Recombinant collagen hydrogel wound dressing and preparation method and application thereof

A technology for reconstituting collagen and wound dressings, applied in pharmaceutical formulations, pharmaceutical sciences, bandages, etc., can solve the problems of cytotoxicity, complicated preparation steps, etc., and achieve the effects of good biocompatibility, simple preparation, and reduction of scar formation.

Inactive Publication Date: 2018-07-13
江苏创铭医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a recombinant collagen hydrogel wound dressing and its preparation method and application, so as to solve the problems of cumbersome preparation steps and easy cytotoxicity in the prior art

Method used

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  • Recombinant collagen hydrogel wound dressing and preparation method and application thereof
  • Recombinant collagen hydrogel wound dressing and preparation method and application thereof
  • Recombinant collagen hydrogel wound dressing and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 9.0 g of sodium chloride and dissolve it in 1000 mL of deionized water, stir until completely dissolved, and prepare a 0.9% sodium chloride solution. Weigh 5.0 g of sodium alginate, add 94 mL of the 0.9% sodium chloride solution prepared above to fully swell. After the sodium alginate is completely swollen, add 1.0 g of recombinant collagen and stir well until the recombinant collagen is completely dissolved and mixed evenly. The homogeneously mixed hydrogel is sterilized by high pressure steam to prepare a sterile recombined collagen hydrogel wound dressing.

Embodiment 2

[0031] Weigh 9.0 g of sodium chloride and dissolve it in 1000 mL of deionized water, stir until completely dissolved, and prepare a 0.9% sodium chloride solution. Weigh 4.0 g of sodium carboxymethylcellulose, add 95 mL of the 0.9% sodium chloride solution prepared above to fully swell. After the sodium carboxymethyl cellulose is completely swollen, add 1.0 g of recombinant collagen and stir well until the recombinant collagen is completely dissolved and mixed evenly. The homogeneously mixed hydrogel is sterilized by high pressure steam to prepare a sterile recombined collagen hydrogel wound dressing.

Embodiment 3

[0033] Weigh 9.0 g of sodium chloride and dissolve it in 1000 mL of deionized water, stir until completely dissolved, and prepare a 0.9% sodium chloride solution. Weigh 3.0 g of xanthan gum, add 96 mL of the 0.9% sodium chloride solution prepared above to fully swell. After the xanthan gum is completely swollen, add 1.0 g of recombinant collagen and stir well until the recombinant collagen is completely dissolved and mixed evenly. The homogeneously mixed hydrogel is sterilized by high pressure steam to prepare a sterile recombined collagen hydrogel wound dressing.

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Abstract

The invention relates to the technical field of wound dressing, in particular to recombinant collagen hydrogel wound dressing and a preparation method and application thereof. The hydrogel wound dressing provided by the invention is prepared by compounding recombinant collagen, sodium chloride, a thickening agent and deionized water and then performing sterilization. The medical hydrogel wound dressing belongs to external gel dressing, and has good moisturizing, hemostasis and adhesive property, and is capable of promoting wound healing and protecting cambium of a wound, and reducing scar formation, and suitable for treating ulceration, burn, postoperative wound, bruise and other wounds. The medical hydrogel wound dressing is simple to prepare, the production cost is low, and suitability for large-scale production is achieved.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a hydrogel wound dressing. Background technique [0002] Collagen is the main component of the extracellular matrix. It has a unique tissue structure and biological function. It plays an important role in maintaining the normal physiological functions and repairing of cells, tissues and organs. Its application in the field of biomedical materials has broad prospects . However, collagen currently used as biomedical materials is mostly extracted from animal tissues, which has the disadvantages of animal virus safety hazards (such as mad cow disease, foot-and-mouth disease, plague, etc.), rejection, and unstable quality. [0003] In order to make full use of the characteristics of collagen and seek collagen sources other than animals themselves, scientists have used genetic engineering techniques to recombine human genes into host cells, including: Escherichia coli (see Fan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0033A61L26/0066A61L26/008A61L2300/252A61L2300/412A61L2400/04C08L5/04C08L1/286C08L5/00
Inventor 樊璐露高佩朱世辉李海航
Owner 江苏创铭医疗器械有限公司
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