Procaterol hydrochloride tablets and preparation method thereof

A technology of procaterol hydrochloride and fillers, which is applied in pill delivery, respiratory diseases, drug combination, etc. It can solve the problems of unsuitability for industrial production, low content of finished products, and large loss, and achieve good disintegration effect and high yield of finished products. The effect of high rate and fast dissolution rate

Inactive Publication Date: 2018-07-20
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of the main component in the finished product is very small, and the loss by spraying is very large, resulting in low content of the finished product and low yield
At the same time, this process requires complex processes such as ball milling and spray granulation, which has large losses, low yields, high energy consumption, and is not suitable for industrial production.

Method used

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  • Procaterol hydrochloride tablets and preparation method thereof
  • Procaterol hydrochloride tablets and preparation method thereof
  • Procaterol hydrochloride tablets and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0018] The present invention also provides a kind of preparation method of Procaterol hydrochloride sheet, comprises the following steps;

[0019] S1, pretreatment;

[0020] Sieve the disintegrating agent and the second filler separately to ensure that each powder obtained has a suitable particle size, which facilitates good mixing of the subsequent powders, facilitates granulation and tablet compression, and prevents loose tablets. Ensure that the above-mentioned substances are easy to disintegrate and dissolve after taking, and then improve the absorption efficiency of Procaterol Hydrochloride in the human body.

[0021] Specifically, the above-mentioned substances are respectively passed through a 100-200 mesh sieve, and the selected sieve is a nylon sieve to prevent iron filings on the surface of the metal sieve, thereby affecting the efficacy and purity of the Procaterol Hydrochloride Tablets.

[0022] Procaterol hydrochloride is dissolved in 100-120 ml of aqueous soluti...

Embodiment 1

[0041] The present embodiment provides a kind of procaterol hydrochloride tablet (100,000 pieces), and it comprises multiple raw materials, and multiple raw materials comprises 0.0025kg procaterol hydrochloride, 0.17Kg disintegrant, 1.2 parts of the first filler and 4.2 kg accessories. Among them, the auxiliary materials include 3.6kg of second filler and 0.6kg of wetting agent. The disintegrant is croscarmellose sodium, the second filler is PH102 microcrystalline cellulose, the wetting agent is ethanol, and the first filler is α-starch.

[0042] The present invention also provides a kind of method for preparing Procaterol hydrochloride sheet, comprises the following steps:

[0043] S1, pretreatment;

[0044] Cross-linked sodium carboxymethyl cellulose and microcrystalline cellulose were respectively passed through a 100-mesh sieve.

[0045] Procaterol hydrochloride was dissolved in 100ml of aqueous solution, and then a wetting agent was added and stirred evenly to obtain a...

Embodiment 2

[0060] The ingredients of the Procaterol Hydrochloride Tablets provided in this example are basically the same as those of the Procaterol Hydrochloride Tablets provided in Example 1, except that the ratios used are changed. Specifically, a variety of raw and auxiliary materials include 0.003kg of Procaterol hydrochloride, 0.1kg of croscarmellose sodium, 1kg of α-starch and 3.5kg of auxiliary materials, and 3.5kg of auxiliary materials include 3kg of PH101 type microcrystalline cellulose and 0.5kg of isopropyl alcohol.

[0061] The preparation method of Procaterol Hydrochloride Tablets provided in this example is consistent with the steps of the preparation method of Procaterol Hydrochloride Tablets provided in the Example, the difference is that the operating conditions are changed. Specifically, during pretreatment, the sieve is 200 mesh, and the aqueous solution used is 120ml. In the initial granulation process, the second filler used was 75%, and the sieve was 80 mesh, and...

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Abstract

The invention relates to the field of pharmacy, in particular to procaterol hydrochloride tablets and a preparation method thereof. The procaterol hydrochloride tablets are prepared from a plurality of raw and auxiliary materials: 0.002 to 0.003 part of procaterol hydrochloride, 0.1 to 0.2 part of a disintegrating agent, 1 to 2 parts of a first filling agent and 3.5 to 5 parts of auxiliary materials. According to the preparation method of the procaterol hydrochloride tablets, various raw and auxiliary materials can be fully and uniformly mixed; the yield is high; the main components of the tablets are not wrapped by the auxiliary materials, so that the dissolving-out speed is high, and the stability is high. Meanwhile, the tablets are low in dose and simple in prescription, and only contain the several raw and auxiliary materials; the energy consumption in a preparation process is low.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a procaterol hydrochloride tablet and a preparation method thereof. Background technique [0002] Procaterol hydrochloride is also known as Meichuanqing, Puximin, iprocaterol, Procaterol, Procaterol hydrochloride, etc. The main ingredient is Procaterol hydrochloride. It is used to prevent and treat wheezing symptoms caused by bronchial asthma, asthmatic bronchitis and chronic obstructive pulmonary disease. And the commonly used dosage form of Procaterol Hydrochloride includes tablet and granule, because the prepared Procaterol Hydrochloride tablet specification is small, each material is not easy to mix evenly, and the medicine is difficult for stripping after making tablet, then causes Procaterol Hydrochloride tablet Reduced potency. The patent with application number CN201710409682.5 uses lactose as a filler, and the patient may have lactose intolerance, which in turn increases the si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4704A61K47/36A61K47/38A61P11/06A61P11/00
CPCA61K9/2054A61K9/2059A61K31/4704
Inventor 杨莉梅勇周年华谯志文罗磊朱锋陈小雪左娟王凤
Owner 重庆希尔安药业有限公司
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