Ocular surface treatment device and preparation method thereof

Abstract

The invention provides an ocular surface treatment device. The device comprises a cornea fixing ring and a chitosan electrospinning membrane fixed on the cornea fixing ring; and the chitosan electrospinning membrane has a radian matched with an ocular surface. The invention further provides a preparation method of the ocular surface treatment device. When the ocular surface treatment device is used, the cornea fixing ring is in close contact with the cornea, so that the chitosan electrospinning membrane is closely attached to the ocular surface, thereby avoiding secondary suture of the damagedcornea. Chitosan has good properties of bacteria resistance, anti-inflammatory, breathability, oxygen permeability, and the like, does not cause irritation to the ocular surface, has good comfort, good moisturizing effects, and can prevent damage to the ocular surface caused by diseases such as dry eye, and keep the microenvironment of the ocular surface stable. The chitosan electrospinning membrane has a nano-space structure, can adsorb drugs such as eye drops, stem cell suspensions and the like, and with the degradation of chitosan, the drug is slowly released, thereby reducing the number of drug administration.

Description

technical field [0001] The invention relates to the technical field of eye care and treatment, in particular to an ocular surface treatment device and a preparation method thereof. Background technique [0002] The cornea is located at the front of the eyeball and is exposed to the air for a long time. The cornea is composed of: epithelial cell layer, Bowman's membrane, stroma layer, Bowman's membrane and endothelial cell layer. The surface of the cornea is covered with a layer of tear film of 0.02-0.05 nanometers. The tear film is mainly composed of mucin layer, aqueous layer and lipid layer. Its main function is to protect the corneal epithelium in a good microenvironment. The tear film and cornea together constitute the first refractive system of the human eye, and damage to the tear film and cornea will cause discomfort to the human eye and even affect vision. At present, factors such as the deterioration of the air environment, the emergence of electronic products, and...

AI Technical Summary

Problems solved by technology

However, because amnion is of allogeneic origin, biological sources are limited

The curative effect of fresh amniotic membrane on ocular surface diseases is better, but the detection of fresh amniotic membrane bacteria is mostly done by the hospital itself, and the standard is difficult to determine the risk of potential disease transmission. At the same time, fresh amniotic membrane is inconvenient to process, maintain, and transport, which is not conducive to wide application

Bio-freeze-dried amniotic membrane has limited efficacy, limited sources, cumbersome processing steps, and potential risk of disease transmission

In addition, due to the different sources of biological amniotic membranes, the therapeutic effects of different batches of amniotic membranes vary greatly, and the standards are difficult to unify.

Images