Preparation method of thiamine pyrophosphate tetrahydrate in 12 vitamin raw materials for injection

A technology of thiamine pyrophosphate tetrahydrate and thiamine pyrophosphate, which is applied in the field of preparation of 12 kinds of vitamin raw materials for injection, thiamine pyrophosphate tetrahydrate, can solve the problems of long production cycle, environmental pollution and the like, and achieves The effect of reducing production cost, reducing environmental pollution and mild reaction conditions

Inactive Publication Date: 2018-06-22
SHANXI PUDE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the preparation method of the prior art, there is a long production cycle, and the

Method used

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  • Preparation method of thiamine pyrophosphate tetrahydrate in 12 vitamin raw materials for injection
  • Preparation method of thiamine pyrophosphate tetrahydrate in 12 vitamin raw materials for injection
  • Preparation method of thiamine pyrophosphate tetrahydrate in 12 vitamin raw materials for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of 12 kinds of vitamin raw materials thiamine pyrophosphate tetrahydrate for injection, characterized in that the preparation method comprises the following steps:

[0035] (1) Soak 2kg of Amberlite resin with 0.1mol / L HCl of 3.3L for 0.5h, filter, then repeatedly wash twice with 0.1mol / L HCl, filter, and dry to obtain acid-treated Amberlite resin;

[0036] (2) Soak the Amberlite resin that the acid treatment of step (1) gained is crossed 0.5h with 5% NaOH solution, filter, wash 2 times with 5% NaOH solution then, filter, wash the Amberlite resin that alkali treatment is crossed with distilled water, obtain Activated Amberlite resin; store the activated resin in a -4°C environment for future use.

[0037] (3) The activated 2kg Amberlite resin obtained in step (2) is placed in a container, then an appropriate amount of distilled water is added, vigorously stirred to drive out the air bubbles as much as possible, then the column packing takes by weigh...

Embodiment 2

[0040] This embodiment relates to the quality detection of thiamine pyrophosphate tetrahydrate obtained in embodiment 1. The test results are shown in the table below:

[0041] Quality Test Data Sheet for Thiamine Pyrophosphate Tetrahydrate

[0042]

[0043]

[0044] It can be seen from the above table that the quality of thiamine pyrophosphate tetrahydrate prepared according to the method of the present application is qualified, and the yield and content are high.

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PUM

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Abstract

The invention discloses a preparation method of thiamine pyrophosphate tetrahydrate in 12 vitamin raw materials for injection. The preparation method comprises the following steps: (1) acidizing of Amberlite resin to obtain acid-treated Amberlite resin; (2) activating the acid-treated Amberlite resin to obtain activated Amberlite resin; (3) packing the activated Amberlite resin; preparing a thiamine pyrophosphate hydrochloride solution, loading, reducing pressure and chromatographing by using distilled water as a mobile phase, and post-treating the eluate to obtain a crude product of thiaminepyrophosphate tetrahydrate; (4) dissolving the crude product of thiamine pyrophosphate tetrahydrate in water to form a thiamine pyrophosphate tetrahydrate solution; adding anhydrous ethanol to the solution until a turbid phenomenon appears, heating to complete dissolution, still standing, and filtering to obtain the thiamine pyrophosphate tetrahydrate.

Description

technical field [0001] The application belongs to the technical field of medicine preparation, more specifically, the application relates to a preparation method of 12 kinds of vitamin raw materials tetrahydrate thiamine pyrophosphate for injection. Background technique [0002] 12 kinds of compound vitamins for injection, the indication is that this product is intravenous vitamin supplementation. It is suitable for those who have insufficient nutritional intake through the gastrointestinal tract. Each bottle of injection contains: vitamin A palmitate (vitamin A1) equivalent to retinol 3500IU; cholecalciferol (vitamin D 3 ) 220IU; racemic α-tocopherol (vitamin E) 10.22㎎, equivalent to α-tocopherol 11.200IU; ascorbic acid (vitamin C) 125.000㎎; thiamine pyrophosphate tetrahydrate (vitamin B1) 5.800㎎; phosphate dihydrate Sodium riboflavin (vitamin B 2 ) 5.500㎎, equivalent to riboflavin 4.140㎎; pyridoxine hydrochloride 4.530㎎; cobalamin (vitamin B12) 0.006㎎; folic acid 0.414㎎...

Claims

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Application Information

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IPC IPC(8): C07F9/6558
CPCC07F9/65583
Inventor 李立忠王勇荣航张芳芳李海娇李述天
Owner SHANXI PUDE PHARMA CO LTD
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