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Hydrogel with multiple stimulus response as well as preparation method and application thereof

A multi-stimulus-responsive, hydrogel technology, applied in biochemical equipment and methods, medical preparations with non-active ingredients, chemical instruments and methods, etc. question

Active Publication Date: 2018-07-06
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although people have developed many gelling factors with different applications such as drug loading, it has been a challenge to achieve multiple stimuli responsiveness and multiple applications of hydrogels using a single gelling factor.

Method used

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  • Hydrogel with multiple stimulus response as well as preparation method and application thereof
  • Hydrogel with multiple stimulus response as well as preparation method and application thereof
  • Hydrogel with multiple stimulus response as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The 1,3:2,4-(o-hydroxybenzyl)sorbitol (2-HDBS) hydrogel can be prepared by the following four methods:

[0029] Method 1: The dicondensate 2-HDBS of sorbitol and salicylaldehyde is used as a hydrogel factor, heated in water to a dissolved state, and cooled to room temperature to form a gel. Specifically, in a sealed vial containing 10 mg of compound 2-HDBS, add 1 mL of water, heat it to 100 °C to dissolve it completely, and cool it to room temperature to form an opaque gel, which is 2-HDBS hydrogel (such as figure 1 shown).

[0030] Method 2: Compound 2-HDBS can form a gel in water, sonicated in ultrasonic waves, heated to a dissolved state and cooled to room temperature. Specifically, add 1 mL of water to a sealed vial containing 10 mg of 2-HDBS, sonicate for 5 min at 20 °C and ultrasonic power of 90 W, heat to 100 °C to become a solution, and cool to room temperature to form an opaque gel, which is 2 -HDBS hydrogel.

[0031] Method 3: Compound 2-HDBS is heated to a...

Embodiment 2

[0034] Preparation of 1,3:2,4-(m-hydroxybenzyl)sorbitol hydrogel

[0035] Using 1,3:2,4-(m-hydroxybenzyl)sorbitol as a hydrogel factor, it can be heated to a dissolved state in water and cooled to room temperature to form a gel. Specifically, in a sealed vial containing 10 mg of compound 1,3:2,4-(m-hydroxybenzyl)sorbitol, add 1 mL of water, heat it to 100°C to dissolve it completely, and cool it to room temperature to form an opaque gel, That is 1,3:2,4-(m-hydroxybenzyl)sorbitol hydrogel.

Embodiment 3

[0037] Preparation of 1,3:2,4-(p-hydroxybenzyl)sorbitol hydrogel

[0038] Substituting 1,3:2,4-(p-hydroxybenzyl)sorbitol for 1,3:2,4-(m-hydroxybenzyl)sorbitol in Example 2, an opaque hydrogel can be obtained

[0039] Multiple stimulus responses of hydrogels (illustrated with 2-HDBS hydrogel representatives)

[0040] Thermal response: The 2-HDBS hydrogel has a thermally reversible property, that is, it becomes a sol after heating, and a gel is formed again after cooling, and this process can be repeated many times.

[0041]Acid-base response: Put different doses of solid base (sodium hydroxide or sodium bicarbonate) into 2-HDBS hydrogel, the gel will gradually become a solution when the base dose is 2mM-5mM. After adding a certain amount of hydrochloric acid (2-5mM), the solution turns back to a gel, which can realize the reversible transformation of the gel solution. Similarly, put different doses of acid (concentrated hydrochloric acid or trifluoroacetic acid) on the gel pr...

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PUM

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Abstract

The invention discloses hydrogel with multiple stimulus response as well as a preparation method and application thereof. The preparation method comprises the following steps: adding a polyol double acetal compound into water, heating to dissolve the polyol double acetal compound, and cooling to room temperature to obtain hydrogel, wherein the polyol double acetal compound is generated by performing condensation reaction on a polyol compound containing 4 to 6 hydroxyl groups and an aromatic aldehyde compound. In addition, the hydrogel has various kinds of applicability of chirally identifyingchiral amino acid and an epimer medicine, adsorbing dye in waste water, serving as a medicine carrier, proliferating cells and the like.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and in particular relates to a hydrogel with multiple stimulus responses and a preparation method and application thereof. Background technique [0002] Significant achievements in supramolecular science have prompted more urgent search for next-generation functional materials, especially stimuli-responsive soft matter, which can promote the development of multifunctional materials suitable for emerging technologies. As a kind of irritating soft materials, supramolecular hydrogels can respond to many chemical and physical stimuli and can produce reversible phase transitions under the action of non-covalent bonds. In recent years, the construction of low-molecular-weight hydrogels with multiple stimuli responsiveness has become a research hotspot, because the more stimuli-responsiveness, the greater the flexibility for the creation of smart materials. However, there are few hydrogelators w...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08G16/02C02F1/28A61K9/06A61K47/34C12N5/00C02F101/36C02F101/38C08L61/00
CPCA61K9/06A61K47/34C02F1/285C02F2101/308C02F2101/36C02F2101/38C08G16/0225C08J3/075C08J2361/00C12N5/0062C12N2533/30
Inventor 管西栋韩小玉张芳芳张吉梅
Owner TAISHAN MEDICAL UNIV
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