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Sulfanilic acid-modified gold-silver alloy nanoparticle colorimetric sensor and application thereof

A p-aminobenzenesulfonic acid and colorimetric sensor technology, applied in the field of analytical chemistry, can solve the problems of poor performance, inconvenient operation, and low accuracy of the ractopamine colorimetric sensor, and achieve good application prospects, simple operation, and short detection time short effect

Active Publication Date: 2018-07-10
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention aims at the technical defects of the prior art, and provides a gold-silver alloy nanoparticle colorimetric sensor based on p-aminobenzenesulfonic acid modification and its application, so as to solve the problems in the prior art for detecting ractopamine by colorimetry. Technical issues with poor colorimetric sensor performance
[0008] Another technical problem to be solved by the present invention is that the conventional detection method for ractopamine in the prior art is inconvenient to operate and has low accuracy

Method used

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  • Sulfanilic acid-modified gold-silver alloy nanoparticle colorimetric sensor and application thereof
  • Sulfanilic acid-modified gold-silver alloy nanoparticle colorimetric sensor and application thereof

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Embodiment 1

[0032] A colorimetric sensor based on gold-silver alloy nanoparticles modified by p-aminobenzenesulfonic acid was prepared by the following method: accurately pipette 48 μL of 1.0% (w / w) AgNO 3 solution and 47 μL of 1.0% (w / w) HAuCl 4 The solutions were added to flasks containing 15mL ultrapure water, condensed and refluxed for 5 minutes, then 250 μL of 0.4mM trisodium citrate solution was added at the same time, heated for another 2 minutes, then mixed immediately and continued to stir and heat for 15 minutes to obtain a clear and stable orange color The solution is the gold-silver alloy nanoparticle solution;

[0033] In above-mentioned newly synthesized gold-silver alloy solution, add 1mL1.0mM p-aminobenzenesulfonic acid solution and stir 2h at a constant speed, obtain the gold-silver nano-alloy solution modified by p-sulfanilic acid. The p-aminobenzenesulfonic acid concentration concentration in the gold-silver nano-alloy solution modified by p-aminobenzenesulfonic acid i...

Embodiment 2

[0077] A colorimetric sensor based on gold-silver alloy nanoparticles modified by p-aminobenzenesulfonic acid was prepared by the following method: take 48 μL of AgNO with a concentration of 1.0% (w / w) 3 solution and 47 μL of 1.0% (w / w) HAuCl 4 Each solution was added to 15mL ultrapure water, condensed and refluxed and heated for 5min, then 250μL of 0.4mM trisodium citrate solution was added to each solution, continued to heat for 2min, then mixed and continued to heat for 15min under stirring conditions, and then added 1mL of p-aminobenzenesulfonic acid solution with a concentration of 1mM was stirred at a constant speed for 2h to obtain a p-sulfanil-acid-modified gold-silver nano-alloy solution, which was the colorimetric sensor based on p-sulfanil-acid-modified gold-silver alloy nanoparticles. The gold-silver nano-alloy solution modified by sulfanilic acid contains 30 μM sulfanilic acid. The pH value of the gold-silver nano-alloy solution modified by p-aminobenzenesulfonic...

Embodiment 3

[0082] A colorimetric sensor based on gold-silver alloy nanoparticles modified by p-aminobenzenesulfonic acid was prepared by the following method: take 48 μL of AgNO with a concentration of 1.0% (w / w) 3 solution and 47 μL of 1.0% (w / w) HAuCl 4 Each solution was added to 15 mL of ultrapure water, condensed and refluxed for 5 min, and 250 μL of 0.4 mM trisodium citrate solution was added to it, and continued to heat for 2 min, then mixed and continued to heat for 15 min under stirring conditions, and then added 1 mL of The p-aminobenzenesulfonic acid solution with a concentration of 1 mM was stirred at a constant speed for 2 hours to obtain a p-aminobenzenesulfonic acid-modified gold-silver nano-alloy solution, which was the colorimetric sensor based on p-sulfanilic acid-modified gold-silver alloy nanoparticles. The gold-silver nano-alloy solution modified by sulfanilic acid contains 30 μM sulfanilic acid.

[0083] The application of the above-mentioned colorimetric sensor for...

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Abstract

The invention provides a sulfanilic acid-modified gold-silver alloy nanoparticle colorimetric sensor and an application thereof. A citrate radical is used as a reducing agent and a protective agent simultaneously, HAuCl4 and AgNO3 are simultaneously reduced through condensing reflux experiments by adopting a chemical reduction method, and the gold-silver alloy nanoparticle with the particle size of 50 nm is prepared and characterized. The surface of the alloy nanoparticle is modified with sulfanilic acid as an identification molecule to establish a colorimetric sensing analysis method for rapidly detecting ractopamine. The method has a good selectivity to ractopamine under optimized experimental conditions, the ractopamine detection concentration is 15.0-105.0 nM, and the lowest detectionlimit is 5.0 nM. The method has the advantages of good selectivity, simplicity in operation, short detection time and low cost, can be used for detecting ractopamine in pork, pig feeds, pig urine andother actual samples, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry, and further relates to a colorimetric detection technology based on nanomaterials, in particular to a gold-silver alloy nanoparticle colorimetric sensor modified by p-aminobenzenesulfonic acid and its application. Background technique [0002] Colorimetric detection is based on the color reaction that generates colored compounds, and is a method to determine the content of the components to be tested by comparing or measuring the color depth of the colored substance solution. In recent years, based on the special size effect, volume effect, macroscopic quantum tunneling effect and surface effect of nanomaterials, colorimetric detection methods based on nanomaterials have received extensive attention. The colorimetric detection of nanomaterials is based on their strong surface plasmon resonance under visible light, and the properties of different colors in the dispersed and aggregated...

Claims

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Application Information

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IPC IPC(8): G01N21/78G01N21/31
CPCG01N21/314G01N21/78G01N2021/3155
Inventor 张国文杜佳炜潘军辉胡兴
Owner NANCHANG UNIV
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