and other directions, can solve problems such as drift, achieve the effect of reducing the number of times, reducing the economic burden, and reliable embolization

Inactive Publication Date: 2018-06-22
EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, some embolic agents used clinically drift after embolization of blood vessels, that is, they leave the predetermined site and enter other blood vessels, causing ischemic necrosis of normal tissues

Method used

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  • Polyvinyl alcohol nanofiber emboliaztion agent as well as preparation method and application thereof
  • Polyvinyl alcohol nanofiber emboliaztion agent as well as preparation method and application thereof
  • Polyvinyl alcohol nanofiber emboliaztion agent as well as preparation method and application thereof

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preparation example Construction

[0038] The embodiment of the present application also provides a preparation method of the above-mentioned polyvinyl alcohol nanofiber embolic agent, such as figure 1 As shown, it specifically includes the following steps:

[0039] Step S110: Dissolving the polyvinyl alcohol particles in water and heating until completely dissolved to form an aqueous solution of polyvinyl alcohol with a suitable concentration as an electrospinning solution;

[0040] In this step, when dissolving the polyvinyl alcohol, it can be heated in an oil bath / water bath under magnetic stirring until the PVA is completely dissolved, cooled and defoamed, and used as an electrospinning solution for later use.

[0041] Wherein, the concentration of the polyvinyl alcohol aqueous solution is 5%-10%, and the heating temperature is 85-95°C. Appropriate PVA concentration can ensure continuous nanofibers. If the concentration of PVA solution is too high, the viscosity of the system will be high, and the needle w...

Embodiment 1

[0057] A preparation method of PVA nanofiber embolic agent, comprises the steps:

[0058] S1: First measure 9.2ml of ultra-pure water and put it in a beaker, weigh 0.8g of PVA1799 powder and add it slowly, then mechanically stir and heat in an oil bath at 90°C for 1 hour to become transparent and viscous, cool and defoam for later use , configured as a spinning dope;

[0059] S2: Use a 20ml syringe equipped with a stainless steel needle to draw the spinning stock solution, use the needle as the positive pole, and the aluminum foil paper as the negative pole, set the receiving distance of the positive and negative poles to 15cm, the spinning voltage to 18KV, the propulsion rate to 0.9ml / h, and the temperature to 30°C , PVA nanofiber film was prepared by electrospinning;

[0060] S3: Carefully remove the PVA nanofiber film from the aluminum foil, and dry it in vacuum at 150°C for 15 minutes to obtain a PVA nanofiber film with good water resistance;

[0061] S4: The heat-treate...

Embodiment 2

[0069] A preparation method of PVA nanofiber embolic agent, comprises the steps:

[0070] S1: First measure 9.5ml of ultra-pure water and put it in a beaker, weigh 0.5g of PVA1799 powder and add it slowly, then mechanically stir and heat in an oil bath at 85°C for 1 hour to become transparent and viscous, cool and defoam for later use , configured as a spinning dope;

[0071] S2: Use a 20ml syringe equipped with a stainless steel needle to absorb the spinning stock solution, use the needle as the positive pole, and the aluminum foil paper as the negative pole, set the receiving distance of the positive and negative poles to 5cm, the spinning voltage to 16KV, the propulsion rate to 0.1ml / h, and the temperature to 30°C , PVA nanofiber film was prepared by electrospinning;

[0072] S3: Carefully remove the PVA nanofiber film from the aluminum foil, and dry it in vacuum at 100°C for 80 minutes to obtain a PVA nanofiber film with good water resistance;

[0073] S4: The heat-treat...

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Abstract

The invention discloses a polyvinyl alcohol nanofiber emboliaztion agent as well as a preparation method and application thereof and belongs to the field of vascular thrombosis materials for interventional therapy. The polyvinyl alcohol nanofiber emboliaztion agent consists of polyvinyl alcohol electrostatic spinning nanofiber granules, wherein the particle sizes of the nanofiber granules is 100-300mu m. The preparation method comprises the following steps: dissolving polyvinyl alcohol granules into water, and heating till the polyvinyl alcohol granules are completely dissolved so as to obtaina polyvinyl alcohol solution of an appropriate concentration as an electrostatic spinning solution; preparing a polyvinyl alcohol nanofiber film from the electrostatic spinning solution by using electrostatic spinning equipment; performing thermal treatment on the nanofiber film; shearing the nanofiber film after thermal treatment, performing low-temperature crushing treatment, and screening, thereby obtaining the polyvinyl alcohol nanofiber granules of which the particle size is 100-300mu m. The emboliaztion agent disclosed by the invention has relatively good treatment effects and biological security, and can be also applied to arterial embolism of various types of malignant tumor such as primary liver cancer and kidney cancer.

Description

technical field [0001] The invention relates to the field of vascular embolic materials for interventional therapy, in particular to a polyvinyl alcohol nanofiber embolic agent and its preparation method and application. Background technique [0002] With the development of modern clinical medicine, transcatheter arterial embolization (TAE), as an important technique in interventional therapy, has become increasingly mature, endowing traditional medical treatment and surgical treatment with new significance. In short, it is to controlly inject artificial vascular embolism into the target supply blood vessel of the lesion, make it occluded, block the blood supply, and achieve the purpose of treating tumor, hemostasis and eliminating the function of diseased organs. This technique has many advantages such as minimal invasiveness, good targeting and high curative effect, so it has received more and more attention. The choice of embolic agent is critical to the effectiveness of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06B82Y5/00
CPCA61L24/06A61L2400/12A61L2430/36B82Y5/00C08L29/04
Inventor 杨光李晓宏李拔森王良张耀鹏
Owner EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH
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